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NİFEDİPİN VE SİKLOSPORİN KULLANIMINA BAĞLI OLARAK OLUŞAN DİŞETİ HİPERPLAZİSİ

GINGIVAL HYPERPLASIA INDUCED BY NIFEDIPINE AND CYCLOSPORINS

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1993

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Gingival hyperplasia is a well-known side effect of the drug phenytoin. Recently, however, nifedipine and cyclosporine have been implicated in the causation of a phenytoin-like gingival enlargement. Nifedipine is an increasingly used medication for the treatment of vasospastic angina, chronic stable angina and ventricular arrhytmias. Cyclosporine is a potent im-munosuppresive compound that has been used in conjunction with kidney, liver, heart and other transplants. Studies have shown that hyperplasia can be prevented with careful oral hygiene before and during drug therapy. Because, several authors concluded that phenytoin, nifedipine and cyclosporine induced gingival overgrowth may be related to gingival irritants such as plaque and calculus. This article has summarized observations and results of controlled laboratory and clinical studies of drug-induced gingival hyperplasia associated with nifedipine and cyclosporine use.
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Abstract (Original Language): 
Dişeti Iıiperplazisi fenİtoinin iyi bilinen bir yan etkisidir. Son zamanlarda fenitoin benzeri dişeti büyümesine ni-fedipin ve sİklosporinin de neden olduğu gösterilmiştir. Nifedipin, vazospastik anjin, kronik stabil anjin ve ventriküler aritmi tedavisinde sıklıkla kullanılan bir ilaçtır. Siklosporin ise böbrek, karaciğer, kalp ve öteki organ transplantasyonlarında organ reddini önlemek amacıyla im-munsüpresif olarak kullanılır. Yapılan çalışmalar bu ilaçlarla tedaviden önce ve tedavi sırasında dikkatli ağız bakımı ile hiperplazinin önlenebileceğini göstermiştir. Çünkü raporlara göre ilaçlarla oluşan dişeti hiperplazi ile plak ve diş taşı gibi dişeti irritan-ları arasında yakın bir ilişki görülmektedir. Bu makalede nifedipin ve siklosporin kullanımına bağlı oluşan dişeti hiperplazilcri İle ilgili laboratuvar ve klinik çalışmaların sonuçları ve konuya ilişkin gözlemler özetlenmiştir.
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REFERENCES

References: 

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