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Prostat kanseri ve kronik prostatit ilişkisi

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The mechanism and etiology of prostate cancer development has not been clearly established up to date. The discovery of prostate specific antigen (PSA) has become a cornerstone in the prostate cancer diagnosis. PSA is an important organ specific tumor marker, however, it is not cancer specific. It is well known that hystopathologic changes develop in tissues where inflammation occurs. Infection and inflammation are complex response in which several pathways play role and some of these pathways are activated during the cancer process, as well. Chronic inflammation and chronic infections play important role in carcinogenesis of various organ (such as bladder, liver, colon, esophagus and stomach) and are considered to be etiologic factors in about 20% of cancers. Epidemiologic, hystologic and genetic studies suggests that there may be a relation between common conditions such as prostatitis and prostate cancer. As a conclusion, the conditions that trigger and sustain the inflammatory process may be very important for prostatic carcinogenesis.
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Abstract (Original Language): 
Bu güne kadar prostat kanseri gelişimine sebep olabilecek nedenler ve mekanizmalar bütün açıklığı ile ortaya konulamamıştır. Prostat spesifik antijen'in (PSA) keşfi prostat kanseri teşhisinde dönüm noktası olmuştur. PSA önemli bir tümör belirteci olmakla birlikte organa özgü olmasına karşın kansere özgü değildir. Vücutta meydana gelen enflamatuvar durumlarda enflamasyonun meydana geldiği yerdeki dokuda histopatolojik değişikliklerin ortaya çıktığı bilinmektedir. Enfeksiyon ve enflamasyon çok sayıda yolağın görev aldığı kompleks bir yanıt olup, bu yolakların bir kısmı kanserde de aktive olmaktadır. Kronik enflamasyon ve kronik enfeksiyon değişik organlarda (mesane, karaciğer, kolon, özofagus ve mide gibi) karsinogenezde rol almakta ve erişkinlerde görülen kanserlerin yaklaşık %20'sinde etiyolojik faktör olarak sorumlu tutulmaktadır. Yapılan epidemiyolojik, histopatolojik ve genetik araştırmalar prostatit ve prostat kanseri gibi sık görülen bu patolojiler arasında bir ilişki olabileceğini göstermektedir. Sonuçta, enflamatuvar süreci tetikleyen, idame ettiren koşullar prostatik karsinogenez açısından çok önemli olabilirler.
FULL TEXT (PDF): 
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  • 3
28-31
  • Turkish

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