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Otistik Bozukluğu Olan Çocuk ve Ergenlerde Kolesterol Düzeyleri

Cholesterol Levels in Children and Adolescents with Autistic Disorder

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

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Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Autism, a neurodevelopmental disorder, Is defined by core abnormalities In reciprocal social Interaction and communication, and by the presence of restrictive or stereotyped interests and behaviors. Its etiology is almost unclear however a number of factors is being investigated including genetic, infectious, metabolic and environmental causes. Recent findings suggest the role of abnormal lipid metabolism in autism. The aim of this study was to investigate the incidence of cholesterol deficiency in a group of subjects with autistic dis-order (AD). Study group included 88 children and adolescents with autistic disorder according to DSM-IV criteria. Children with any diagnosed genetic, metabolic, or neurological disorders were excluded from the study. The mean cholesterol level was 150.5 ± 28.7 (81.0 - 230.0) mg / dl. Sixteen subjects (18.2 %) had a cholesterol level lower than 100 mg/dl, which is below the 5th centile. Our findings confirmed the high prevalence of abnormally low cholesterol levels in autistic disorder and support clinical significance regarding the possible role of cholesterol deficit in the etiology. Further studies are needed to investigate the relation between cholesterol metabolism and autism.
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Abstract (Original Language): 
Otizm sosyal İlişki ve İletişim alanlarında belirgin güçlükler, ylneleylcl-sınırlı-olağan dışı davranış ve ilgilerin olduğu nörogelişimsel bir bozukluktur. Otizmin nedeni halen net olarak bilinmemektedir fakat genetik, immünolojik, metabolik ve çevresel faktörlerin etkileşimiyle oluşan multifaktoriyel bir bozukluk olduğu düşünülmektedir. Otizmin etyolojisinde lipid metabolizmasında bozulmanın bulunduğuna dair kanıtlar giderek artmaktadır. Bu çalışmada otistik bozukluğu olan çocuk ve ergenlerin kolesterol düzeylerinin incelenmesi amaçlanmıştır. Çalışmaya DSM - IV ölçütlerine göre otistik bozukluk tanısı alan 88 çocuk ve ergen alınmıştır. Bilinen her hangi bir genetik, metabolik ve/veya nörolojik hastalığı olan olgular çalışma dışı bırakılmıştır. Ortalama kolesterol düzeyi 150.5 ± 28.7 (81.0 - 230.0) mg / dl olarak bulunmuştur. On altı olgunun (% 18.2) kolesterol düzeyinin iki yaşından büyük çocuklar için 5. persantil değeri olan 100 mg/dl'den düşük olduğu görülmüştür. Bu bulgular kolesterol metabolizmasında bozulmanın otistik bozukluk etyolojisinde rol alabileceğini desteklemektedir. Otizm ile kolesterol metabolizması arasında ilişkiyi inceleyen daha ileri çalışmalara gereksinin bulunmaktadır.
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  • 4
226-228
  • Turkish

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