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Ratlarda Rektal Midazolam ye Ketamin Uygulamasının Rektal Mukoza Üzerine Etkileri

The Effects of Rectal Midazolam and Ke tam ine to Rectal Mucosa in Rats

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The Effects Of Rectal Midazolam And Ketamin Administration On Rectal Mucosa In Rats. We investigated to histopathological effects of rectal midazolam and ketamin administration on rectal mucosa in rats that are widespread used in premedication of pediatric patients. This investigation was conducted on 47 Wistar albino rats weighing 220-250 gr randomly divided into three groups. None of drugs were administered to group N (n;10) rats evaluated as control group for histopathological examination. 0.5 mg.kg-1 midazolam, 6 mg.kg-1 ketamine were introduced rectally to group M (n:19) and group K (n:18), respectively. Group N and group M were assessed as normal, eight of the group K samples were found to be mildly hyperemic, 3 of the group K samples were evaluated as hyper-emic in gross examination. The difference between group NIK and group MIK were statistically significant regarding the lymphocyte-PMNL infiltration and oedema. Oedema and lymphocyte-PMNL infiltration were limited within the mucosa and submucosa and no pathological finding was observed in the other layers. We conclude that midazolam administration rectally for premedication is a reliable route as it does not lead to histopathological alterations; but administration of ketamine rectally should be investigated in detail both experimentally and clinically.
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Abstract (Original Language): 
Pediatrik olguların premedikasyonunda rektal uygulamada sık kullanılan midazolam ve ketaminin, rektal mukoza üzerindeki histopatolojik etkilerini ratlarda araştırdık. Araştırma ağırlıkları 220-250 gram arasında değişen toplam 47 adet Wistar albino rat rasgele üç gruba ayrılarak yapıldı. Grup N (n:10) radara rektal ilaç verilmedi ve histopatolojik tetkik için kontrol grubu olarak kullanıldı. Grup M (n:19) radara 0.5 mg.kg -1 midazolam, Grup K (n:18) ratlara 6 mg.kg -1 ketamin rektal uygulandı. Makroskobik incelemede; Grup N ve grup M normal, Grup K doku örneklerinin 3 tanesi hiperemik, 8 tanesi hafif hiperemik olarak değerlendirildi. Lenfosit-PNL infil-trasyonu ve ödem açısından Grup N/K ve Grup M/K arasında istatistiksel açıdan anlamlı fark saptandı. Ödem ve lenfosit-PNL infıltrasyonu mukozada ve submukozada sınırlıydı, diğer katlarda patolojik bulguya rastlanmadı. Premedikasyon amacıyla rektal midazolam kullanımının histopatolojik değişikliklere neden olmaması nedeniyle güvenilir bir yol olduğu; rektal ketamin kullanımının hem deneysel hem de klinik olarak daha ayrıntılı araştırılması gerektiği kanısındayız.
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