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Saç ve Plazma Selenyum Seviyelerinin Angiografik Ciddi Koroner Arter Hastaliği ile İlişkisi

The Relation Between Hair and Plasma Selenium Levels and Angiographically Severe Coronary Artery Disease

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

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Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Trace element selenium is an important part of the oxidative system. It was shown cardiovascular disease in selenium metabolism disorders. However there is no clear data about selenium level in patients with coronary artery disease (CAD). In this study, we investigated the hair and plasma selenium levels in patients who have severe angiographic coronary artery disease. Total 52 patients were included the study. Thirty eight patients who have severe coronary stenosis (≥50%) were included to CAD group. Control group was consisted 18 patients with normal coronary artery. Hair and plasma specimen was taken from all patients to measure selenium levels (mg/dl). Hair selenium was similar in two groups (Control group: 0.6±0.8 vs. CAD group: 0.4±1.1, p=0.2). Plasma selenium levels was higher in CAD group (Control group: 71±8, vs. CAD group: 80±6, p<0.001). Sensitivity and spesivity levels for severe CAD were 88.24 (%95CI:72.5-96.6) and 72.22 (%95CI: 46.5-90.2). There was significant correlation between hair and plasma selenium levels. Although different results in literature, we found close relation between CAD and plasma selenium levels
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Abstract (Original Language): 
Selenyum oksidatif sistemin önemli bir parçası olan eser elementtir. Selenyum metabolizmasında bozuklarda kardiyovasküler hastalıkların gelişebileceği gösterilmiştir. Fakat koroner arter hastalığı (KAH) olan hastalarda selenyum düzeyleri hakkın yeterli veri yoktur. Bu çalışmada anjiyografik olarak ciddi KAH tespit edilen hastalardaki serum ve saç teli selenyum düzeylerini araştırdık. Çalışmaya 52 hasta dahil edildi. Koroner anjiyografide ciddi stenoz (≥ %50) tespit edilen 34 hasta KAH grubunda dahil edildi. Koroner arterleri normal olan 18 hasta kontrol grubuna alındı. Tüm hastalardan saç teli ve plazma örnekleri alınarak selenyum düzeyleri ölçüldü. Saç teli selenyum seviyesi kontrol grubunda daha fazla olmasına rağmen istatistiksel olarak anlamlı fark bulunamadı (Kontrol grubu: 0.6±0.8, KAH grubu: 0.4±1.1, p=0.2). Plazma selenyum seviyesi KAH grubunda anlamlı olarak fazla bulundu. (Kontrol grubu: 71±8, KAH grubu: 80±6, p<0.001). Plazma selenyum seviyesinin >71 olmasının ciddi KAH öngörmesindeki duyarlılığı; 88.24 (%95 CI:72.5 - 96.6) özgüllüğü: 72.22 (%95 CI: 46.5 - 90.2) olarak ölçüldü. Saç teli selenyum düzleri ile plazma düzeyleri arasında anlamlı korelasyon bulundu. Literatürdeki farklı sonuçlar elde edilmesine rağmen çalışmamızda plazma selenyum seviyeleri ciddi KAH varlığı ile yakın ilişkili bulundu.
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  • 2
101-104
  • Turkish

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