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HEMODİYALİZ VE PERİTON DİYALİZİNİN OKSİDATİF STRES PARAMETRELERİ ÜZERİNE ETKİSİ

THE EFFECTS OF HEMODIALYSIS AND PERITONEAL DIALYSIS ON OXIDATIVE STRESS PARAMETERS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The importance of increase in the level of free oxygen species is well known in the development of complications during chronic renal failure. Insufficiency of antioxidant systems or increased production is responsible from high levels of oxidation products. Oxidative stress increases in dialysis treatment. In this study, the effects of hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) on the levels of plasma malondialdehyde (MDA), an indicator of lipid peroxydation and the antioxidant system enzymes, erythrocyte glutation peroxydase (GPx) and superoxide dismutase (SOD) were investigated. 46 HD and 16 CAPD patients were included in the study. 24 healthy individuals were taken as controls. When compared with the HD group, plasma MDA levels were found to be significantly lower (p<0.05) and erythrocyte GPx and SOD levels were significantly higher (p<0.05, p<0.05) in the CAPD group. The MDA values of the both groups were significantly higher (p<0.0005, p<0.0005) while their GPx and SOD values were significantly lower (p<0.0005, p<0.0005, p<0.0005, p<0.0005) in respect to the control. It was concluded that when the parameters of oxidant and antioxidant systems were investigated both dialysis applications significantly increased oxidative stress. However, peritoneal dialysis caused oxidative stress in lesser extend.
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Abstract (Original Language): 
Kronik böbrek yetmezliği komplikasy onlar inin gelişiminde serbest oksijen radikal düzeyi artışının önemi bilinmektedir. Oksidasyon ürünlerinin artışından yapım fazlalığı veya antioksidan sistemlerin yetersizliği sorumludur. Diyaliz uygulamalarında oksidatif stresler artmıştır. Bu çalışmada, lipid peroksidasyonu göstergesi olarak plazma malondialdehit (MDA) ve antioksidan enzimlerden eritrosit glutatyon peroksidaz (GPx) ve süperoksit dismutaz (SOD) düzeyleri üzerine hemodiyaliz (HD) ve ayaktan sürekli periton diyalizi (SAPD) 'nin etkilerini araştırmak amaçlandı. Çalışmaya 46 hemodiyaliz 16 periton diyalizi hastası ile kontrol grubu olarak 24 sağlıklı birey alındı. SAPD grubunda plazma MDA değerleri HD grubuna göre anlamlı olarak düşük (p<0.05), eritrosit GPx ve SOD değerleri anlamlı olarak yüksek bulundu (p<0.05, p<0.05). Kontrol grubuna göre her iki hasta grubunun MDA değerleri anlamlı olarak fazla iken (p<0.0005, p<0.0005) GPx (p<0.0005, p<0.0005) ve SOD değerleri düşük bulundu (p<0.0005, p<0.0005). Çalışma sonucunda incelenen parametrelere göre her iki diyaliz uygulamasının kontrol grubuna göre belirgin olarak oksidatif stresi arttırdığı, SAPD'nin HD'ye göre daha az oksidatif stres oluşturduğu saptandı.
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  • 2
88-92
  • Turkish

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