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Yüksek doz florun sıçan dokularına etkisi

The effect of high dose florid on rat tissue

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
İn our study, We have aimed to search the findings seen on the tissue specimens taken from the liver, kidney, ovary, testis and pancreas of many rats that have been poisoned by long- term high doses of florid. Twenty rais which beiong to VVistar Albino species were being equally separated into two groups, one is as the experimental group, the other as the control group [10 (5 male + 5 female) * 10 (5 male + 5 female)]. For a 17 weeks time, dhnking water consisting of 1 ppm florid to control group and consisting of 150 ppm florid to experimental group has been given. Pieces taken from the tissue specimens of the liver, kidney, spleen, ovary, testis and pancreas were being examined under the light microscope. İn the experimental group, the foilowing findings were being obtained: İn peripherai lobule of the liver, focal sinusoidal diiatations, in the portal area, lymphocyte infiitration; in hepatocytes a liftle hydropic and vacuolar degeneration; in the kidney either in proximal or distal tubule, a little hydropic degeneration were being determined. There hasn't been seen any pathology in the spleen, ovary, testis and pancreas sections taken from the experimental group. As a result, it was determined that high doses of florid causes minimal structural changes phmahly in the liver tissue and then in the kidneys, besides it has no considerable effect on the testis, ovary, spleen and pancreas tissue.
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Abstract (Original Language): 
Çalışmamızda, yüksek dozda uzun süreli flor zehirlenmesi oluşturulan sıçanların karaciğer, böbrek, dalak, ovaryum, testis ve pankreas doku örneklerinde görülen etkileri araştırmayı amaçladık. VVistar Albino cinsi 20 adet sıçan eşit olarak deney ve kontrol grubu olarak iki gruba [10(5 erkek + 5 dişi) +10(5 erkek + 5 dişi)] ayrıldı. Kontrol grubunun içme suyunda flor oranı 1 ppm olacak şekilde, deney grubuna ise 150 ppm flor içirecek şekilde 17 hafta süreyle verildi. Karaciğer, böbrek, dalak, ovaryum, testis ve pankreas doku örneklerinden alınan parçalar ışık mikroskobunda değerlendirildi. Deney grubunda; karaciğerde lobul periferinde foka! sinuzoidal dilatasyonlar, por-tal alanda yer yer lenfosit infiltrasyonu, hepatositlerde az miktarda hidropik ve vakuoler dejenerasyon gözlendi. Böbrekte ise, gerek proksimal gerekse distal tubuluslarda hafif hidropik dejenerasyon tespit edildi. Deney grubun¬daki dalak, ovaryum, testis ve pankreas kesitlerinde ise herhangi bir patolojiye rastlanmadı. Yüksek doz verilen florun başta karaciğer olmak üzere daha sonra böbrek dokusu üzerinde minimal düzeyde yapısal değişikliklere yol açarken; testis, ovaryum, dalak ve pankreas dokusu üzerine ise önemli bir etkisinin olmadığı sonucuna varıldı.
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213-221
  • Turkish

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