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KRONİK HEMODİYALİZ HASTALARINDA PARATHORMONUN SOL VENTRİKÜL HİPERTROFİSİ ÜZERİNE ETKİSİ

THE EFFECT OF PARATHORMONE ON LEFT VENTRICULAR HYPERTROPHY IN CHRONIC HEMODIALYSIS PATIENT

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2003

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Keywords (Original Language):

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Abstract (2. Language): 
Secondary hyperparathyroidism, high phosphate (PO4) and calciumphospltateproduct (CaxP04 is highly prevalent among patients with end stage renal disease (ESRD) and is associated with increased cardiac mortality risk in hemodialysis (HD) patients. To evaluate the response of intact parathyroid hormone (iPTH) on left ventricular hypertrophy in hemodialysis patients with secondary hyperparathroidism we perform echocardiography assessments of iPTHlevel high 20 and normal 20 chronic HDpatient. Left ventricular mass index (SVKI) and relative wall thickness (RDK) values are indicators of left ventricular hyperthrophy (SVH). These values also indicated left ventricular hiperthrophy in both of the two groups, however they were more significant in the group with high iPTH levels compared to the group with normal iPTH levels (p<0,001). This study has shown that high iPTH levels contribute to left ventricular hypertrophy. Consequently, we think that in HD patients keeping high iPTH levels in control have a key importance regarding SVH.
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Abstract (Original Language): 
Sekonder hiperparatirodizm, yüksek fosfat (PO4) ve kalsiyum ile fosfat çarpımı (CaxP04) son dönem böbrek yetmezliği (SDBY) olanlar arasında büyük ölçüde yaygın olup, hemodiyaliz (HD) hastalarında kardiyak komplikasyonlara bağlı artan ölüm oranı riskini de beraberinde getirir. İntakt parathormonun (iPTH) sekonder hiperparatiroidizmi olan HD hastalarında sol ventrikül hipertrofisi üzerine etkisini ekokardiyografi ile değerlendirmek üzere İPTH seviyesi yüksek 20 ve normal olan 20 kronik HD hastasını çalışmaya aldık. Sol ventrikül kitle indeksi (SVKİ) ve relatif duvar kalınlığı (RDK) sol ventrikül hipertrofısini (SVH) gösteren indikatörlerdir. Bu değerler her iki grupta da sol ventrikül hipertrofısini göstermekle birlikte, karşılaştırıldığında İPTH düzeyi yüksek grupta İPTH düzeyi normal olan gruba göre anlamlı olarak yüksekti (p<0,001). Bu çalışma yüksek İPTH düzeyinin sol ventrikül hipertrofisine katkıda bulunduğunu göstermektedir. Yüksek İPTH düzeyinin HD hastalarında kontrol altına alınmasının SVH' de kilit rol oynayabileceğini düşünmekteyiz.
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  • 1
34-37
  • Turkish

REFERENCES

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