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Çocukluk çağı kronik Myeloid Lösemilerinin iki tipi, iki olgu sunumu

Two types Of chronic Myeloid Leukemia İn childhood, two cases report.

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Chronic myeloid leukemia accounts for 2-5% of cases of childhood leukemia. There are two types: adult type (A-CML) and juvenile type (J-CML). Juvenile type accounts for 18% of cases of the childhood myelodysplastic syndrome. Adult type is seen in the childhood period two foid of juvenile type. Leucocytosis, splenomegaly, lymphadenopathy, bone marrow elements in the periferic smear are the common findings. Skin rash, monocytosis, fetal hemoglobin above 10% and absence of Phiiadeiphia (Ph) chromosome are the typical findings of J-CML and increase in the number of the megakaryocytic and eosinofilic series in the bone marrow, leucocytosis above 100.000/mm 3 and existence of Ph chromosome are the typical findings of A-CML. Since the chronic leukemia cases are rarely seen in the childhood period, we aimed to present two cases having mentioned symptoms, one of which is a 3 years old boy diagnosed as J-CML, the other is 4 years old boy diagnosed as A-CML
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Abstract (Original Language): 
Kronik myelositer lösemi (KML) çocukluk çağı lösemilerinin %2-5'ini oluşturur. Adult tip ve juvenil tip şeklinde iki formu vardır. Juvenil tipi (J-KML) çocukluk çağı tüm myelodisplastik sendrom vakalarının %18'ini oluşturmaktadır. Adult tip ise (A-KML) çocukluk çağında juvenil tipten iki kat daha fazla görülür. Lökositoz, splenomegali, ienfadenopati, periferik yaymada kemik iliği elemanlarının görülmesi ortak bulgulardır. Ciltte döküntü, monositoz, fetal hemoglobinin %10'dan fazla oluşu ve Phiiadeiphia (Ph) kromozomunun olmayışı J-KML için tipik bulgular olup, kemik İliğinde megakaryosit ve eozinofilik serinin artmış olması, lökosit sayısının 100000/ mm 3'den fazla oluşu ve Ph kromozomu varlığı A-KML için karakteristik bulgulardır. Çocukluk çağında kronik lösemilerin nadir görülmesi dolayısıyla, bahsedilen bulgulara sahip, biri üç yaşında olup juvenil tip, diğeri dört yaşında olup adult tip KML tanısı alan iki vakayı literatür bilgilerini gözden geçirerek sunmayı düşündük.
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  • 1
63-66
  • Turkish

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