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Dental amalgamm insan organizması üzerindeki etkileri

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Abstract (2. Language): 
Dental amalgam is one of the oldest restorative materials used in dentistry, but it's not an esthetical material. In recent years, new resin-based restorative materials were producted in dentistry and using of amalgam was decreased. purthermore, amalgam has just high using rates in a lot of dental clinics. It's suggested that, there's a continious release of mercury from amalgam restorations and this releasing may cause a potential risk for patients and dentists and contribute to development of some diseases such as loss of weight, tremor, gastrointestinal disturbances, oral lichenoid lesions, teratogenic effects, Multiple-Sclerosis ve Alzheimer's Disease. In several studies it was shown that, levels of mercury released from amalgam restorations were in lower doses than high levels of mercury which caused to health risk. Mercury has a possible toxicity risk for dental personal, but it's reported that, it may prevented if a good mercury hygene was performed in clinics carefully.
Abstract (Original Language): 
Dental amalgam, di ş hekimliğinde kullanılan en eski dolgu maddelerinden biri olan, ancak estetik olmayan bir materyaldir. Son yıllarda, diş hekimliğinde, yeni rezin-bazlı restoratif materyaller üretilmiş ve amalgamın kullanımı eskiye oranla azalmıştır. Bununla birlikte amalgam, halen pek çok diş hekimliği kliniğinde yüksek kullanım oranlarına sahiptir. Son yıllarda, amalgam restorasyonlardan salınan civanın, vücut üzerinde bir takım olumsuz etkilere neden olabileceği ve hastalar ve diş hekimleri için potansiyel risk oluşturarak; kilo kaybı, tremor, gastrointestinal bozukluklar, likenoid lezyonlar, teratojenik etkiler, Multipl-Sklerozis ve Alzheimer Hastalığı gibi hastalıklara yol açabileceği ileri sürülmüştür. Ancak yapılan araştırmalarda, amalgam dolgulardan salınan civanın, hastalar için hayati risk oluşturabilecek yüksek seviyelerden çok daha düşük dozlarda olduğu gösterilmiştir. Diş hekimliği personeli için ise civa, toksisite riskine sahiptir, ancak dental kliniklerde civa hijyenine titizlikle dikkat edildiği takdirde, bu riskin tamamiyle önlenebileceği bildirilmektedir.
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REFERENCES

References: 

1- Dental amalgam: Update on safety concerns. ADA Council on scientific affairs. J Am Dent Assoc
S.D.Ü. Tıp pak.
Derg
. 2007:14(3)/ 52-61
Küçükeşmen, Amalgamın insan organizması üzerine etkileri
57
1998; 129 (4): 494-503.
2-
Çola
k Ş. Amalgam: Dünü ve bugünü. AÜ. Diş Hek. Fak. Derg. 1989; 16 (3): 533-8.
3-
Bayırl
ı G, Şirin Ş. Konservatif diş tedavisi. Dünya Tıp Kitapevi. 1982; Sf: 130-45.
4- Berglund A, Molin M. Mercury levels in plasma and urine after removal of all amalgam restorations: the effect of using rubber dams. Dent Mater 1997; 13(5): 297-304.
5- Eley BM. The future of dental amalgam: a review of the literature. Part 7: Possible harmful effects of mercury from dental amalgam. Br Dent J 1997;182 (12)1:455-9.
6- Dye BA, Schober SE, Dillon CF, Jones RL, Fryar C, McDowell M, Sinks TH. Urinary mercury concentrations associated with dental restorations in adult women aged 16-49 years: United States, 1999-2000. Occup Environ Med 2005; 62(6):
368-75.
7- Mitchell RJ, Osborne PB, Haubenreich JE. Dental amalgam restorations: daily mercury dose and biocompatibility. J Long Term EffMed Implants 2005; 15(6): 709-21.
8- Chin G, Chong J, Kluczewska A, Lau A, Gorjy S, Tennant M. The environmental effects of dental amalgam. Aust Dent J 2000; 45(4): 246-9.
9- Counter SA, Buchanan LH. Mercury exposure in children: a review. Toxicol Appl Pharmacol 2004; 15; 198 (2): 209-30.
10- Langan D.C, Fan P.L, Hoos A.A. The use of mercury in dentistry: a critical review of the recent literature.JAmDentAssoc 1987; 115 (6): 867¬80.
11- Yip HK, Li DK, Yau DC. Dental amalgam and human health. Int Dent J 2003; 53 (6): 464-8.
