Buradasınız

Anasayfa » Content

Hemodiyaliz Hastalarında Depresyon Serum Lipid Düzeyleri ile İlişkili mi?

Are Serum Lipid Levels Associated With Depression in Hemodialysis Patients?

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Background: Recent study suggested a relation between low levels of serum lipids and depression. The aim of this study was to as¬ sess the association between serum lipid levels and depression in patients with end-stage renal disease (ESRD). Methods: All the patients who were attending Yüzüncü Yil University Faculty of Medicine Training Hospital Hemodialysis Unit, in Turkey, from August 2000 to July 2001, were prospectively studied. Serum TC, LDL-c, HDL-c, VLDL-c and triglyceride levels were measured and Beck Depression Inventory (BDI) was administered to all patients. Diabetic patients were excluded. Results: There were 46 patients (25 males and 21 females). Me¬ an duration of hemodialysis was 28.1 ± 30.2 months. Mean Kt/V was 1.2 ± 0.4. The mean age of study group was 45.2 ± 16.3 years and the age range was 15-73 years. Mean serum albumin concentration was 3.63 ± 0.55 (2.5-4.7) g/dL. The patients' mean BDI was 15.9 ± 6.2 (4¬ 31). There was association between serum TC (total cholesterol), LDL-c (low density lipoprotein cholesterol), HDL-c (high density lipoprotein cholesterol) and depression but no association between serum VLDL-c (very-low density lipoprotein cholesterol) and triglyceride levels and depression in patients with ESRD. Conclusion: Depression is the most common psychological fin¬ ding in patients with ESRD. Our study demonstrate that there were associations between low serum TC, LDL-c, HDL-c levels and depres¬ sion but there was no association between depression and serum triglyceride and VLDL-c levels in patients with ESRD.
Bookmark/Search this post with
Abstract (Original Language): 
Amaç: Yakın zamanda yapılan bazı çalışmalarda serum lipid düzeyleri ile depresyon arasında ilişki saptanmıştır. Çalışmamızda he¬ modiyalize giren hastalarda serum lipid düzeyleri ile depresyon ara¬ sındaki ilişkiyi araştırmayı amaçladık. Yöntem ve gereçler: Çalışmaya Yüzüncü Yıl Üniversitesi Tıp Fakültesi Eğitim Hastanesi Hemodiyaliz Ünitesi'nde Ağustos 2000-Haziran 2001 arasında hemodiyalize giren hastalar dahil edildi. Hemodiyaliz hastalarında serum total kolesterol, yüksek yoğunluklu kolesterol (HDL), düşük yoğunluklu kolesterol (LDL), trigliserid ve çok düşük yoğunluklu kolesterol (VLDL) düzeyleri ile depresyon arasında ilişki araştırıldı. Depresyon düzeyi Beck Depresyon indeksi (BDİ) ile ölçüldü. Diyabetik hastalar çalışma dışı bırakıldı. Bulgular: Çalışmaya 25'i erkek, 21'i kadın, yaş ortalaması 45.2 ± 16.3 (15-73 yaş) yıl olan 46 hasta dahil edildi. Ortalama hemodiyaliz süresi 28 ± 30.2 ay idi. Ortalama Kt/V 1.2 ± 0.4 idi. Ortalama serum albümin değeri 3.63 ± 0.55 (2.5-4.7) g/dL, ortalama BDİ 15.9 ± 6.2 (4¬ 31) idi. Serum TK, LDL ve HDL ile depresyon arasında ilişki saptanırken (sırasıyla p değeri ve Pearson korelasyon katsayısı 0.002, 0.006, 0.563; -0.439, -0.403, -0.087 idi.); TG ve VLDL düzeyleri ile depresyon arasında saptanmadı (p değeri 0.096 ve 0.091, korelasyon katsayısı - 0.249 ve -0.252 idi). Sonuç: Depresyon, hemodiyaliz hastalarında en sık görülen psikolojik bulgudur. Çalışmamızda serum TK, HDL, LDL düzeyleri ile depresyon arasında zıt yönlü bir ilişki varken, TG ve VLDL düzeyleri ile depresyon arasında ilişki saptanmadı.
FULL TEXT (PDF): 
PDF icon pdf_tndt_612.pdf
  • 2
106-110
  • Turkish

REFERENCES

References: 

