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Sülünlerde Antikoagülan Rodentisit Bromadiolone ile Oluşturulan Deneysel Akut İntoksikasyonun Morfolojik İncelenmesi

Morphological Investigations of Experimental Acute Intoxication with the Anticoagulant Rodenticide Bromadiolone in Pheasants

Journal Name:

  • İstanbul Üniversitesi Veteriner Fakültesi Dergisi

Publication Year:

  • 2012

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Morphological investigations were performed to observe the changes after experimental acute intoxication with the anticoagulant rodenticide bromadiolone in pheasants. The study was performed with 8 groups of pheasants treated with increasing doses of the tested preparation: 5 mg/kg (group I), 10 mg/kg (group II), 20 mg/kg (group III), 30 mg/kg (group IV), 40 mg/kg (group V), 50 mg/kg (group VI), 60 mg/kg (group VII) and 70 mg/kg (group VIII). All birds from groups I to V have survived the intoxication whereas those from groups VI, VII and VIII have died. During the intoxication, inappetence, accelerated and difficult breathing, adynamia, watery blood discharge from the beak were observed. All pheasants with fatal outcome and the survivors, which were euthanized after the experiment (day 20) were necropsied and gross changes in the liver, the lungs and kidneys were described. Liver alterations varied from strong hyperaemia and activation of the monocytic-macrophageal system to diffuse vacuolar or granular parenchymal dystrophy, as well as necrobiotic to necrotic changes, intra- and inter-lobular haemorrhages, perivascular mononuclear proliferations and bile duct hyperplasia. Lungs exhibited congestive hyperaemia, oedema in the interstitium and the mucous coats of bronchi and parabronchi, desquamation of epithelial cells in bronchioles and lung parenchymal haemorrhages. In the kidney parenchyma, congestive hyperaemia and haemorrhages were seen, varying within a bro ad range from karyolysis and karyopyknosis in epithelial tubular cells to cellular desquamation and disintegration and necrosis. All observed changes in parenchymal organs were dose-related, being more pronounced in pheasants treated with higher doses of the tested rodenticide.
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Abstract (Original Language): 
Sülünlerde antikoagülan rodentisit bromadiolone kullanılarak geliştirilen deneysel akut intoksikasyondan sonra değişimleri gözlemlemek amacıyla morfolojik incelemeler yapılmıştır. Çalışmada 8 grup sülün artan dozlarda incelemeye alındı: 5 mg/kg (Grup 1), 10 mg/kg (Grup 2), 20 mg/kg (Grup 3), 30 mg/kg (Grup 4), 40 mg/kg (Grup 5), 50 mg/kg (Grup 6), 60 mg/kg (Grup 7) ve 70 mg/kg (Grup 8). Birinci ve 5. gruplar arasındaki kuş gruplarının hepsi intoksikasyondan hayatta kalırken; 6., 7. ve 8. grupların öld üğü saptanmıştır. İntoksikasyon sırasında, iştahsızlık, hızlı solunum ve solunum güçlüğü, bitkinlik, gagadan sulu kan geldiği gözlenmiştir. Deney sonucunda (20 gün) ötenazi yapılarak nekropsisi yapılan hayatta kalan sülünlerin ve ölen sülünlerin nekropsilerinde dalak, akciğer ve böbreklerde değişiklikler saptandı. Dalakta şiddetli hiperemi ve monositik-makrofaj sisteminin aktivasyonu sonucu diffuz vakuoler ya da granüler parenkimal distrofi, intra ve inter lobuler hemorajiler, perivasküler mononükleer proliferasyonlar ve safra kanalı hiperplazisi görülmüştür. Akciğerlerde konjestif hiperemi, interstitiyum, bronş ve parabronşların mukoz membranlarında ödem, bronşiollerde bulunan epitel hücrelerde deskuamasyon ve parenkimal hemorajiler görülmüştür. Böbrek parenkiminde, konjestif hiperemi ve hemorajiler görülmüş, epitelyal tubuler hücrelerinde değişen derecelerde karyolizis ve karyopiknozis alanları, hücresel deskuamasyon ve parçalanma ve nekroz odakları görülmüştür. Parenkimal organlarda gözlenen tüm değişiklikler doza bağlı olarak değişmekle birlikte, rodentisitin yüksek dozda uygulandığı sülünlerde değişimler daha belirgin olarak seyretmiştir.
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  • 2
161-173
  • English

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