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BİTKİSEL FLAVONOİD BİLEŞİKLERİNİN BİYOAKTİVİTELERİ VE MUHTEMEL ETKİ MEKANİZMALARI

BIOACTIVITIES OF PLANT FLAVONOIDS AND THE POSSIBLE ACTION MECHANISMS

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Abstract (2. Language): 
Flavonoids are isolated from plant extracts and present in diet of humans. They are a subgroup of the more extended family of polyphenols. Epidemiological studies have suggested that flavonoids decrease death from coronary heart disease and stroke incidence. Flavonoids are potent scavengers of reactive species (superoxide,peroxyl radical and peroxynitrite). Some of the activities attributed to flavonoids include antioxidant, antitrombotic, antihypertensive, antiallergic, antiinflammatory, antiapoptotic and anticancerogen. Flavonoids are vasodilatory through a variety of mechanisms and may exert it in endothelium-dependent or independent manners. There is evidence that administration of flavonoids may provide protection against myocardial ischemia- reperfusion. This review presents the possible mechanisms of cardioprotective effects of flavonoids.
Abstract (Original Language): 
Flavonoidler çoğu bitkilerde bulunan düşük moleküler ağırlıklı polifenolik bileşiklerdir. Özellikle bitkilerdeki yeşil, turuncu, kırmızı pigmentlerden sorumlu yapılar olarak tanımlanırlar. İn vivo, in vitro ve epidemiyolojik çalışmalarla tespit edilmiş birçok biyoaktiviteleri bildirilmektedir. Kardiyovasküler sistem üzerine olan aktiviteleri en çok üzerinde durulan etkileridir. Bunun yanında serbest radikal uzaklaştırıcı (antioksidan), anti-trombotik, antihipertansif, antiallerjik, antienflamatuar, antiapoptotik ve son zamanlarda da antikanserojen aktiviteleri üzerinde çalışmalar devam etmektedir. Ayrıca flavonoidler çeşitli mekanizmalarla vasodilatator etkilidirler ve bu aktiviteleri endotelyuma bağımlı veya endotelyumdan bağımsız bir tarzdadır. Özellikle iskemi - reperfüzyon hasarında farklı birçok mekanizma ile flavonoidlerin koruyucu aktiviteleri ileri sürülmektedir. Bu derlemede flavonoidlerin kardiyoprotektif aktivitelerindeki muhtemel etki mekanizmaları ele alınmıştır.
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