1. Finkelstein FO, Finkelstein FH. Depression in chronic dialysis patients: assessment and treatment. Nephrol Dial Transplant 2000;15:1911-3.
2. Smith MD, Hong BA, Robson AM. Diagnosis of depression in patients with end stage renal disease. Comparative dialysis. Am J Med 1985;79:160-6.
3. Ruberman W, Weinblatt E, Goldberg JD, Chaudhary BS. Psychosocial influences on mortality after myocardial in¬farction. N Eng J Med 1984;311:552-9.
4. Covinsky KE, Kahana E, Chin MH, Palmer RM, Fortinsky RH, Landefield CS. Depressive symptoms and 3-year mor¬tality in older hospitalized patients. Ann Intern Med
1999;130:563-9.
5. Kimmel PL, Weihs KL, Peterson RA. Survival in hemodi-alysis patients: the role of depression. J Am Soc Nephrol
1993;4:12-27.
6. Alabowska SB, Todorova BB, Labudovic DD, Tosheska KN. LDL and HDL subclass distribution in patients with end-stage renal disease. Clin Biochemistr 2002;35:211-6.
7. Bajwa WA, Asnis Sanderson WC, Irfan A, van-Prag HM. High cholesterol levels in patiens with panic disorder. Am J Psychiatry 1992;149:376-8.
8. Glueck CJ, Tieger M, Kunkel R, Hammer T, Tracy T, Spi¬ers J. Hypercholesterolemia and affective disorders. Am J
Med Sci 1994;308:218-25.
9. Brown SL, Salive ME, Harris TB, Simonsick EM, Guarlnick JM, Kohout FJ. Low cholesterol concentrations and seve¬re depressive symptoms in elderly people. Br Med J
1994;308:1328-32.
10. Su KP, Tsai SY. Cholesterol, depression and suicide. Br J
Psychiatr 2000;176:399-400.
11. Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.
Clin Chem 1972;18:499-502.
12. Beck AT, Steer RA, Garbin MG. Psychometric properties of the Beck Depression Inventory: Twenty-five years of
evaluation. Clin Psychol Rev 1988;8:77-100.
13. Kimmel PL, Peterson RA, Weihs KL, et al. Behavioral compliance with dialysis prescription in hemodialysis pa¬tients. J Am Soc Nephrol 1995;5:1826-34.
14. Kimmel PL, Peterson RA, Weihs KL, et al. Multiple measu¬rements of depression predict mortality in a longitudinal study of chronic hemodialysis patients. Kidney Int
2000:57:2093-8.
15. Kimmel PL. Psychosocial factors in adult end-stage renal disease patients treated with hemodialysis: correlates and
outcomes. Am J Kidney Dis 2000;35:132-40.
16. Muldoon MF, Manuck SB, Matthews KA. Lowering choles-
Official Journal of the Turkish Society of Nephrology / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi
109
0 Are Serum Lipid Levels Associated With Depression in Hemodialysis Patients?
terol concentrations and mortality: a quantitative review of primary prevention trials. Br Med J 1990:310;309-14.
17. Ploeckinger B, Dantendorfer K, Ulm M, et al. Rapid dec¬rease of serum cholesterol concentration and postpartum depression. Br Med J 1996;313:664.
18. Engelberg H. Low serum cholesterol and suicide. The
Lancet 1992;339:727-9.
19. Garland M, Corvin A, Golden J, Fitzpatrick P, Cunning¬ham S, Walsh N. Total serum cholesterol in relation to psychological correlates in parasuicide. Br Med J
2000;177:77-83.
20. Virkkunen M. Serum cholesterol levels in homicidal of¬fenders. Neuropsychobiology 1983;10:65-9 (Abstract).
21. Partonen T, Haukka J, Virtamo J, et al. Association of low serum total cholesterol with major depression and suici¬de. Br Med J 1999;175;259-62.
22. Rafter D. Biochemical markers of anxiety and depression.
Psychiatry Res 2001;103:93-6.
23. Rabe-Jablonska J, Poprawska I. Levels of serum total cho¬lesterol and LDL-cholesterol in patients with major dep¬ression in acute period and remission. Med Sci Monit 2000;6:539-47.
24. Coutu MF, Dupuis G, D'Antono B. The impact of cholesterol lowering on patients' mood. J Behav Med
2001;24:517-36.
25. Sevincok L, Buyukozturk A, Dereboy F. Serum lipid con¬centrations in patients with comorbid generalized anxiety disorder and major depressive disorder. Can J Psychiatry
2001;46:68-71.
26. Chen CC, Lu FH, Wu JS, Chang CJ. Correlation between serum lipid concentrations and psychological distress.
Psychiatry Res 2001;102:153-62.

Thank you for copying data from http://www.arastirmax.com