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Astım Patogenezi

Pathogenesis of asthma

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Asthma is one ofthe commonest diseases in children and adults in many countries. The prevaience of asthma has dramaticaily increased in recent years. The development of asthma depend on an interaction between genetic factors, environmental exposure to allergens, and nonspesific adjuvant factors such as tobacco smoke, air poilu-tion, and viral infections. These factors initiates a sehes of immunological changes, resulting in ainvay inftamma-fion. The airway inflammatory process is characterized by chronic eosinophilic and Th2 type lymphocytic infiltra-tion. Although the knowledge about asthma pathogenesis has increased, the prevaience of asthma has not decreased. Therefore, the asthma stili is a threat for the society's health at the beginning of the 21si century.
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Abstract (Original Language): 
Astım dünyanın pek çok ülkesinde gerek çocukların gerekse erişkinlerin en sık görülen hastalıklarından birisidir. Astımın; genetik yatkınlık, viral enfeksiyonlar, inhaler allerjenler, hava kirliliği ve sigara dumanı gibi birçok faktörün neden olduğu hava yolu inflamasyonu ile karakterize bir hastalık olduğu anlaşılmıştır. Bu infiamasyonun temelinde Th2 tip lenfositlerin ve eozinofillerin Önemli rol oynadığı gösterilmiştir. Ancak astımın patogenezi konusundaki bil¬gilerimizin artması, astım prevelansındaki artışı engelleyememiştir. Bu nedenle 21. yüzyılın başlarında bulun¬duğumuz şu yıllarda astım, önemli bir sağlık sorunu olma özelliğini hala korumaktadır.
FULL TEXT (PDF): 
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  • 4
267-273
  • Turkish

REFERENCES

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