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ADRENOMEDULLİN: YENİ BİR RENAL DÜZENLEYİCİ PEPTİD

ADRENOMEDULLIN A NEW RENAL REGULATINPEPTIDE

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Adrenomedullin (ADM), a novel peptide recently isolatedfrompheochromocytoma, elicitingvasorelaxing activity, is the strongest among all known peptides. ADM mRNA has been detected in the adrenal medulla, cardiac tissue, lung, and kidney. İmmunohistochemical studies have demonstrated the localization of ADM in glomeruli, tubules, and collecting cells of the kidney. ADM has diuretic and natriuretic actions, which are mediated by increases in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. Clinically, plasma ADM and urinary levels are altered in patients with different renal disease. Further investigations are required to address the importance of ADM under various conditions.
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Abstract (Original Language): 
Yakın zamanlarda feokromositomadan izole edilen adrenomedullin (ADM) bilinenpeptidler arasında en güçlü damar genişletici etkinliğe sahiptir. ADM mRNA 'sı adrenal medulla, kalp, akciğerler ve böbreklerde saptanmıştır. İmmunhistokimyasal çalışmalarda ADM böbreğin glomerüllerinde, tübüllerinde ve toplayıcı sistemde gösterilmiştir. Diüretik ve natriüretik etkileri olan bupeptid, etkileriniglomerüler filtrasyonu artırıp, tubuler sodyum geri emilimini azaltarak yapmaktadır. Klinik çalışmalarda, plazma ve idrar ADM düzeylerinin farklı böbrek hastalıklarında değiştiği gösterilmiştir. Dolayısıyla ADM'nin çeşitli klinik durumlardaki önemini ortaya koyacak araştırmalara gereksinim vardır.
FULL TEXT (PDF): 
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  • 4
198-201
  • Turkish

REFERENCES

References: 

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