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İmmün süpressif ratlarda entero endokrin sistem yanıtı

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2011

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Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Human body has lots of defense mechanisms. One of these mechanisms is the well-known mucosal immune system. Paneth cells exist in the small intestine and enteroendocrine cells are also a part of this mucosal immune system. In this study, we studied the response of these cells when the immune system was suppressed. In the present study, we used 14 wistar Albino rats and applied immune supression in half of them.The another half of the rats were used as a control group.The materials taken from the rats were evaluated by applying histologic technics. Paneth cells, enteroendocrin cells, granülles of mast cells and their numbers were examined. Although similar morphological characteristics were observed in both the paneth cells and the enteroendocrin cells in the immune supressed and the control group, an increase in the mast cells were observed. Coke and basillus were found to be existed in the cript lumene and were also in great number.This increasing in the suppression of immune system is the result of deficient defence mechanism. On the other hand, the increase in the mast cells might be the result of a compansatory defence mechanism.
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Abstract (Original Language): 
İnsan vücudunda pek çok savunma mekanizması mevcuttur. Bu savunma mekanizmalarından bir tanesi de mukozal immün sistemdir. İnce barsaklarda bulunan paneth hücreleri ve enteroendokrin hücreler de bu mukozal immün sistemin bir parçasıdır. Bu çalışmada İmmün sistem baskılandığında bu hücrelerin verdiği yanıt araştırılmıştır. Çalışmada 14 adet Wistar Albino sıçan kullanılıp yarısına immün süpresyon uygulandı. Diğer yarısı kontrol grubu olarak kullanıldı. Sıçanlardan elde edilen materyaller histolojik teknikler uygulanıp değerlendirildi. Paneth hücreleri, enteroendokrin hücreler, mast hücreleri granülleri ve sayıları incelendi. İmmün süpresyon uygulanan grupta paneth hücrelerinde ve enteroendokrin hücrelerde kontrol grubuyla aynı özelliklerde morfolojiler tespit edilmesine rağmen, mast hücrelerinde sayıca artış görülmüştür. Ayrıca kript lümeninde bulunan kok ve basiller çok fazla miktarda artmıştır. Bu artış immün sistemin baskılanması sonucu savunma mekanizmasının yeterince çalışamaması sebebiyle olmaktadır. Mast hücrelerindeki artışın savunma mekanizması kompanzasyonu için olduğu düşünülmüştür.
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