12- Godfrey ME, Wojcik DP, Krone CA. Apolipoprotein E genotyping as a potential biomarker for mercury neurotoxicity. J Alzheimers Dis 2003;5(3): 189-95.
13- Langworth S, Bjorkman L, Elinder CG, Jarup L, Savlin P. Multidisciplinary examination of patients with illness attributed to dental fillings. J Oral Rehabil 2002; 29 (8): 705-13.
14- Khordi-Mood M, Sarraf-Shirazi AR, Balali-Mood M. Urinary mercury excretion following amalgam filling in children. J Toxicol Clin Toxicol 2001; 39(7): 701-5.
15- Mutter J, Naumann J, Sadaghiani C, Walach H, Drasch G. Int J Environ Health Amalgam studies: disregarding basic principles of mercury toxicity. Int J Hyg Environ Health 2004; 207 (4): 391-7.
16- Brownawell AM, Berent S, Brent RL, Bruckner JV, Doull J, Gershwin EM, Hood RD, Matanoski GM, Rubin R, Weiss B, Karol MH. The potential adverse health effects of dental amalgam. Toxicol Rev2005; 24(1): 1-10.
17- Zaimoğlu A, Can G, Ersoy E, Aksu l: Diş hekimliğinde maddeler bilgisi. Ankara Üniversitesi Basımevi.1993; Sf: 261-304.
18- Nakajima H,
Watah
a JC, Rockwell LC, Okabe T. In vitro cytotoxicity of amalgams made with binary Hg-In liquid alloys. Dent. Mater. 1997; 13: 168-73.
19- Eley BM. The future of dental amalgam: a review of the literature. Part 1: Dental amalgam structure and corrosion. Br Dent J 1997; 182 (7): 247-9.
20- Martin MD, Broughton S, Drangsholt M. Oral lichen planus and dental materials: a case-control study. Contact Dermatitis 2003; 48 (6): 331-6.
21- Sutow EJ, Maillet WA, Taylor JC, Hall GC. In vivo galvanic currents of intermittently contacting dental amalgam and other metallic restorations. Dent Mater 2004; 20 (9): 823-31.
22- Clarkson TW. The three modern faces of mercury. Environmental Health Perspectives 2002; 110
(1):11-23.
23- Eley BM. The future of dental amalgam: a review of the literature. Part 4: Mercury exposure hazards and risk assessment. Br Dent J 1997; 182 (10):
373-81.
24- Eley BM, Cox SW. Mercury from dental amalgam fillings in patients. Br Dent J 1987; 163 (7): 221¬6.
25- Ekstrand J, Björkman L, Edlund C, Sandborgh-Englund G. Toxicological aspects on the release and systemic uptake of mercury from dental amalgam. Eur J Oral Sci 1998; 106: 678-86.
26- Aoyagi H, Katagiri M. Long-term effects of Ag-containing alloys on mucous tissue present in biopsy samples. Dent Mater J 2004; 23 (3): 340¬7.
27- Danscher G, Horsted-Bindslev P, Rungby J. Traces of mercury in organs from primates with amalgam fillings. Exp Mol Pathol 1990; 52: 291-9.
28- Pizzichini M, Fonzi M, Giannerini F, Mencarelli M, Gasparoni A, Rocchi G, Kaitsas V, Fonzi L. Influence of amalgam fillings on Hg levels and total antioxidant activity in plasma ofhealthy donors. Sci Total Environ 2003; 1;30 (1-3): 43¬50.
29- Hol PJ, Vamnes JS, GierdetNR, Eide R, Isrenn R. Dental amalgam and selenium in blood. Environ
S.D.Ü. Tıp pak.
Derg
. 2007:14(3)/ 52-61
58
Küçükeşmen, Amalgamın insan organizması üzerine etkileri
Res 2001; 87 (3): 141-6.
30- Saxe SR, Wekstein MW, Kryscio RJ, Henry RG, Cornett CR, Snowdon DA, Grant FT, Schmitt FA, Donegan SJ, Wekstein DR, Ehmann WD, Markesbery WR. Alzheimer's disease, dental amalgam and mercury. J Am Dent Assoc 1999; 130(2): 191-9.
31- Nlander M, Friberg L, Lind B. Mercury concentrations in the human brain and kidneys in relation to exposure from dental amalgam fillings. In: Eley BM. The future of dental amalgam: a review of the literature. Part 5: Mercury in the urine, blood and body organs from dental amalgam fillings. Br Dent J 1997; 182 (11): 413-7.
