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MANTAR ZEHİRLENMELERİNDE EKSTRAKORPORAL TEDAVİLER

EXTRACORPORAL TECHNIQUES IN THE TREATMENT OF MUSHROOM POISONING

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Poisoning by cytotoxic mushrooms is associated with severe morbidity and a high mortality rate. Due to the poor knowledge of the pharmacodynamics of toxins, there are conflicting results about appropriate treatment, particularly the efficacy of detoxification. The detoxification treatment should ideally be initiated early to minimize the toxic exposure of highly susceptible cells. Therapeutic strategy comprises elimination methods such as gastrointestinal lavage, charcoal administration, forced diuresis and extracorporeal detoxification techniques. Among these techniques, hemoperfusion and plasmapheresis are the most effective procedures of all. Early and comprehensive treatment are essential.
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Abstract (Original Language): 
Sitotoksik mantar zehirlenmeleri ciddi mm-bidite ve yüksek mortalite oranlan ile ortaya çıkmaktadır. Toksinlerin farmakodinamisine ait bilgilerin yetersizliğine bağlı olarak, özellikle detoksifikasyon etkinliği açısından, en uygun tedavi konusunda yanıltıcı sonuçlara ulaşılmıştır. Duyarlılığı yüksek olan hücrelerdeki toksik hasarı en aza indirmek amacıyla, detoksifikasyon tedavisi erken dönemde başlatılmalıdır. Tedavi stratejisini gastrointestinal lavaj, aktif kömür uygulaması, zorlu diürez ve ekstrakorporal detoksifikasyon teknikleri gibi eliminasyon yöntemleri oluşturur. Bu tekniklerin içinde, en etkin olanları hemoperfüzyon ve plazmaferezdir. Erken ve kapsamlı tedavi yaşamsal önem taşır.
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  • Turkish

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