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Aterosklerozis prevalansı ile Hepatit B Virüs seropozitifliği arasındaki C-Reaktif Protein bağlantılı ilişki

Relatıonshıp between Hepatitis B Virus seropositivity and atherosclerosıs through C-Reactıve Protein

Journal Name:

  • Smyrna Tıp Dergisi

Publication Year:

  • 2012

Key Words:

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Abstract (2. Language): 
Objective: To determine the relation between coronary artery disease and immunoglobulin G type anti-HBs antibodies in detecting chronic inflammation through C-reactive protein. Material and Method: This study was performed between June 2001 and May 2004. A total of 320 cases with chest pain, suspected coronary artery disease existed during non-invasive tests and the patients, coronary angiography were applied; were included in the study. Results: The ratio of the patients who were seropositive for anti-HBs was 43% (n:138), 57% of them (n:182) were found to be negative. 59.4% of patients (n:190) had angiographic evidence of coronary artery disease during the coronary angiography assessment. 73% of these 190 patients (n:138) who were angiographically diagnosed as coronary artery disease, CRP>0,5 mg/dl; whereas 60% of the 130 patients (n:78) who were not diagnosed as coronary artery disease, CRP>0.5 mg/dl (p:0.018). 60% of the anti-HBs seropositive 138 patients (n:83), and %60 of the anti-HBs seronegative 182 patients (n:109) were angiographically diagnosed as coronary artery disease. Conclusion: As the amount of antibody synthesis during chronic hepatitis B infection is quite high, its contribution to the formation of atherosclerotic plaque is meaningful. Connection between hepatitis A seropositivity and coronary artery disease can not seen between hepatitis B seropositivity and coronary artery disease (such as found in this study results). This is because of the prevalance of hepatitis A in the society is nearly two times more than the prevalance of hepatitis B.
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Abstract (Original Language): 
Amaç: Koroner arter hastalığı ile immunglobulin G tipi anti-HBs antikorlar arasındaki ilişkiyi kronik inflamasyonun saptanması açısından C-reaktif protein aracılığı ile saptamak. Gereç ve Yöntem: Çalışma, 2001 Haziran-2004 Mayıs tarihleri arasında yapılmış olup; gögüs ağrısı olan veya non-invaziv testlerde koroner arter hastalığı şüphesi bulunan, koroner anjiyografi yapılmış, toplam 320 olgu çalışmaya dahil edilmiştir. Bulgular: Hastaların %43’ünde (n:138) anti-HBs seropozitifliği mevcut iken, %57’sinde (n:182) negatif olarak bulunmuştur. Koroner anjiyografi değerlendirmesinde, %59,4’ünde (n:190) koroner arter hastalığının anjiyografik kanıtları mevcuttur. Anjiyografik koroner arter hastalığı tanılı 190 hastanın %73’ünde (n:139) CRP>0.5 mg/dl saptanırken, tanı almayan 130 hastanın %60’ında (n:80) CRP>0,5 mg/dl saptanmıştır (p:0.018). Anti-HBs seropozitifliği saptanan 138 hastanın %60’ında (n:83), 182 anti-HBs seronegatif hastanın da %60’ında (n:109) anjiyografik koroner arter hastalığı tanısı konulmuştur. Sonuç: Kronik hepatit B enfeksiyonu esnasındaki antikor sentezi daha yüksek miktarda olduğundan aterosklerotik plak oluşumuna katkısı daha anlamlı olacaktır. Hepatit A seropozitifliği ile koroner arter hastalığı arasındaki bağlantının, hepatit B ile koroner arter hastalığı arasında saptanamamasının (çalışmamızda saptanan sonuç gibi) sebebi, toplumda hepatit A prevalansının hepatit B prevalansına oranla yaklaşık iki kat daha fazla olmasına bağlanmaktadır.
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  • Turkish

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