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BİYOLOJİK AKTİVİTEYE SAHİP OLAN BAZI KARBOHİDRAT ORTO ESTER TÜREVLERİ

SOME CARBOHYDRATE ORTHOESTER DERIVATIVES WHICH HAVE BIOLOGICAL ACTIVITY

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Abstract (2. Language): 
In this study, structures of orto ester have been investigated. Sugar molecules having different orto ester functional groups on, facilitate the synthesis of targeted products in carbohydrate chemistry. Furthermore, orto ester functional groups can be also placed on sugar molecules including cyclic acetal and ketal groups. OAlkylidene and O-Alkylidine derivatives in cyclic acetal structure have protective properties. These cyclic structures on sugar molecules are very important compounds while they are used as starting substances to syntheses new compounds. α-Chloralose, [(R)-1,2-O-trichloroethylidene-α-D-glukofuranose] in cyclic acetal structure is a hypnotic compounds which is used in seed coating process in agricultural activities and as an anaesthetic substance in veterinary science. Therefore, cyclic acetal and ketal groups obtained from the reaction between polyhydroxyl compounds and aldehydes or ketones are in addition very important compounds since they have interesting biological activities.
Abstract (Original Language): 
Bu çalışmada, genel anlamda orto ester yapıları incelenmiştir. Değişik orto ester yapılarının şeker molekülleri üzerinde bulunması karbohidrat kimyasında sentezlenmesi hedeflenen ürünü elde etmek için kolaylık sağlamaktadır. Ayrıca orto ester grupları halkalı asetal veya ketal grubu taşıyan şeker molekülleri üzerinde de bulunabilmektedir. O-Alkiliden ve O-Alkilidin türevleri halkalı asetal yapısında olan koruyucu grup özelliğine sahip bileşiklerdir. Şeker molekülünde bulunan bu halkalı yapılar yeni bileşiklerin sentezlenmelerinde başlangıç maddeleri olarak kullanılabilmeleri nedeniyle karbohidrat kimyasında oldukça önemlidirler. Halkalı asetal yapısında bulunan α-kloraloz [ (R)-1,2-O-trikloroetiliden-α-D-glukofuranoz ] hipnotik bir bileşik olup, ziraat çalışmalarında tohum yüzey kaplamasında ve anestezik madde olarak veterinerlikte kullanım alanı bulmaktadır. Bu nedenle polihidroksi bileşikleri ile aldehit veya ketonların reaksiyonlarından oluşan halkalı asetaller ve ketaller ilginç biyolojik aktiviteye sahip olmalarından dolayı ayrıca önem taşırlar.
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