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HİPERBARİK OKSİJENİN KEMOTERAPİ GÖRMÜŞ SIÇANLARDA KEMİK DEFEKTİ VE YARA İYİLEŞMESİNE OLAN ETKİLERİNİN DENEYSEL OLARAK ARAŞTIRILMASI

AN EXPERIMENTAL STUDY ON EFFECT OF HBO ON BONE DEFECT AND WOUND HEALING IN CHEMOTHERAPY APPLIED RATS

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1995

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The aim of this study is to investigate the effect of HBO on the problems in wound healing seen following chemotherapy in oral region. In our previous study, it was shown thai HBO didn 't have any effect on normal tissue healing except early healing period. During this study, 28 male rats were injected intraperitoneally 60 mg/kg 5-Fîuorouracil three times every five days. On the 13ih day, mandibular 1st and 2nd molar teeth were extracted under ether anaesthesia. The rats in the experimental group were exposed to hyperbaric oxygenation at 2.5 ATA twice a day. The control group didn't receive any treatment. Three rats from each group were sacrificed on 7th, 14th, 21th and 28th days and histo-paüıologic examination were performed. According to the results, there was not a difference in tooth extraction healing between HBO and control groups. This might be due to die chemoterapic drug and chemotherapy protocol we used.
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Abstract (Original Language): 
Bu çalışmanın amacı, hiperbarUt oksijenin kemotera-pinin oral yapılarda yol açabileceği yara iyileşmesinin gecikmesi üzerinde gösterdiği etkilerin araştırılmasıdır. Daha önceki çalışmamızda hiperbarik oksijenin erken dönem dışında normal doku iyileşmesine belirgin bir etkisinin olmadığını saptamıştık. Çalışmada 28 adet erkek sıçana beşer gün ara ile üç kez intraperitoneal 60 mg/kg 5-Fluorourasİl enjekte edildi. Onüçüncü günde eter anestezisi altında alt 1. ve 2. molar dişleri çekildi. Deney grubunu oluşturan sıçanlar günde ikİ kez 2.5 ATA'hk basmç alanda hiperbarik oksijene maruz bırakıldılar. Kontrol grubunu oluşturan sıçanlara ise herhangi bir tedavi uygulanmadan normal iyileşmeye bırakıldılar. Her gruptan üçer hayvan 7., 14., 21 ve 28. günde sakrifîye edilerek histopa-tolojik incelemeye alındı. Bu çalışma sonucuna göre, uyguladığımız kemotera-pik ajan ve kemoterapi protokolü ile tedavi görmüş sıçanların çekim yarası iyileşmesine etki açısından hiperbarik oksijen ve kontrol grupları arasında bir fark görülmemiştir.
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  • Turkish

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