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Hepatit C Enfeksiyonu ve Diyaliz: Genel bir Bakış

Hepatitis C and Infection Dialysis: A General Overwiew

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Abstract (2. Language): 
More than 170 million people are thought to be infected by the hepatitis C virus globally and nearly one million of these patients were die due to cirhhosis and hepatocelular carcinoma every year. Hepatitis C infection is highly prevalent in dialysis patients. Hepatits C infection harms the kidneys by various immunological and non-immunological mechanisms. The prresence of hepatitis C is closely related to increased mortality in dialysis patients. Recent studies have disclosed that hepatitis C infection is also associated with impaired life quality in dialysis patients. The most important problem of hepatitis C infection today is the lack of efficiency and reliability of the drugs used to treat hepatitis C infection in dialysis patients. Large, randomized well-designed studies on the treatment of hepatitis C infection in dialysis patients are still lacking. In the current review, we tried to provide general information about hepatitis C infection in dialysis patients based on the current literature
Abstract (Original Language): 
Günümüzdeki verilere göre dünya çapında yaklaşık olarak 170 milyondan fazla insanın hepatit C virüsü ile enfekte olduğu düşünülmektedir ve yılda yaklaşık bir milyon kişi hepatit C enfeksiyonuna bağlı siroz ve/veya karaciğer kanseri nedeni ile yaşamını yitirmektedir. Diyaliz hastalarında da hepatit C enfeksiyonu çok yaygındır. Hepatit C enfeksiyonu immünolojik olan ve olmayan birçok mekanizmayı tetikleyerek böbreğe zarar verir. Diyaliz hastalarında hepatit C enfeksiyonunun bulunması mortalite ile yakından ilgilidir. Ayrıca diyaliz hastalarında hepatit C enfeksiyonunun kötü yaşam kalitesiyle ilişkili olabileceği gösterilmiştir. Günümüzde en önemli sorunlardan biri, hepatit C enfeksiyonunun tedavisi için kullanılan ilaçların etkinliğinin ve güvenilirliliğinin diyaliz hastalarında tam olarak anlaşılamamış olmasıdır. Bu konulara ilişkin büyük çaplı çalışmalar özellikle diyaliz hastalarında hala eksiktir. Biz bu derlememizde literatürdeki son verilere dayanarak diyaliz hastalarında hepatit C enfeksiyonu hakkında genel bilgi vermeyi amaçladık.
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