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Erkek Hemodiyaliz Hastalarında Serum Çinko Seviyesi, Hormonal Profil ve Seksüel Disfonksiyon Arasındaki İlişki

Relationship Between Serum Zinc Levels, Hormonal Profiles and Sexual Dysfunctions in Male Hemodialysis Patients

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Abstract (2. Language): 
Objectives: To investigate the frequency of sexual disorders and the relationship between serum zinc levels, hormonal profiles and sexual dysfunctions in male HD patients. Materials and Methods: Forty-one male patients who were on chronic HD programme for at least six months, and treated by con¬ ventional bicarbonated HD 15 hours/week were evaluated. The se¬ rum levels of PRL, FSH, LH, progesterone, testosteron, TSH, free thyroxine and zinc were measured. A personal questionnaire was used to evaluate the sexual dysfunctions. Results: Three of the 41 patients had low serum zinc levels. Thirty-three (80.5%) of patients had elevated PRL levels. 17 (41.5%) of the patients had premature ejaculation, 10 (24.4%) had erectile dysfunction, 7 (17%) had impotence, and 7(17%) had decreased libi¬ do. A positive correlation was found between age and impotence (r=0.594, p=0.000) and between hypozincemia and premature ejacu¬ lation (r=0.334, p=0.033). A negative correlation was found between HD duration and PRL levels (r=-0.363, p=0.020). There was not any significant correlation between hypozincemia and hyperprolactinemia (r=0.084, p=0.456). Conclusion: Hypozincemia and hyperprolactinemia were prevalant among HD patients. No correlation was found between hypozincemia and hyperprolactinemia. PRL levels decreased due to HD du¬ ration. A correlation was found between serum Zn levels and prema¬ ture ejaculation.
Abstract (Original Language): 
Amaç: Erkek hemodiyaliz hastalarında seksüel bozuklukların sıklığı ile serum çinko seviyesi, hormonal profil ve seksüel disfonksiyon arasındaki ilişkinin değerlendirilmesi. Materyal ve Metot: En az altı aydır haftada 15 saat konvansiyonel bikarbonat tedavisi gören 41 erkek hasta değerlendirildi. Serum PRL, FSH, LH, progesteron, testosteron, TSH, serbest T4 ve çinko düzeyleri ölçüldü. Seksüel disfonksiyon kişisel anketle değerlendirildi. Bulgular: Üç hastada düşük serum çinko düzeyi tespit edildi. 33 (%80.5) hastada PRL yüksekti. Hastaların 17'sinde (%41.5) prematür ejakülasyon, 10'unda (%24.4) erektil disfonksiyon, 7'sinde (%17) impotans ve 7'sinde (%17) azalmış libido saptandı. Yaş ile impotans arasında (r=0.594, p=0.000) ve hipozinkemi ile prematür ejakülasyon arasında (r=0.334, p=0.033) pozitif korelasyon bulundu. Hemodiyaliz süresi ile PRL düzeyi arasında negatif bir korelasyon saptandı (r=-0.363, p=0.020). Hipozinkemi ile hiperproloktinemi arasında anlamlı korelasyon bulunmadı (r=0.084, p=0.456). Sonuç: Hipozinkemi ve hiperprolaktinemi hemodiyaliz hastalarında yaygındır. Hipozinkemi ile hiperprolaktinemi arasında ilişki bu¬ lunmadı. PRL düzeyi, hemodiyaliz süresine bağlı azalmış bulundu. Serum çinko düzeyi ile prematür ejakülasyon arasında pozitif korelasyon saptandı.
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