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Çocuklarda desfluran ve isofluran anestezisinin derlenme özelliklerinin karşılaştırılması

Comprarison of recovery characteristics of desflurane and isoflurane in pediatric anesthesia

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
The study compares the recovery charecteristics of desflurane and isoflurane in children undergoing tonsiilectomy and/or adenoidectomy. Forty children 4-12 year of age were studied and thirty minutes prior to the induction of anesthesia, ali patients received 0.5 mg/kg midazolam orally. They were randomly assigned to receive 1-1.5 % isoflurane (group I) and 6-7 % desflurane (group II) for maintenance of anesthesia after patients given 2-2.5 mg/kg propofoi and 10 pg/kg alfentanyl for anesthesia induction. Before surgery, patients received 20 mg/kg paracetamol rectally for postoperative analgesia. Dexamethasone 150 pg/kg was given to reduce the incidence of postoperative nausea and vomiting. Administration of anesthetic agents was terminated at the end surgery. At the end of operation extubation and recovery time determined. Extubation time was defined as the time from discontinuation of anesthetics to extubation. Recovery time was measured from the time the anesthetics vvere discontinued until the patients achieved a score of 8 on the Aldrete score. Agitation was evaluated by using the three-point score. Extubation and recovery time were significantly faster in the desflurane group than isoflurane group (p<0.05). İncidence of agitation was similar for both groups. As a result, desflurane provides a faster recovery than isoflurane İn short-term surgery on children.
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Abstract (Original Language): 
Bu çalışmada tonsillektomi ve/veya adenoidektomi geçiren çocuklarda desfluran ve İsofluranın derlenme Özellik¬leri karşılaştırıldı. Yaşları 4-12 olan 40 çocuk çalışmaya alındı ve anestezi indüksiyonundan 30 dk. önce 0.5 mg/kg midazolam oral uygulandı. Anestezi indüksiyonu için 2;2.5 mg/kg propofoi ve 10 pg/kg alfentanil ven'ldikten sonra hastalar randomize olarak İki gruba ayrıldı ve anestezi idamesi için % 1-1.5 isofluran (grup I) ve % 6-7 desfluran (grup II) uygulandı. Cerrahi başlamadan önce, hastalara postoperatif analjezi için 20 mg/kg parasetamol rektal uygulandı. Postoperatif buiantt-kusma insidansını azaltmak İçin 150 pg/kg deksametason verildi. Anestezik ajanlar operasyon bitiminde kesildi. Ekstübasyon ve derlenme zamanı saptandı. Ekstübasyon zamanı anestezik gazların kesiminden, ekstübasyona kadar geçen süre; derlenme zamanı anestezik gazların kesiminden Aldret skoru 8 oluncaya kadar geçen süre olarak tanımlandı. Ajitasyon üç puanlı skoriama ile değerlendirildi. Ekstübasyon ve derlenme zamanı desfluran grubunda isofluran grubuna göre anlamlı olarak kısa bulundu. Ajitasyon insidansı iki grupta benzerdi. Sonuç olarak, çocuklarda kısa süreli cerrahi girişimlerde desfluran, isoflurana göre daha hızlı derlenme sağlamaktadır.
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  • Turkish

REFERENCES

References: 

1. Roige J, Canet J. Desflurane: a new İnhalation anes-thetic. Rev Esp Anesthesiol Reanim 1996;43:249-54.
2. Dupant J, Tavernier B, Ghosez Y, et al. Recovery after anaesthesia for pulmonary surgery: deflurane. sevofiu-rane and isoflurane. Br J Anaesih 1999;82:355-9.
3. Rampil I, Lockhart S, Zwass M, Eger El II, VVeiskopf RB, Damask MC. Clincal characteristics of desflurane in surgical patients: minimum alveolar concentration. Anesthesiology 1991 ;74:429-33.
4. Stevens W, Dolan W, Gibbons R, et al. Minimum alve-oler concentrations (MAC) of isofiurane with and with-out nitrous oxide in patients of various ages. Anesthesiology 1975;42:197-200.
5. Olson GL. Inhalational anesthesia at the extremes of age: peadiatric anaesthesia. Anaesthesia 1995;50:34-6.
6. Cohen İT, Hannallah RS, Hummer KA. The incidence of emergence agitation associated with desflurane anesthesia in children is reduced by fentanyi. Anesih Analg 2001;93:88-91.
7. Aidrete JA, Kroulik D. Postanestetic recovery score. Anesth Analg 1970;49:924-34.
8. Davis PJ, Cohen İT, McGowan FX Jr Latta K. Recovery characteristics of desflurane versus halothane for main-tenance of anesthesia in peadiatric ambulatory patients. Anesthesiology 1994;80:298-302.
9. Lerman J. Sevoflurane and desflurane in paediatric patients. Curr Opin Anaesth 1993;6:527-31.
10. Esener Z. Bebeklerde Anestezi. Anestezi Dergisi 1993;1:49-54.
11. Baykara N, Kılıçkan L Indelen S, Karabey F, Toker K. Günübirlik ameliyatlarda Propofoi ve Sevofluran anestezilerinin uyanma süresi ve postoperatif kusma insidansı yönünden karşılaştırılması. Türk Anest Rean Cem Mecmuası 1998;26:387-91.
12. VVelborn LG, Hannallah RS, Norden JM, Ruttimann UE, Callan CM. Comparison of emergence and recovery characteristics of sevoflurane, desflurane, and halothane in pediatric ambulatory patients. Anesth Analg 1996;83:917-20.
13. Tsai SK, Lee C, Kwan WF, Chen BJ. Recovery of cog-nitive functions after anaesthesia with desflurane or isoflurane and nitrous oxide. Br J Anaesth 1992:69:255-8.
14. Fletcher JE, Sebel PS, Murphy MR, Smith CA, Mick SA, Flister MP. Psychomotor performance after desflu¬rane anesthesia: A comparison with isoflurane. Anesth Analg 1991;73:260-5.
15. VViihelm W, Berner K, Grundmann U, Palz M, Larsen R. Desflurane or isoflurne for pediatric ENT anaesthesia. A comparison of intubating conditions and recovery profile Anaesthesist 1998;47:975-8.

