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Fenobarbital Uygulamasında Intravenöz ve Intraosseöz Yolların Karşılaştırılması

Comparison of Intravenous and Intraosseous Routes for The Administration of Phenobarbital

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
Status epilepticus (SE) is classically defined as a generalized tonic-clonic seizure lasting longer than 30 min. Prolonged seizure activity can result in irreversible cerebral injury. In addition, evidence suggests that the longer the duration of the seizure, the less likely the activity is to be controlled. IV access, however, is frequently difficult to achieve during the seizure. On the other hand, intraosseous (IO) access is available. In this study, phenobarbital was administered to rabbits using both IV and IO lines at the dose of 20 mg/kg. The levels of phenobarbital in the blood were measured and the results were compared. The plasma profile of phenobarbital was found to be in the therapeutic level when it was administered by IO route. It was concluded that the IO line appeared to be an alternative route to IV access in the administration of phenobarbital.
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Abstract (Original Language): 
Status epileptikus klasik olarak 30 dakikadan uzun süren jenaralize tonik-klonik nöbet olarak tarif edilir. Uzun süren nöbet aktivitesi irreversibl serebral hasar ile sonuçlanabilir. Üstelik, nöbet aktivitesinin uzun sürmesinin kontrol edilebilirliğini azalttığı yönünde kanıtlar vardır. Damar yolunun sağlanması nöbet esnasında sıklıkla zordur. Öte yandan intraosseöz yol (10) kullanıma hazırdır. Bu çalışmada, 20 mg/kg dozunda fenobarbital IV ve 10 yoldan tavşanlara uygulandı. Fenobarbital kan düzeyleri ölçüldü ve sonuçlar karşılaştırıldı. Fenobarbital plazma profilinin IO uygulamada terapötik seviyede olduğu görüldü. 10 yolun fenobarbital verilmesinde IV yola alternatif olabileceği sonucuna varıldı.
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  • 4
11-14
  • Turkish

REFERENCES

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