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Renal Hastamda Artmış bir N-terminal Pro-beyin Natriüretik Peptidi (NT-Pro-BNP) ne Anlama Gelir?

What does an Elevated N-terminal Pro-brain Natriuretic Peptide (NT-pro-BNP) Mean in my Renal Patient?

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DOI: 
doi: 10.5262/tndt.2010.1002.01
Abstract (2. Language): 
The N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is released in response to volume expansion and/or increased tension on cardiac ventricular myocytes. In non-uremic patients, NT-pro-BNP is a useful diagnostic and prognostic biomarker for diagnosis and risk assessment of patients with heart failure. However, impaired kidney function is associated with elevated circulating levels of NT-pro- BNP. The present review summarizes the literature on NT-pro-BNP in kidney disease, both acute and chronic. We attempt to highlight the importance of estimating kidney function before interpreting an elevated NT-pro-BNP measurement. We also suggest that NT-pro-BNP is not a reliable marker of heart failure in the acute setting, but that longitudinal changes may be of value when tracking volume status in this patient group.
Abstract (Original Language): 
N-terminal pro-beyin natriüretik peptidi (NT-pro-BNP) kardiyak ventriküler miyositlerde artmış gerilim ve/veya hacim artmasına cevaben salınır. Üremik olmayan hastalarda NT-pro-BNP kalp yetmezlikli hastaların tanısı ve risk değerlendirmesi için faydalı bir tanısal ve prognostik biyomarkerdir. Ancak, bozulmuş böbrek fonksiyonu artmış dolaşan NT-pro-BNP düzeyleriyle ilişkilidir. Bu derleme hem akut hem kronik böbrek hastalığında NT-pro-BNP ile ilişkili literatürü özetlemektedir. Yükselmiş bir NTpro- BNP ölçümünü yorumlamadan önce böbrek fonksiyonunu tahmin etmenin önemini vurgulamaya çalışıyoruz. Ayrıca NT-pro-BNP’nin akut durumda kalp yetmezliğinin güvenilir bir markeri olmadığını ama bu hasta grubunda hacim durumunu izlerken longitudinal değişikliklerin önemi olabileceğini belirtiyoruz.
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