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Yenidoğanlarda Direkt Coombs Test Pozitifliğinin Değerlendirilmesi

Evaluation with Positive Direct Coomb’s Test in Newborn

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
In recent years, increase in the frequency of positive direct Coomb’s (DC) test in newborns without blood incompatibilitiy is remarkable. The objective of the present study is to determine the associated factors that causing this increase. Ninety-seven patients with positive DC test from 2362 newborns who were hospitalized in Neonatology Unit of Eskisehir Osmangazi University Faculty of Medicine between June 2004-November 2006 have reviewed retrospectively. The prevalance of positive DC test was 4.1%. Twenty-six patients were premature. Hemolysis was determined in 41 patients. In 22 patients DC test was negative initially, but became positive in time. The DC test were became positive during the time, in 34.6% of premature and 14% of term newborns respectively. In 35 patients without blood incompatibility; intrauterine and postpartum systemic inflammatory response syndrome (SIRS) and/or infection, various antenatal risks, intravenous immunoglobulin (IVIG) therapy and antibiotic use were determined. In the newborns with positive DC test, the most common etiologic factors after blood group incompatibility are SIRS and/or infection, transfusion of blood and blood products, IVIG therapy and more rarely the resulting antibodies from various reasons.
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Abstract (Original Language): 
Son yıllarda kan grubu uyuşmazlığı olmayan yenidoğanlarda pozitif direkt Coombs (DC) test sıklığındaki artış dikkati çekmektedir. Bu artışa neden olan faktörleri değerlendirmek amacıyla bu çalışma yapılmıştır. Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Yenidoğan ünitesinde Haziran 2004-Kasım 2006 yılları arasında takip edilen 2362 bebekten DC test pozitifliği saptanan 97 vakanın dosyası retrospektif olarak incelendi. DC test pozitiflik prevalansı %4.1 olarak bulundu. Olguların 26’sı prematüre idi. 41 hastada hemoliz vardı. 22 hastada başlangıçta negatif olan DC testi sonradan pozitifleşti. Prematürelerin %34.6’sında, matür bebeklerin ise %14’ünde DC pozitifliği sonradan saptandı. Kan grup uyuşmazlığı olmayan 35 hastada, intrauterin ve postpartum sistemik inflamatuar yanıt sendromu (SIRS) ve/veya enfeksiyon, çeşitli antenatal riskler, intravenöz immünglobulin (IVIG) tedavisi ve antibiyotik kullanımı tespit edildi. Yenidoğanlarda DC test pozitifliğine, kan grubu uyuşmazlığından sonra en sık SIRS ve/ veya enfeksiyon, kan ve kan ürünlerinin transfüzyonu, intravenöz IVIG tedavisi, daha nadir olarak ta çeşitli nedenlerle ortaya çıkan antikorlar neden oluyor gibi gözükmektedir.
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  • 2
73-76
  • Turkish

REFERENCES

References: 

1. Strobel E, Wullenweber J, Peters J. Detection
and side effects of isoantibodies in intravenously
administered immunoglobulin preparations.
Infusionsther Transfusionsmed. 1995; 22: 31-35.
2. Packman CH. Hemolytic anemia due to warm
autoantibodies. Blood Rev. 2008; 22: 17-31.
3. Ozdemir OM, Ergin H, Ince T. A newborn with positive
antiglobulin test whose mother took methyldopa in
pregnancy. Turk J Pediatr. 2008; 50: 592-94.
4. American Academy of Pediatrics Subcommittee
on Hyperbilirubinemia. Management of
hyperbilirubinemia in the newborn infant 35 or more
weeks of gestation. Pediatrics. 2004; 114: 297-316.
5. American College of Chest Physicians/Society of
Critical Care Medicine Consensus Conference:
definitions for sepsis and organ failure and guidelines
for the use of innovative therapies in sepsis. Crit
Care Med. 1992; 20: 864-74.
6. Dinesh D. Review of positive direct antiglobulin
tests found on cord blood sampling. J Paediatr Child
Health. 2005; 41: 504-07.
7. Cianciarullo MA, Ceccon ME, Vaz FA. Prevalence of
immunohematologic tests at birth and the incidence
of hemolytic disease in the newborn. Rev Assoc Med
Bras. 2003; 49: 45-53.
8. Herschel M, Karrison T, Wen M, Caldarelli L, Baron
B. Evaluation of the direct antiglobulin (Coombs’)
test for identifying newborns at risk for hemolysis
as determined by end-tidal carbon monoxide
concentration (ETCOc); and comparison of the
Coombs’ test with ETCOc for detecting significant
jaundice. J Perinatol. 2002; 22: 341-47.
9. Baptista-González H, Hernández-Martínez JA,
Galindo-Delgado P, Santamaría-Hernández C,
Rosenfeld-Mann F. Usefulness of direct antiglobulin
test in neonatal screening. Bol Med Hosp Infant Mex.
2009; 66: 500-07.
10. Kiruba R, Ong R, Han P. Direct enzyme linked
antiglobulin tests (ELAT) for detecting in-vivo
sensitized erythrocytes: evaluation of screening for
ABO incompatibility of newborn. Pathology. 1988; 20:
147-51.
11. Arndt PA, Garratty G. The changing spectrum of druginduced immune hemolytic anemia. Semin Hematol.
2005; 42: 137-44.
12. Johnson ST, Fueger JT, Gottschall JL. One center ’s
experience: the serology and drugs associated
with drug-induced immune hemolytic anemia--a new
paradigm. Transfusion. 2007; 47: 697-702.
13. Bilgen H, Ozek E, Unver T, Biyikli N, Alpay H, Cebeci
D. Urinary Tract Infection and hyperbilirubinemia.
Turk J Pediatr. 2006; 48: 51-55.
14. Xinias I, Demertzidou V, Mavroudi A, Kollios K,
Kardaras P, Papachristou F, et al. Bilirubin levels
predict renal cortical changes in jaundiced neonates
with urinary tract infection. World J Pediatr 2009; 5:
42-45.
15. Vucinovic M, Jadric H, Karelovic D, Roje D, HasplHundrić Z, Hrgović Z, et al. Haemolytic disease of the
newborn-from a mother with anti-Kell, anti-E and antiVel anti-erythrocyte alloantibodies. Z Geburtshilfe
Neonatol. 2004; 208: 197-202.

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