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Renin Anjiyotensin Sistemi İnhibisyonu Enkapsüle Periton Sklerozu Gelişmesini Engelleyebilir

Renin Angiotensin System Inhibition may Prevent Progression of Encapsulated Peritoneal Sclerosis

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2009

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Encapsulated Peritoneal Sclerosis (EPS) is a devastating complication of long-term peritoneal dialysis (PD) patients. Angiotensin-2 is a well-known agent that promotes fibrosis and inflammation in the course of various inflammatory diseases. We aimed to investigate the effects of enalapril (ENA), valsartan (VAL) and ENA plus VAL (COMB) on the progression (P) of EPS induced by chlorhexidine gluconate (CG). Forty-two non-uremic wistar albino rats were divided into five groups: Control group: 2 ml isotonic saline intraperitoneally (IP) daily, CG group: IP 2 ml/200 g injection of CG (0.1%) and ethanol (15%) dissolved in saline; All treatment groups received CG solution plus the following: ENA-P group: 100 mg/L ENA, VAL-P group: 640 mg/L VAL, COMB-P group: 100 mg/L ENA + 640 mg/L VAL, given daily for 3 weeks in drinking water. ENA and VAL have beneficial effects on peritoneal functional and morphological alterations induced by CG via inhibition of neoangiogenesis, increased UF volume and decreased peritoneal thickness and dialysate cell count. Dual blockage of renin angiotensin system (RAS) has no additional benefits except improved peritoneal thickness.
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Abstract (Original Language): 
Enkapsüle Periton Sklerozu (EPS), sürekli ayaktan periton diyalizi (PD) hastalarında ortaya çıkabilen ağır bir komplikasyondur. Altta yatan patofizyoloji yeni damar oluşumu, fibrozis ve inflamasyondur. Anjiyotensin II birçok hastalığın seyrinde inflamasyon ve fibrozis gelişimine katkıda bulunur. Bu çalışmanın amacı, renin anjiyotensin sistemi inhibisyonunun EPS progresyonu üzerine etkisini araştırmaktır. Kırk iki üremik olmayan wistar albino sıçan, beş gruba ayrıldı. Kontrol grubu (n:10): Periton içine (İP) 2 ml izotonik, Klorheksidin glukonat (CG) grubu (n:10): İP %0,1 CG ve %15 etanol verildi. Tüm tedavi grubu sıçanlara CG solüsyonu ile birlikte Enalapril-Progresyon grubunda (ENA-P) (n:8): 100 mg/L enalapril, Valsartan-Progresyon grubunda (VAL-P) (n=7): 640 mg/L valsartan ve Kombinasyon-Progresyon grubunda (KOMB-P) (n=7): 100 mg/L enalapril + 640 mg/L valsartan 3 hafta boyunca her gün içme sularına katılarak verildi. Enalapril ve Valsartan; yeni damar oluşumunu engellemek, UF volümünü arttırmak, periton kalınlığını ve diyalizat hücre sayısını azaltmak suretiyle, CG’ nin neden olduğu morfolojik değişiklikler ve bozulmuş periton fonksiyonları üzerine olumlu etkiler göstermiştir. RAS’ın ikili inhibisyonu periton kalınlığı hariç ek fayda sağlamamıştır. Sonuç olarak, EPS progresyonunu önlemede, RAS blokajı; membran bütünlüğünü korumak suretiyle yeni bir tedavi seçeneği olabilir.
FULL TEXT (PDF): 
PDF icon arastrmx_172977_18_pp_112-116.pdf
  • 3
112-116
  • Turkish

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HÜR E ve ark: Renin Anjiyotensin Sistemi İnhibisyonu
Enkapsüle Periton Sklerozu Gelişmesini Engelleyebilir
Cilt/Vol. 18, No, 3, 2009 Sayfa/Page 112-116
Türk Nefroloji Diyaliz ve Transplantasyon Dergisi
Turkish Nephrology, Dialysis and Transplantation Journal
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