32- Mortada WI, Sobh MA, el-Defrawy MM, Farahat SE. Reference intervals of cadmium, lead, and mercury in blood, urine, hair, and nails among resident in Mansoura city, Nile delta, Egypt. Environ Res 2002; 90 (2): 104-10.
33- Eley BM. The future of dental amalgam: a review of the literature. Part 5: Mercury in the urine, blood and body organs from dental amalgam fillings. Br Dent J 1997; 182 (11): 413-7.
34- Sandborgh-Englund G, Elinder C-G, Langworth S, Schütz A, Ekstrand J. Mercury in biological fluids after amalgam removal. J Dent Res 1998; 77(4): 615-24.
35- Skoner JR, Wallace JA, Fochtman F, Moore PA, Zullo T, Hoffman D. Blood mercury levels with amalgam retroseals: A longitudinal study. J Endod. 1996; 22 (3): 140-1.
36- Bjornberg KA, Vahter M, Grawe KP, Berglund M. Methyl mercury exposure in Swedish women with high fish consumption. Sci Total Environ 2005; 1; 341 (1-3): 454-52.
37- Eley BM, Cox SW. The release, absorption and possible health effects of mercury from dental amalgam: a review of recent findings. Br Dent J 1993; 175 (10): 355-62.
38- Abraham JE, Svare CW, Frank CW. The effect of dental amalgam restorations on blood mercury levels. J Dent Res 1984; 63:71-3.
39- Snapp KB, Boyer DB, Peterson LC, Svare CW. The contribution of dental amalgam to mercury in the blood. J Dent Res 1989; 68: 780-5.
40- Karahalil B, Rahravi H, Ertas N. Examination of urinary mercury levels in dentists in Turkey. Hum Exp Toxicol 2005; 24 (8): 383-8.
41- Mandel ID. Amalgam hazards an assessment of research. J Am Dent Assoc 1991; 122 (8): 62-5.
42- Fung YK, Molvar MP, Strom A, Schneider NR,
Carlson MP. In vivo mercury and methyl mercury levels in patients at different intervals after amalgam restorations. In: Eley BM. The future of dental amalgam: a review of the literature. Part 5: Mercury in the urine, blood and body organs from dental amalgam fillings. Br Dent J 1997; 182 (11): 413-7.
43- Bellinger DC, Trachtenberg F, Barregard L, Tavares M, Cernichiari E, Daniel D, Mc Kinlay S. Neuropsychological and renal effects of dental amalgam in children: a randomized clinical trial. JAMA 2006; 19; 295 (15): 1775-83.
44- Kingman A, Albertini T, Brown LJ. Mercury concentrations in urine and whole blood associated with amalgam exposure in a US military population. J Dent Res 1998; 77 (3): 461-71.
45- Olstad ML, Holland RI, Wandel N, Hensten Pettersen A. Correlation between amalgam restorations and mercury concentrations in the urine. J Dent Res 1987; 66: 1179-82.
46- Leistevuo J, Leistevuo T, Helenius H, Pyy L, Huovinen P, Tenovuo J. Mercury in saliva and the risk of exceeding limits for sewage in relation to exposure to amalgam fillings. Arch Environ Health 2002; 57 (4): 366-70.
47- Sweeney M, Creanor SL, Smith RA, Foye RH. The release of mercury from dental amalgam and potential neurotoxicological effects. J Dent 2002; 30 (5-6): 243-50.
48- Ganss C, Gottwald B, Traenckner I, Kupfer J, Eis D, Monch J, Gieler U, Klimek J. Relation between mercury concentrations in saliva, blood, and urine in subjects with amalgam restorations. Clin Oral Investig2000;4(4):206-11.
49- Egglestone DW, Nylander M. Correlation of dental amalgam with mercury in brain tissue. J Prosthet Dent 1987; 58: 704-7.
50- Eley BM. The future of dental amalgam: a review of the literature. Part 2: Mercury exposure in dental practice. Br Dent J 1997;182 (8): 293-7.
52- Langworth S, Stromberg R. A case ofhigh mercury exposure from dental amalgam. Eur J Oral Sci 1996; 104 (3): 320-1.
53- DeRouen TA, Martin MD, Leroux BG, Townes BD, Woods JS, Leitao J, Castro-Caldas A, Luis H, Bernardo M, Rosenbaum G, Martins IP. Neurobehavioral effects of dental amalgam in children: a randomized clinical trial. J Am Med Assoc 2006; 19;295 (15): 1784-92.