16. Grundmann U, Uth M. Eichner A, Wi!he!m W; Larsen R. Total intravenous anaesthesia with propofoi and remifentanil in pediatric patients: a comparison with a desflurane-nitrous oxide inhalation anaesthesia. Açta Anaesthesiol Scand 1998;42:845-50.
17. Cohen İT, Finkel JC, Hannallah RS, Hummer KA, Patel KM, The effect of fentanyi on the emergence charac¬teristics after desflurane or sevoflurane anesthesia in children. Anesth Analg 2002;94:1178-81.
18. VVells LT, Rasch DK. Emergence "deiihum" after sevoflurane anesthesia: a paranoid delusion? Anesth Analg 1999;88:1308-10.
19. Uozono S, Goto T, Temi K, et al. Emergence agitation after sevoflurane versus propofoi in pediatric patients. Anesth Analg 2000;91:563-6.
20. Cravero JP, Surgenor SD, Whalen K. Emergence agi¬tation in pediatric patients after sevoflurane anesthesia and no surgery: a comparison wtth halothane (abstract) Anesthesiology 2000;91 :A1247.
21. Cohen İT, Hannallah RS, Hummer KA. The insidence of emergence agitation associated with desflurane anesthesia in children is reduced by fentanyi. Anesth Analg 2002;93:88-91.
22. Baxendale BR, Vater M, Lavery KM. Dexamethasone reduces pain and swelling foilowing extraction of third moierteeth. Anaesthesia 1993:48:961-4.
23. Liu K, HSU CC, China YY. The effective dose of dek-samethaone for antiemesis after majör gynecological surgery. Anesth Analg 1999;83:772:5.
24. Lee Y, ün PC, Lai HY, Huang SJ, Un YS, Cheng CR. Prevention of PONV with dexamethasone in female patients undergoing desfiurane anesthesia for thy-roidectomy. Açta Anaesthesiol Sin 2001:39:151 ;6.
25. Kuhn I, Scheifler G, VVissing H. İncidence of nausea and vomiting in children after strabismus surgery fol-lowing desflurane anaesthesia. Paediatr Anaesth 1999;9:521-6.
26. Hobbhahn J, Funk W. Sevoflurane in pediatric anes¬thesia. Anaesthesist 1996;45(Suppf):22-7.
27. Lodes U. Total intravenous anesthesia (TlVl) and bal-anced anesthesia with short acting anesthetics for ENT surgery in children. Anesthesiol Reanim 1999;24(1):13-8.
28. Pendit UA, Malviya S, Lewis IH. Vomiting after outpa-tient tonsillektomy and adenoidektomy in children: the role of nitrous oxide. Anesth Analg 1995;80:230-8.
29. Ved SA, VValden TL, Mantana J, et al. Vomiting and recovery after outpatient tonsillectomy and adenoidek-tomy in children. Comparison of four anesthetic tech-nİques using nitrous oxide with halothane or propofoi. Anesthesiology 1996;85:4-10.

30. Haynes R. Adrenocorticotropic hormone: adrenocorti-cal steroids and their syntethic analogs-inhibitors of synthesis and actions of adrenocortical hormones. İn: Goodmann Gilman A, Gilman LS. Rall TW, Murat F, editors. The pharmacological basis of therapetics 8th ed. New York: Pergamon Press, 1990:1447-8.
31. Siplinter W, Roberts J. Dexamethasone decreases vomiting by children after tonsülectomy. Anesth Analg 1996;83:916.

32. April MM, Callan ND, Nowak DM, Hausdarff MA. The of intravenous dexamethasone in pediatric adenoton-sillektomy. Arch Otolaryngol Head Neck Surg 1996;122:117;20, Siplinter WM. Roberts DJ. Dexamethasone decreases vomiting by children after tonsillectomy. Anesth Analg 1996:83:913-6.
33. Aouad MT: Siddik SS, Rizk LB, Zaytoun GM, Baraka AS. The effect of dexamethasone on postoperative vomiting after tonsillektomy. Anesth Analg 2001;92:636;40.
34. Uyar M. Pediatrik hastalarda ağrı tedavi yöntemleri. Galenos 1997:1:38-42.

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