1- Maffei M, Fei H, Lee GH ,Dani C, Leroy P, Zhang Y, et al. Increased expression in adipocytes ofob RNA in mice with lesions ofthe hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 1995; 92: 6957-60.
2- Flier JS. The adipocyte: storage depot or node on the
S.D.Ü. Tıp pak.
Derg
. 2007:14(2)/ 51-55
54
Özbalcı, Nöroprotektif tedavide ikinci jenerasyon tetrasiklinler
energyinformationsuperhighway?. Cell 1995; 80: 15¬8.
3- Tartaglia, LA, Demski M, Weng X, Deng NH, Culpepper J, Devos R, et al. Identification and expression ofcloning ofa leptin receptor OB-R. Cell 1995; 83: 1263-1271.
4- Lee GH, Proenza R, Montez JM, Carroll KM, Darvishzadch JG, Lee JL et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 39:
632-635.
5- Pelleymounter MA., Cullen MJ., Baker MB., Hecht R., Winters D., Boone T. et al. Effects ofthe obese gene product on body weight regulation in ob/ob mice. Science 1995;269, 540-543.
6- Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB and Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet induced resistance to leptin action. Nat. Med. 1995; 1: 1311¬1314
7- Maffuci M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, et al. Leptin levels in human and rodent: measurement ofplasma leptin and ob RNA in obese andweightreducedsubjects.Nat. Med. 1995; 1: 1115¬1161.
8- Faggioni R, Feingold KR, Grunfeld C. Leptin regulation ofthe immune response and the immunodefiency of malnutrion. FASEB 2001 Symposium 'Nutrients as regulators ofthe Immune System'.
9- Siegrist-Kaiser CA, Pauli V, Juge-Aurby CE, Boss O, Pernin A, Chin WW, et al. Direct effects of leptin on brownandwhiteadiposetissue. JClin.Invest: 1997; 100: 2858-2864.
10- Chandra RK. Cell mediated immunity in genetically obese C57BL/6J ob/ob mice. Am. J. Clin. Nutr. 1980; 33: 13-16.
11- Spicer LJ, Francisco CC. The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology 1997; 138: 3374¬3379.
12- Pralong FP, Roudit R, Waeber G, Castillo E, Mosimann F, Thorens B, et al. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology 1998; 139: 4264-4268.
13- Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper C, Devos R et al. Identification and expression cloning of a leptin receptor. Cell 1995; 83: 1263-71.
14- Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000;
269:543-6
15- Siegmund B, Lehr HA, Fantuzzi G. Leptin: a pivotal mediator ofintestinal inflammation in mice. Gastroenterology2002; 122: 2011-25.
16- Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA et al. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 1999;
104: 1051-9.
17- FujitaY, Murakami M, OgawaY, Masuzaki H, Tanaka M, Ozaki S et al. Leptin inhibits stress-induced apoptosis ofT lymphocytes. Clin Exp Immunol 2002; 128:21¬6.
18- Faggioni R, Jones-Carson J, Reed DA, Dinarello CA, Feingold KR, Grunfeld C et al. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity. Role oftumor necrosis factor alpha and IL-18. Proc Natl Acad Sci USA 2000; 97: 2367-72.
19- Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000 Oct; 68(4): 437-46
20- Frederich RC, Lollmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB et al. Expression of Ob mRNA and its encoded protein in rodents. Impact ofnutritionandobesity. JClinInvest 1995; 96:1658-63.
21- Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR, et al. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am. J. Physiol. 1999; 276: 136-142.
22- Gainsford T, Wilson TA, MetcalfD, Handman E, Mc Farlane C, Ng A et al. Leptin can induce proliferation, differantiation, and functional activation ofhemopoetic cells. Proc Natl Acad Sci USA 1996; 93: 14564-8.
23- Loffreda S, Rai R, Yang SQ el a\. Leptin regulates proinflammatory immune responses. FASEB J 1998; 12: 57-65.
24- Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M. and Friendman JM. Leptin activation of Stat3 in the hypothalamus ofwild-type and ob/ob mice but not db/db mice. Nat. Genet. 1996; 14: 95-97.
25- Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Haring HU. Leptin activates PI-3 kinase in C2C12 myotubes viajanus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 1997; 40: 1358-62.
26- Martin-Romero C, Santos-Alvarez J, Goberna R, Sânchez-Margalet V. Human leptin enhances activation and proliferation ofhuman circulating T lymphocytes. Cell Immunol 2000; 199: 15-24.
27- Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin stimulates proliferation and activation ofhuman circulating monocytes. Cell Immunol 1999; 194: 6-11
28- Scheinbenbogen C, Keilholz U, Richter M, Andressen R, Hunstein W. The interleukin-2 receptor in human monocytes and macrophages: regulation ofexpression and release ofthe alpha and beta chains (p55 and p75). Res Immunol 1992; 143: 33-7.
29- Czerniecki BJ, Carter C, Rivoltini L, Koski GK, Kim HI, Weng DE et al. Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics ofactivated dendritic cells. J Immunol 1997; 159: 3823-37.
S.D.Ü. Tıp pak.
Derg
. 2007:14(2)/ 51-55
Özbalcı, Nöroprotektif tedavide ikinci jenerasyon tetrasiklinler
55
30- Darcissac
EC
, Bahr GM, Parant MA, Chedid LA, Riveau GJ. Selective induction ofCD11a, b, c/CD18 and CD54 expression at the cell surface ofhuman leucocytes by muramyl peptides. Cell Immunol 1996; 169: 294-301.
31- De Maria R, Cifone MG, Trotta R, Rippo MR, Festuccia C, SAntoni A et al.. Triggering ofhuman monocyte activation through CD69, a member ofthe natural killer cell gene complex family of signal transducing receptors. J Exp Med 1994; 180:1999-2004.
32- Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, et al. Leptin regulates proinflammatory immune responses. FASEB J. 1998; 12: 57-65.
33- Lee FY, Li Y, Yang EK, Yang SQ, Lin HZ, Trush MA, et al. Phenotypic abnormalities in macrophages from leptin deficient, obese mice. Am. J. Physiol. 1999; 276: 386-394.
34- Zarkesh E, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, et al. High-dose leptin activates human leucocytes via receptor expression on monocytes. J Immunol. 2001; 167: 4593-4599.
35- Gabay C, Smith MF, Eidlen D, Arend WP. Interleukin 1 receptor antagonist (IL-1Ra) is an acute phase protein. J. Clin. Invest. 1997; 99: 2930-2940.
36- Luheshi GN, Gardner JD, Rushford DA, Loudon AS, Rothwell NJ. Leptin actions on food intake and body temperature are mediated by IL-1. Proc Natl. Acad. Acad. Sxi. USA 1999; 96: 7047-7052.
37- Taub DD, Lloyd AR, Conlon K, Wang JM, Ortaldo JR, Harada A, et al. Recombinant human interferon-inducible protein 10isa chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesionto endothelialcells. J. Ex. Med. 1993; 177: 1809-1814.
38- Juge-Aubry CE, Meier CA. Immunomodulatory action ofleptin. Molecular and Cellular Endocrinology 2002; 194: 1-7.
39- Lord GM, Materese G, Howard JK, Bloom SR Lechler RI. Leptin inhibits the anti-CD3-driven proliferation ofperipheral blood T cells but enhances the production ofproinflammatory cytokines. J Leukoc Biol 2002; 72: 330-8
40- Lord GM, Materese G, Howrad JK, Baker RJ, Bloom SR, and Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosupression. Nature (London) 1998; 394: 897¬901.
41- Meier CA, Bobbioni E, Gabey C, Assimacopoulos-jeannet F, Golay A, Dayer JM. Interleukin-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin? J. Clin. Endocrinol. Metab 2002; 87: 1184-1188.
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