54- Dalen K, Lygre GB, Klove H, GjerdetNR, Askevold E. Memory functions in persons with
S.D.Ü. Tıp pak.
Derg
. 2007:14(3)/ 52-61
Küçükeşmen, Amalgamın insan organizması üzerine etkileri
59
dental amalgam. J Dent 2003; 31 (7): 487-92.
55- Factor-Litvak P, Hasselgren G, Jacobs D, Begg M, Kline J, Geier J, Mervish N, Schoenholtz S, Graziano J. Mercury derived from dental amalgams and neuropsychologic function. Environ Health Perspect 2003; 111 (5): 719-23.
56- Kingman A, Albers JW, Arezzo JC, Garabrant DH, Michalek JE. Amalgam exposure and neurological function. Neurotoxicology 2005; 26 (2): 241-55.
57- Maeda H, Hashiguchi I, Nakamuta H, Toriya Y, Wada N, Akamine A. Histological study of periapikal tissue healing in the rat molar after retrofilling with various materials. J Endod 1999; 25 (1): 38-42.
58- Bates MN. Mercury amalgam dental fillings: An epidemiologic assessment. Int J Hyg Environ Health2006; 209(4): 309-16.
59- Lygre GB, Gjerdet NR, Gronningsaeter AG, Bjorkman L. Reporting on adverse reactions to dental materials-intraoral observations at a clinical follow-up. Community Dent Oral Epidemiol 2003; 31 (3):200-6.
60- Garhammer P, Schmalz G, Hiller KA, Reitinger T, Stolz W. Patients with local adverse effects from dental alloys: frequency, complaints, symptoms, allergy. Clin Oral Investig 2001; 5 (4):
240-9.
61- Laeijendecker R, Dekker SK, Burger PM, Mulder PG, Van Joost T, Neumann MH. Oral lichen planus and allergy to dental amalgam restorations. Arch Dermatol 2004;140 (12): 1434-8.
62- Axell T. Hypersensitivity of the oral mucosa: clinics and pathology. Acta Odontol Scand 2001; 59 (5): 315-9.
63- Pigatto PD, Guzzi G, Persichini P, Barbadillo S. Recovery from mercury-induced burning mouth syndrome due to mercury allergy. Dermatitis 2004; 15(2): 75-7.
64- Fardal O, Johannessen AC, Morken T. Gingivo-mucosal and cutaneous reactions to amalgam fillings. J Clin Periodontol 2005; 32 (4): 430-3.
65- Ulukapi I. Mercury hypersensitivity from amalgam: report of case. ASDC J Dent Child 1995;62 (5):363-4.
66- Smrt ER, Macleod RI, Lawrence CM. Resolution of lichen planus following removal of amalgam restorations in patients with proven allergy to mercury salts: a pilot study. Br Dent J 1995; 178:
108-12.
67- Bergman M. Side-effects of amalgam and its
alternatives: local, systemic and environmental. IntDentJ 1990; 40:4-10.
68- Thornhill MH, Sankar V, Xu XJ, Barrett AW, High AS, Odell EW, Speight PM, Farthing PM. The role ofhistopathological characteristics in distinguishing amalgam-associated oral lichenoid reactions and oral lichen planus. J Oral Pathol Med 2006;35 (4):233-40.
69- Bratel J, Hakeberg M, Jontell M. Effect of replacement of dental amalgam on oral lichenoid reactions. J Dent 1996; 24 (1-2): 41-5.
70- Bolewska J, Hansen HJ, Holmstrup P, Pindborg JJ, Stangerup M. Oral mucosal lesions related to silver amalgam restorations. Oral Surg Oral Med Oral Pathol 1990; 70: 55-8.
71- Hultman P, Lindh U, Horsted- Bindslev P. Activation of the immune system and systemic immune-complex deposits in brown Norway rats with dental amalgam restorations. J Dent Res. 1998; 77 (6): 1415-25.
72- Podzimek S, Prochazkova J, Bultasova L, Bartova J, Ulcova-Gallova Z, Mrklas L, Stejskal VD. Sensitization to inorganic mercury could be a risk factor for infertility. Neuro Endocrinol Lett 2005; 26 (4): 277-82.
73- Mackert JR Jr, Leffell MS, Wagner DA, Powell BJ. Lymphocyte levels in subjects with and without amalgam restorations. J Am Dent Assoc 1991; 122 (3): 49-53.
