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Meme Kanseri Hastalarında Kemoterapinin Böbrek Fonksiyonlarına Etkisi

Effect of Chemotherapy on Renal Function Tests of Breast Cancer Patients

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
We aimed to find out the renal function alteration with | respect to adjuvant chemotherapy administration in early breast i cancer patients. Methods: Forty women with diagnosis of infiltrai tive ductal carcinoma involved into the study. The data of serum | creatinine levels and glomerular filtration rate were collected | before chemotherapy and after completing all cycles of different \ treatment regimens (adriamycin + cyclophosphamide, or | cyclophosphamide 4 epirubicin, or cyclophosphamide + I methotrexate + 5-fluorouracil, or 5-fluorouracil + epirubicin + j cyclophosphamide). Results: The mean creatinine levels of our 40 ; breast cancer patients were 0.69 ± 0.16, and 0.68 ± 0.14 mg/dL I before and after chemotherapy respectively. Mean glomerular fil- I tration rate of our patients were 99 mL/min/1.73 m2 and 100 I mL/min/1.73 m2 before chemotherapy and after chemotherapy l respectively (p>0.05). Conclusion: The adjuvant chemotherapeutic j agents were found not to have any clinically evident nephrotoxic j effects. No difference was noticed between chemotherapy regi- ; mens with respect to creatinine levels and glomerular filtration i rate.
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Abstract (Original Language): 
we Amaç: Erken meme kanseri olan hastalarda adjuvan kemoterapi ile böbrek fonksiyonlarında^ değişiklikler araştırıldı. Yöntem: Infiltratif duktal karsinomu olan 40 kadın hasta çalışmaya alındı. Kemoterapi (adriamisin + siklofosfamid, veya siklofosfamid + epirubisin veya siklofosfamid + metotreksat + 5-florourasil veya 5-florourasil + epirubisin + siklofosfamid) öncesi ve sonrası serum kreatinin düzeyleri ve MDRD formülü ile hesaplanan glomerül filtrasyon değerleri saptandı. Sonuçlar: Tüm hastaların kemoterapi öncesi ortalama serum kreatinin düzeyi 0.69 ± 0.16 ve kemoterapi sonrası ortalama serum kreatinin düzeyi 0.68 ± 0.14 mg/dL olarak saptandı. Hastaların, kemoterapi öncesi ortalama glomerül filtrasyon değeri 99 mL/dk/1.73 m2 ve kemoterapi sonrası ortalama glomerül filtrasyon değeri 100 mL/dk/1.73 m2 olarak bulundu (p>0.05). Tartışma: Sonuç olarak, infiltratif duktal karsinomu olan hastalarda adjuvan kemoterapötik ajanların klinik olarak belirgin nefrotoksik etkilerinin olmadığı belirlendi. Kemoterapötik rejimler arasında serum kreatinin ve glomerül filtrasyon değerleri açısından bir fark saptanmadı.
FULL TEXT (PDF): 
PDF icon arastrmx_172977_16_pp_187-189.pdf
  • 4
187-189
  • Turkish

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