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PERİMENOPOZAL SICAK BASMASINDA HORMONAL VE HORMONAL OLMAYAN FARMAKOLOJİK TEDAVİ YAKLAŞIMLARI

HORMONAL AND NON HORMONAL PHARMACOLOGICAL THREATMENT APPROACHES ABOUT PERIMENOPAUSAL HOT FLASHES

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Abstract (2. Language): 
This review sought to determine the hot flashes and treatment approach of perimenopause. Hot flashes are one of the most important signs of perimenopause. Hot flashes are recurrent, transient episodes of flushing, perspiration, and a sensation ranging from warmth to intense heat on the upper body and face, sometimes followed by chills. The exact cause of hot flashes has not been determined, although it seems that the changing endogenous estrogen concentrations associated with menopause may play a role. Although the spesific therapies do not “cure” hot flashes, they can provide significant relief. Many women experience hot flashes severe enough to seek treatment. Many women suffer persistent hot flashes that respond only to prescription medications hormones. The main focus of this review is on treatment prescription medications estrogen, estrogen/progestogen, only progestogen, medroxyprogesterone acetat, oral contraceptives, androgen-estrogen and nonhormonal options. Effective and safe treatment approach of perimenopause must be considered for hot flashes
Abstract (Original Language): 
Bu makalede perimenopozal dönemdeki sıcak basması ve tedavi yaklaşımları derlenmiştir. Perimenopozal dönemin en önemli özelliklerinden biri sıcak basmasıdır. Sıcak basması tekrarlayan, özellikle yüzde kızarmaya neden olan, terleme oluşturan, vücudun üst bölümlerinde ve yüzde yoğun ısı hissi yaratan ve ardından üşüme ile sonlanan bir durumdur. Sıcak basmasının nedeni tam olarak belirlenememekle birlikte; endojen östrojen hormonunun konsantrasyonunda değişiminin rol oynayabileceği düşünülmektedir. Sıcak basmasının spesifik bir tedavisi yoktur ve tedavi sadece bir ferahlama sağlamaktadır. Kadınların çoğu inatçı sıcak basmasından kurtulmak için medikal tedaviye gereksinim duymaktadır. Hormonlar bu yakınmaları azaltmak amacıyla sıklıkla kullanılmaktadır. Bu makalede hekim reçetesi ile kullanılan hormonal içerikli Östrojen/ Östrojen-Progesteron/ Progesteron, Medroxyprogesterone Asetat, Oral kontraseptif, Androjen- Östrojen tedavisine ayrıntılı bir şekilde yer verilmiştir. Ayrıca sıcak basmasının giderilmesinde etkili ve güvenli olduğu saptanan ve hormonal içerikli olmayan birtakım preparatlara da tartışılmıştır. Perimenopozal dönemdeki sıcak basması için etkili ve güvenli tedavi yaklaşımları benimsenmelidir.
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