74- Bratel J, Haraldson T, Meding B, Yontchev E, Ohman SC, Ottoson JO. Potential side effects of dental amalgam restorations (I). An oral and medical investigation. Eur J Oral Sci 1997; 105 (3): 234-43
75- Vimy MJ, Takahashi Y, Lorscheider FL. Maternal-
203
fetal distribution of mercury ( Hg) released from dental amalgam fillings. Am J Physiol 1990;
258:R939-45.
76- Holmes AS, Blaxill MF, Haley BE. Reduced levels of mercury in first baby haircuts of autistic children. Int J Toxicol 2003; 22 (4): 277-85.
77- Takahashi Y, Tsuruta S, Arimoto M, Tanaka H, Yoshida M. Placental transfer of mercury in pregnant rats which received dental amalgam restorations. Toxicology2003; 14; 185 (1-2): 23¬33.
78- Takahashi Y, Tsuruta S, Hasegawa J, Kameyama Y, Yoshida M. Release of mercury from dental amalgam fillings in pregnant rats and distribution of mercury in maternal and fetal tissues. Toxicology 2001; 21: 163 (2-3): 115-26.
S.D.Ü. Tıp pak.
Derg
. 2007:14(3)/ 52-61
60
Küçükeşmen, Amalgamın insan organizması üzerine etkileri
79- Morgan DL,
Chand
a SM, Price HC, Fernando R, Liu J, Brambila E, O'Connor RW, Beliles RP, Barone S Jr. Disposition of inhaled mercury vapor in pregnant rats: maternal toxicity and effetcs on developmental outcome. Toxicol Sci 2002; 66 (2): 261-73.
80- Luglie PF, Campus G, Chessa G, Spano G, Capobianco G, Fadda GM, Dessole S. Effect of amalgam fillings on the mercury concentration in human amniotic fluid. Arch Gynecol Obstet 2005; 271 (2): 138-42.
81- Hujoel PP, Lydon-Rochelle M, Bollen AM, Woods JS, Geurtsen W, del Aquila MA. Mercury exposure from dental filling placement during pregnancy and low birth weight risk. Am J Epidemiol 2005; 15; 161 (8): 734-40.
82- Evens CC, Martin MD, Woods JS, Soares HL, Bernardo M, Leitao J, Simmonds PL, Liang L, DeRouen T. Examination of dietary methylmercury exposure in the Casa Pia Study of the health effects of dental amalgam in children. J Toxicol Environ Health A 2001; 7; 64 (7): 521¬30.
83- Gibbons DE, Higgs R, Gelbier S. Ethics ofthe theoretical risk. Br Dent J 1998; 185 (2): 58-9.
84- Brown D. Amalgam use in pregnant women. Br DentJ 1998; 184 (11): 524-5.
85- Carta P, Flore C, Ibba A, Tocco M, Aru G, Mocci
F, Sana FR. Urinary and blood markers of internal mercury dose in workers from a chlorakali plant and in subjects not occupationally exposed: relation to dental amalgam and fish consumption. Med Lav 2002; 93 (3): 176-83.
86- Wennberg M, Lundh T, Bergdahl IA, Hallmans
G, Jansson JH, Stegmayr B, Custodio HM, Skerfving S. Time trends in burdens of cadmium, lead, and mercury in the population of nothern Sweden. Environ Res 2006; 100 (3): 330-8.
87- SorensenN, Murata K, Budtz-Jorgensen E, Weihe P, Grandjean P. Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age. Epidemiology 1999; 10 (4): 370-5.
88- Warfinge K. Mercury exposure of a female dentist before pregnancy. Br Dent J 1995; 25;178 (4):
149-52.
89- HanfV, ForstmannA, Costea JE, Schieferstein G, Fischer I, Schweinsberg F. Mercury in urine and ejaculate in husbands ofbarren couples. Toxicol Lett 1996; 88 (1-3): 227-31.
90- Aleser KH, Brix KA, Fine LJ, Kallenbach IR, Wolfe RA. Occupational mercury exposure and
male reproductive health. Am J Indust Med 1989; 15: 517-29.
91- Souza AP, Gerlach RF, Line SR. inhibition of human gelatinases by metals released from dental amalgam. Biomaterials 2001; 22 (14): 2025-30.
92- Tai KW, Chang YC. Cytotoxicity evaluation of perforation repair materials on human periodontal ligament cells in vitro. J Endod 2000; 26 (7): 395¬7.
