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Yüksek bakır ile çinkonun böbrek ve kalp üzerine etkileri

The Effects Of High Zinc And Copper On The Kidney and Heart

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The Effects Of High Zinc And Copper On The Kidney and Heart In this study, the effect of high levels of zinc and copper intakes on kidney and heart were searched. Seventy seven numbers Wistar Albino rats were used as material. Twelve numbers of these were separated as control animals while the others were used as experimental groups. In I. experimental group (13 rats) were supplemented with oral zinc (70 mg/kg), II. experimental group (13 rats) were supplemented with oral zinc (80 mg/kg), III. experimental group (13 rats) were supplemented with oral copper (10 mg/kg), IV experimental group (13 rats) were supplemented with oral copper (20 mg/kg), V. experimental group (13 rats) were supplemented with oral zinc (70 mg/kg) + copper (10 mg/kg) in drinking water for four weeks. Control group (12 rats) were drunk only drinking water. In conclusion, it seems that zinc accumulates especially in heart tissue but with high doses it also accumulates in kidneys as much as heart tissue. On the other hand, copper did not show any difference between heart and kidney tissues in terms of copper accumulation given together with or without zinc.
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Abstract (Original Language): 
Yüksek bakır ile çinkonun böbrek ve kalp üzerine etkileri Bu çalışmada, sıçanlarda yüksek çinko ile bakır alımının böbrek ve kalp üzerine etkileri araştırıldı. Yetmişyedi Wistar albino soyu sıçan gereç olarak kullanıldı. Bunların onikisi kontrol grubu olarak, geriye kalanlar ise deney grupları olarak ayrıldı. 1. deneme grubuna (13 sıçan) ağızdan çinko (70 mg/kg), II. deneme grubuna (13 sıçan) da ağızdan çinko (80 mg/kg), III. deneme grubuna (13 sıçan) ağızdan bakır (10 mg/kg), IV. deneme grubuna (13 sıçan) da ağızdan bakır (20 mg/kg), V. deneme grubuna (13 sıçan) ise ağızdan çinko (70 mg/kg) + bakır (10 mg/kg) dört hafta süreyle içme sularına katılarak verildi. Kontrol grubuna (12 sıçan) ise normal içme suyu verildi. Sonuç olarak çinko öncelikle daha çok kalpte, doz arttıkça ise böbrekte de kalpte olduğu kadar birikime uğramaktadır. Bakır ise hem böbrekte hem de kalpte tek başına veya çinko ile birlikte verildiğinde birikmektedir.
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  • 3
35-42
  • Turkish

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