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Renal Transplantasyon Uygulanan Hastalarda İmmünsupresif Tedavinin Monitorizasyonu

Monitorization of Immunosuppressive Therapy in Renal Transplant Recipients

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Abstract (2. Language): 
Despite improved short-term outcome in patient and graft survival in renal transplantation, no major improvements have been detected in long-term survival. The success of solid organ transplantation lies in the administering an adequate dosage of an agent while at the same time avoiding toxicity related to excessive immunosuppression or concentrationrelated secondary toxicities to a large degree. Therapeutic drug monitoring would make it possible to define the therapeutic and toxic dosage ranges. We herein present an article concerning therapeutic drug monitorization of immunosuppressive drugs that are currently used in renal transplantation.
Abstract (Original Language): 
Renal transplantasyonda kısa vadede hasta ve greft sonuçlarındaki kabul edilebilir gelişmelere rağmen, uzun süreli takip sonuçlarında doyurucu bir gelişme mevcut değildir. Renal transplant hastalarında uzun dönem sonuçlarını iyileştirmek adına yapılması gereken önemli girişimlerden biri de uygulanan immünsupressif tedavide yeterli immünsupresyon ile ilaç toksisitesi arasındaki dengeyi sağlamaktır. İmmünsupressif tedavinin monitorizasyonu ile tedavi edici ve toksik dozajlar belirlenebilir ve gerekli hedeflere ulaşılabilir. Bu yazıda, renal transplantasyon sırasında kullanılan ve monitorizasyonu yapılan ilaçlarla ilişkili güncel bilgilere yer verilmektedir.
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