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Kadmiyum maruziyeti spinal refleks yanıtlarının amplitüdünü arttırır

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objective: Cadmium is an environmental pollutant and which is a potent inhibitor of voltage-dependent calcium channels. It has been shown that cadmium can causes functional disturbances in central and peripheral nervous system. In this study, it has been aimed to investigate the effects of cadmium on the spinal reflexes. Materials and Methods: pourteen, male rats were divided into two groups: Control and Cadmium. Control group animals received tap water and the rats of Cadmium group received cadmium as in the form of cadmium chloride (70 mg/L) diluted in their drinking water during the experimental period. At the end of the 60 days experimental period, the sciatic nerve was stimulated electrically with single pulses and the reflex potentials were recorded from the ipsilateral L5 ventral root. Results: After the statistical analysis, the reflex response amplitudes were significantly increased in Cadmium group in comparison to the Control group. Conclusion: Subchronic exposure to cadmium affects the rat's spinal reflex responses and extrapolation of these results to humans indicate similar possible consequences.
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Abstract (Original Language): 
Amaç: Kadmiyum çevresel bir kirletici ve voltaj bağımlı kalsiyum kanallarının potent bir inhibitörüdür. Kadmiyumun santral ve periferik sinir sisteminde fonksiyonel bozukluklara neden olabileceği gösterilmiştir. Bu çalışmada kadmiyumun spinal reflekslere etkisi araştırılmıştır. Gereç ve Yöntemler: 14 adet, erkek sıçan Kontrol ve Kadmiyum grubu olarak ikiye ayrılmıştır. Kontrol grubundaki hayvanlara içme suyu, Kadmiyum grubundaki hayvanlara ise kadmiyum klorür (70 mg/L) içme suyunda çözülerek 60 gün boyunca verilmiştir. Deneysel periyodun sonunda siyatik sinir elektriksel olarak uyarılarak L5 ventral kökünden refleks potansiyelleri kaydedilmiştir. Bulgular: İstatistiksel analiz sonrasında kadmiyum grubunun refleks yanıtlarının amplitüdleri, kontrol grubuna göre istatistiksel olarak anlamlı düzeyde artmış bulunmuştur. Sonuç: Kadmiyuma subkronik maruziyet spinal refleks yanıtlarını etkiler ve insanlarda da olası benzer sonuçları düşündürür.
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  • 2
60-63
  • Turkish

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