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Diyabetik ketoasidozlu olgularda hematolojik bulgular

Hematological Findings in Patients with diabetic ketoacidosis

Journal Name:

  • Smyrna Tıp Dergisi

Publication Year:

  • 2012

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Abstract (2. Language): 
Objective: Diabetic ketoacidosis (DKA) is a serious condition with the highest rates of morbidity and mortality in children with type 1 diabetes mellitus (T1DM). About 25% of children with newly diagnosed T1DM hospitalized with DKA. In this study, it is aimed to evaluate hematologic findings of children admitted with DKA. Material and Method: Records of 490 children admitted to Uludag University Faculty of Medicine, Department of Child Health with T1DM between January 2003 and October 2008 were retrospectively reviewed and clinical and hematologic data of 163 children with the diagnosis of DKA was investigated. Patients were divided into four subgroups according to their ages (0-4.99 years, 5-9.99 years, 10-14.99 years, 15-18 years). The severity of DKA is determined primarily by the pH level (mild; pH 7.2-7.3, moderate pH 7.1-7.2, severe pH<7.1). Leukocyte and thrombocyte counts and hemoglobin (Hb) levels were measured. Results: Of 490 children with T1DM, 163 (33.2%) had the diagnosis of DKA and total number of DKA episodes was 190. The mean age was 11.02±4.57 years. The mean leukocyte count was 15,663±9,787 cells/mm3 (3,340–48,700), Hb level was 13.35±1.74 g/dl (8.9–17.5), and thrombocyte count was 373,312±139,928 cells/mm3 (88,000–970,000). The total leukocyte and thrombocyte counts were increased significantly with decreasing pH. Conclusion: We believed that increased thrombocyte and leukocyte counts may result from hemoconcentration.
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Abstract (Original Language): 
Amaç: Diyabetik ketoasidoz (DKA) tip 1 diabetes mellituslu (T1DM) çocuklarda mortalite ve morbiditeye neden olan ciddi bir durumdur. Yeni T1DM tanılı hastaların yaklaşık %25’i DKA ile hastaneye başvururlar. DKA hematolojik parametreleri etkileyebilir. Bu çalışmada DKA ile başvuran hastalardaki hematolojik parametre düzeyleri incelenmiştir. Gereç ve Yöntem: Ocak 2003 ile Ekim 2008 tarihleri arasında Uludağ Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı’na yatan 490 T1DM’li olgudan DKA tanılı 163 hastanın 190 atağı incelendi. Olgular 0-4,99 yaş, 5-9,99 yaş, 10-14,99 yaş, 15-18 yaş olmak üzere 4 gruba ayrıldı. Kan gazı pH düzeylerine göre DKA derecesi (pH 7,3-7,2 arası hafif, pH 7,2-7,1 arası orta, pH <7,1 ise ağır) belirlendi. Hematolojik parametrelerden hemoglobin (Hb), lökosit ve trombosit sayılarına bakıldı. Bulgular: T1DM ile kliniğimize yatırılan olguların %33,2’si DKA ile başvurdu. Olguların yaş ortalaması 11,02±4,57 yıl idi. Ortalama lökosit sayısı 15.663±9.787 hücre/mm3 (3.340–48.700), Hb miktarı 13,35±1,74 g/dl (8,9–17,5), trombosit sayısı 373.312±139.928 hücre/mm3 (88.000–970.000) olarak saptandı. pH azaldıkça lökosit ve trombosit sayılarında istatistiksel olarak anlamlı derecede artış olduğu saptandı. Hb düzeyleriyle DKA derecesi arasında ilişki yoktu. Sonuç: Lökosit ve trombosit değerlerindeki yüksekliğin hemokonsantrasyona bağlı olduğu düşünülmektedir.
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  • 2
5-9
  • Turkish

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İletişim:
Uzm.Dr. Erdal Eren
Harran Üniversitesi Tıp Fakültesi Hastanesi
Çocuk Sağlığı ve Hastalıkları Anabilim Dalı
Yenişehir Kampüsü – Şanlıurfa
Tel: +90.505.7686947
e-mail: erderen@yahoo.com

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