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SİGARANIN MİNE MATRİKS PROTEİNLERİ VE BİYOAKTİF CAM ESASLI VEYA SIĞIR KAYNAKLI KEMİK GREFT MATERYALİ KOMBİNASYONLARI ÜZERİNE ETKİLERİ

EFFECT OF SMOKING ON ENAMEL MATRIX PROTEINS IN COMBINATION WITH BIOACTIVE GLASS OR BOVINE DERIVED XENOGRAFT

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 2011

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The aim of this study was to evaluate the effect of smoking following regenerative periodontal treatment in generalized aggressive periodontitis patients with, enamel matrix derivative (EMD) combined with a bovine derived xenograft (BDX)(EMD+BDX) or EMD combined with a bioactive glass (BG)(EMD+BG). Twenty patients 10 smokers, 10 non-smokers were included. Intrabony defects with probing depth (PD) of > 5 mm and intrabony component of > 3 mm were treated either with EMD+BDX or EMD+BG. Clinical and radiographical parameters were recorded prior to surgery and 8 months after treatment. At 8 months, in the EMD+BDX and EMD+BG groups, smokers showed 3.09+1.18 mm and 3.16+0.96 mm PD reduction, 1.93+0.64 mm and 1.86+0.72 mm attachment gain, 1.24+0.33 mm and 0.92+0.31 mm clinical bone gain, 0.58+0.31mm and 0.59+0.80 mm radiographic bone gain, respectively. On the other hand, non-smokers showed 3.55+1.07 mm and 3.43+1.30 mm probing depth reduction, 2.17+0.61 mm and 2.0+0.69 mm attachment gain, 1.29+0.31 mm and 1.20±0.25 mm clinical bone gain, 0.69±0.37 mm and 0.60±0.75 mm radiographic bone gain, respectively. Intergroup differences were found to be insignificant. Within its limits, it can be concluded that smoking does not affect the regenerative treatment outcomes in intrabony defects treated with EMD+BDX and EMD+BG:
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Abstract (Original Language): 
Bu çalışmada, sigaranın, mine matriks proteinleri (MMP) ve biyoaktif cam esaslı (BC) veya sığır kaynaklı kemik greft (SKKG) materyali ile kombine kullanımı üzerindeki etkisinin değerlendirilmesi amaçlandı. Çalışmaya 10 sigara içen 10 sigara içmeyen 20 generalize agresif periodontitis hastası dahil edildi. Her hastada MMP+BC ve MMP+SKKG kombinasyonları sondalama derinliği (SD) > 5 mm ve kemik içi defekt derinliği > 3 mm olan kemik içi defektlere uygulandı. Klinik ve radyografık değerlendirmeler operasyondan önce ve operasyon sonrası 8. ayda yapıldı. Defektin en derin noktasında, sigara içen bireylerde, MMP+BC ve MMP+SKKG gruplarında sırasıyla, 3.16+0.96 mm ve 3.09+1.18 mm SD azalması, 1.86 ±0.72 mm ve 1.93+0.64 mm ataşman kazancı, 0.92+0.31 mm ve 1.24+0.33 mm klinik kemik kazancı, 0.59+0.80 mm ve 0.58+0.31 mm radyografık kemik kazancı, sigara içmeyen bireylerde, MMP+BC ve MMP+SKKG gruplarında sırasıyla, 3.43+1.30 mm ve 3.55+1.07 mm SD azalması, 2.0+0.69 mm ve 2.17+0.61 mm ataşman kazancı, 1.20+0.25 mm ve 1.29+0.31 mm klinik kemik kazancı, 0.60+ 0.75 mm ve 0.69+0.37 mm radyografık kemik kazancı elde edildi. Her iki tedavi grubunda da sigara içen ve içmeyen bireyler arasında incelenen parametreler açısından istatistiksel olarak anlamlı bir fark bulunmadı (p>0.05). Bu çalışmanın sınırları dahilinde sigaranın her iki rejeneratif materyal kombinasyonları üzerinde anlamlı bir etkisinin olmadığı sonucuna varılabilir.
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