93- Lin CP, Chen YJ, Lee YL, Wangs JS, Chang MC, Lan WH, Chang HH, Chao WM, Tai TF, Lee MY, Lin BR, Jeng JH. Effects of root-end filling materials and eugenol on mitochondrial dehydrogenase activity and cytotoxicity to human periodontal ligament fibroblasts. J Biomed Mater Res B Appl Biomater 2004; 15;71 (2):429-40.
94- Keiser K, Johnson CC, Tipton DA. Cytotoxicity of mineral trioxide aggregate using human periodontal ligament fibroblasts. J Endod 2000; 26 (5): 288-91.
95- Haglund R, He J, Jarvis J, Safavi KE, Spangberg LS, Zhu Q. Effects of root-end filling materials on fibroblasts and macrophages in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95 (6): 739-45.
96- Pistorius A, Willershausen B, Briseno Marroquin B. Effect of apical root-end filling materials on gingival fibroblasts. Int Endod J 2003; 36 (9):
610-5.
97- Makkavy HA, Koka S, Lavin MT, Ewoldsen NO. Cytotoxicity of root perforation repair materials. JEndod 1998;24 (7):477-9.
98- Mutter J, Naumann J, Sadaghiani C, Schneider R, Walach H. Alzheimer disease: mercury as pathogenetic factor and apolipoprotein Easa moderator. Neuro Endocrinol Lett 2004; 25 (5):
331-9.
99- Brodsky JB, Cohen EN, Whitcher C, Brown BW Jr, Wu ML. Occupational exposure to mercury in dentistry and pregnancy outcome. J Am Dent Assoc 1985; 111 (5): 779-80.
100- Thorp JM, Boyette DD, Watson WJ, Cefalo RC. Elemental mercury exposure in early pregnancy. Obstet Gynecol 1992; 79: 874-6.
101- Ericson A, Kallen B. Pregnancy outcome in women working as dentists, dental assistants or dental technicians. Int Arch Occup Environ Health 1989; 61 (5): 329-33.
102- Ritchie KA, Gilmour WH, Macdonald EB, Burke FJ, McGowan DA, Dale IM, Hammersley R, Hamilton RM, Binnie V, Collington D. Health
S.D.Ü. Tıp pak.
Derg
. 2007:14(3)/ 52-61
Küçükeşmen, Amalgamın insan organizması üzerine etkileri
61
and neuropsychological functioning of dentists exposed to mercury. Occup Environ Med 2002; 59 (5): 285-6.
103- ADA Council on Scientific Affairs. Dental mercury hygiene recommendations. J Am Dent Assoc2003; 134 (11): 1498-9.
104- Ritchie KA, Burke FJ, Gilmour WH, Macdonald EB, Dale IM, Hamilton RM, McGowan DA, Binnie V, Collington D, Hammersley R. Mercury vapour levels in dental practices and body mercury levels of dentists and controls. Br Dent J 2004; 27; 197 (10): 625-32; discussion.
105- Phrukkanon S, Burrow MF, Tyas MJ. Bonding of amalgam and a Gallium alloy to bovine dentin. Oper Dent 1998; 23 (4): 195-202.
106- Claire J, Williams PT. Shear strengths of a gallium alloy bonded to human enamel following nine different surface treatments. Dent Mater 2001; 17(2): 116-21.
107- Eley BM. The future of dental amalgam: a review of the literature. Part 7: Possible alternative materials to amalgam for the restoration of posterior teeth. Br Dent J 1997; 183 (1): 11-4.
108- Cottingham KJ. Sentimentalising apotential health risk. Br Dent J 1998; 185 (3): 110
109- Hume R, Bayne SC, Duke ES, Roulet JF, Zimmer S, Losche G, Noack M. What is the future of amalgam? Quintessence Int 1996; 27 (2): 136-41.
110- Dodes JE. The amalgam controversy. An evidence- based analysis. J Am Dent Assoc 2001; 132 (3): 348-56.
111- News/Question of the month. Do we need more research on the safety of amalgam and other materials? J Am Dent Assoc 1996; 127 (7): 856.
112- Bratel J, Haraldson T, Ottosson JO. Potential side effects of dental amalgam restorations (II). No relation between mercury levels in the body and mental disorders. Eur J Oral Sci. 1997; 105 (3): 244-50.
113- Eley BM. The future of dental amalgam: a review of the literature. Part 3: Mercury exposure from amalgam restorations in dental patients. Br Dent J 1997; 182 (9): 333-8.

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