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Düzenli Saç Boyası Kullanıcısı olan Sağlıklı Türk Kadınlarında SCE Sıklık Analizi

SCE Frequency Analysis in the Lymphocytes of the Healthy Turkish Women who are Regular Users of Hair Dye

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Although hair dyes are widely used cosmetic agents, their toxic effect on DNA has not been entirely demonstrated. These are of primary importance in women, particularly those who are pregnant or lactating, since any potential toxic effect on DNA becomes more significant. On the other hand, compositions of hair dyes vary in different countries because of differences in regulations. Therefore, toxicity studies should be taken under consideration for every countries. In the present study, the potential geno-toxic effects of long term use of hair dyes (minimum 5 years) were investigated by means of incidence of sister chromatid exchange (SCE) using the peripheral blood lymphocytes of healthy Turkish women at 25-43 age range. The mean frequency of SCE in women using hair dyes (n=39, mean SCEslcell ± SD: 14.26 ± 3.05) was significantly higher (P < 0.0001) than that of the control group (n=24, mean SCEslcell ± SD: 8.5 ± 1.59). Regarding age, hair color, usage period and the frequency of hair dyeing there was no significant difference in the SCE scores. In conclusion, when used long period of time, hair dyes sold in Turkish markets have toxic effects on DNA, and we suggest that these preliminary data should also be confirmed by other toxicology detection methods.
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Abstract (Original Language): 
Saç boyası sık kullanılan bir kozmetik ajan olmasına rağmen, DNA üzerine tok-sik etkisi yeterince açık değildir. Kadınlarca daha sık kullanıldığından, özellikle hamilelik ve süt verme durumunda böyle bir toksik etki daha da önemli hale gelir. Öte yandan, saç boyalarının yapısı çeşitli ülkelerdeki kurallara göre değişiklik göstermektedirBu nedenle, bu olası toksik etki her ülkede araştırılmalıdır. Bu çalışmada, yaşları 25-43 arasında değişen sağlıklı Türk kadınlarının periferik lenfositlerinde sister chromatide exchange (SCE) yöntemi kullanılarak uzun süre (en az 5 yıl) saç boyası kullanımının genotoksik etkisinin olup olmadığı araştırıldı. Kontrol grubu ile (n=24, ortalama SCE sıklığı/hücre ± SD: 8.5 ± 1.59) karşılaştırıldığında ortalama SCE sıklığının saç boyası kullanan kadınlarda (n=39, ortalama SCE sıklığı/hücre ± SD: 14.26 ± 3.05) önemli derecede arttığı saptandı (P < 0.0001). Saç boyası kullanan kadınların yaşı, kullanım süresi, boyanın rengi ya da kullanım sıklığı dikkate alındığında SCE sonuçlarında önemli bir farklılık gözlenmedi. Sonuç olarak Türkiye'de satılmakta olan saç boyaları uzun süre kullanıldığında DNA üzerinde toksik etki oluşmakta olup bu öncül verilerin diğer toksikoloji testleriyle de doğrulanmasının faydalı olacağını düşünmekteyiz.
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