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Kolinerjik sistemin morfogenetik olaylarda ve kanser oluşumundaki rolü

The role of the cholınergıc system ın morphogenetıc events and cancer formation

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The components of the cholinergic system are: Choline acetyltransferase, acetylcholine, cholinesterases, cholinergic receptors. The classical role of this system is the conduction of impulses between the cells of the nervous system. During the embryonic period, the components of the cholinergic system are detected in various cells and tis¬sues independently from nerve conduction. Cholinesterases and cholinergic receptors have been found to appear transiently at the cells and tissues, especially of the early embryonic stage and disappear by the accom¬plishment of the morphological development of these cells and tissues. This finding shows that the choliner-gic system has played role in morphogenetic events like proliferation, differentiation and migration. This sys¬tem has been called as "the embryonic cholinergic system", because it has got function in the morphogenesis of the cells and tissues in the embryonic period, differently from the classical function of the cholinergic sys¬tem. AChE, BChE and muscarinic receptors which are among the components of the cholinergic system, have been found to be positive during the abnormal cell proliferation in malign diseases and no relation has been pro¬posed between these components and nerve conduction. Linear correlation has been stated to be present between the appearance of cholinesterases and muscarinic receptors and the abnormal cell proliferation in malign events.
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Abstract (Original Language): 
Kolinerjik sistemin komponentleri; kolinasetiltransferaz, asetilkolin, kolinesterazlar ve kolinerjik reseptörlerdir. Bu sistemin bilinen klasik rolü, sinir sistemi hücreleri arasındaki uyarıları taşımasıdır. Embriyonal dönemde kolinerjik sistemin komponentleri, sinir iletiminden bağımsız çeşitli doku ve hücrelerde tespit edilmiştir. Özellikle erken embriyonal dönemdeki hücrelerde ve dokularda kolinesterazların ve muskarinik reseptörlerin geçici olarak ortaya çıktığı, doku ve hücrelerin morfolojik gelişiminin tamamlanması ile bunların kaybolduğu gözlenmiştir. Bu, kolinerjik sistemin morfolojik olaylarda yani hücre proliferasyonu, diferensiasyonu ve migrasyonunda rol oynadığını gösteren bir bulgu olarak kabul edilmektedir. Kolinerjik sistemin klasik fonksiyonundan farklı olarak embriyonal dönemde doku ve hücrelerin morfogenezinde rol aldığı için bu sisteme ayrıca "embriyonal kolinerjik sistem" denilmiştir. Kolinerjik sistemin komponentlerinden asetilkolinesteraz, butirilkolinesteraz ve muskarinik reseptörler malign olaylardaki anormal hücre artışı sırasında da tespit edilmiş ve bu komponentler ile sinirsel ileti arasın¬da herhangi bir ilişki kurulamamıştır. Malign olaylardaki anormal hücre çoğalmaları ile kolinesterazların ve muskarinik reseptörlerin ortaya çıkışı arasında doğrusal bir ilişkinin olduğu belirtilmektedir.
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  • 3
14-17
  • Turkish

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