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Lityumla İlişkili Nefrotik Sendrom Olgusu

Lithium Induced Nephrotic Syndrome

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Abstract (2. Language): 
Lithium carbonate is an effective, commonly used treatment for manic-depressive illness. The drug is known to produce a number of renal side effects, including impaired urinary acidification, polyuria, and impaired renal concentrating ability, which have been summarized elsewhere. Lithium is a rare cause of nephrotic syndrome, a complication that reduces renal lithium excretion and precipitates lithium toxicity. We describe here a case in which the clinical features of lithium toxicity appeared with nephrotic syndrome, due to focal segmental glomerulosclerosis, developed in a patient treated with lithium. We report the case of a 20-year-old woman with bipolar affective disorder
Abstract (Original Language): 
Lityum karbonat manik-depresif hastalıkta kullanılan etkili bir ilaçtır, ilacın, böbreğin konsantrasyon yeteneğinde bozulma, poliüri, üriner asidifikasyon yeteneğinde bozulma, interstisyel nefrit gibi birtakım renal yan etkileri bilinmektedir. Lityum tedavisi ile ilişkili nefrotik sendrom tablosu nadir görülen bir klinik tablodur. Bu yan etki, lityum atılımının azalmasına bağlı lityum toksisitesine de neden olabilir. Burada, lityum kullanımı sonucu fokal segmental glomerüloskleroza bağlı nefrotik sendrom ve lityum toksisitesinin görüldüğü 20 yaşında bir kadın hasta sunulacaktır.
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REFERENCES

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