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Treadmill stres test laboratuarında değerlendirilen hastalarda efor sonuçlarının test öncesi ve sonrası alınan hsCRP ve NT-proBNP düzeylerine göre değerlendirilmesi

Evaluation of treadmill stress test results of patients with their pre and post test hsCRP and NT-proBNP levels

Journal Name:

  • Smyrna Tıp Dergisi

Publication Year:

  • 2012

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Abstract (2. Language): 
Objective: Cardiovascular diseases are globally the most important cause of mortality and morbidity. It is clinically very important to have markers to identify, to treat this population and foreseeing the prognosis. It is curently known that hsCRP and NT-proBNP provide very important data for patients with coronary heart disease (CHD). Aim of the study is to evaluate the clinical benefits of hsCRP and NT-proBNP on detecting cardiovasculer events in patients with suspected CHD. Material and Method: Our study was performed on 81 patients who have or don’t have clasical risk factors (hypertension (HT), diabetes mellitus (DM), smoking, etc.), who describes chest pain and who are undergoing stress test. Study was performed in Istanbul Haseki Education and Research Hospital Treadmill stres Test Unit. Blood samples for hsCRP and NT-proBNP are taken before and after test. Results: As result we can say that Treadmill stress test increases significantly both biomarkers independent of all studied cardiovascular risk factors (p<0,001) and interstingly non-smokers had higher NT-proBNP levels wich is controversial to the references (p=0,013). Conclusion: We can conclude that more studies with more patients and enduring observations are needed to be done to determine what causes these results.
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Abstract (Original Language): 
Amaç: Kardiyovasküler hastalıklar günümüzde halen küresel ölçekte mortalite ve morbiditenin en önemli nedeni olup, yüksek riskteki bu popülasyonu belirlemek, tedavi etmek ve güvenilir bir şekilde prognozu öngörebilmek için kullanılabilecek belirteçler klinikte büyük öneme sahiptir. Güncel bilgiler hsCRP ve NT-proBNP nin koroner arter hastalığı (KAH) olan hastalarda eşsiz prognostik bilgi sağladığını göstermektedir. Çalışmanın amacı, hsCRP ve NT-proBNP’nin birlikte kullanılmasının KAH şüphesi olan hastalarda kardiyovasküler olayları tespit etmede klinik fayda sağlayıp sağlamayacağının değerlendirilmesidir. Gereç ve Yöntem: Çalışmamız koroner arter hastalığının geleneksel risk faktörlerini (hipertansiyon (HT), diyabetes mellitus (DM), sigara vs) taşıyan yada taşımayan, göğüs ağrısı tarifleyen ve eforlu EKG testi ile değerlendirilmesi istenen 81 hasta üzerinde yapıldı. Ekim-2008 ayında İstanbul Haseki Eğitim Araştırma Hastanesi Eforlu EKG Ünitesinde gerçekleştirildi. Hastaların test öncesi ve sonrası kan örneklerinde hsCRP ve NT-proBNP düzeyleri bakıldı. Bulgular: Efor testinin, incelediğimiz tüm kardiyovasküler risk faktörlerinden bağımsız olarak hsCRP ve NT-proBNP düzeylerini anlamlı olarak (p<0,001) arttırdığı sonucuna ulaşıldı. Ayrıca beklenenin aksine sigara içmeyenlerde (p:0,013) NT-proBNP düzeylerinin daha fazla arttığı saptandı. Sonuç: Sonuçlar ilgi çekicidir. Elde ettiğimiz bu sonuçları daha net yorumlayabilmek için, denek sayısının arttırılması ve daha uzun süreli takip gibi faktörlere gerek olabilir diye düşünmekteyiz.
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  • Turkish

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İletişim:
Uz.Dr. Mehmet Burak Aktuğlu
Haseki Eğitim ve Araştırma Hastanesi Dahiliye Kliniği
Fecri Ebcioğlu sokak.Dilek Apt. No: 6/7
1.Levent-İstanbul.
Tel: +90.505.7734483
e-posta: lifeiner@yahoo.com

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