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Böbrek Nakli Sonrası Tekrarlayan Glomerülonefritler

Recurrent Glomerulonephritis after Renal Transplantation

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DOI: 
DOI 10.5262/tndt.2010.1003.16

Keywords (Original Language):

Abstract (2. Language): 
The most frequent cause of recurrent disease after renal transplantation is recurrent glomerulonephritis. The risk factors for recurrence of glomerulonephritis are largely unknown or imprecise and prediction remains difficult. Among the recurrent glomerulonephritides, type II membranoproliferative glomerulonephritis, immunoglobulin A nephropathy, and focal and segmental glomerulosclerosis have the highest rates of recurrence. Recurrent disease usually presents with similar manifestations as the native disease. With regard to treatment of recurrent glomerular disease in the renal allograft, plasma exchange may be effective in reducing proteinuria in patients with early recurrence of focal and segmental glomerulosclerosis, but immunosuppressive therapy is generally ineffective in the prevention or treatment of recurrent disease. General supportive measures including strict blood pressure control and inhibition or blockade of the renin-angiotensin pathway are helpful in retarding the rate of deterioration in renal allograft function. Despite the risk of recurrence, kidney transplantation following primary glomerulonephritides enjoys graft and patient survival rates comparable to other causes of end-stage renal failure. With a few exceptions, living related renal transplantation is not contraindicated in view of the favorable outcome and the donor shortage. In this mini review we tried to discuss commonly encountered recurrent glomerulonephritides after renal transplantation
Abstract (Original Language): 
Böbrek nakli sonrası en sık tekrarlayan hastalık grubu glomerülonefritlerdir. Bununla birlikte nakil sonrasında primer glomerüler hastalıkların nüks etmesine ilişkin risk faktörleri tam olarak aydınlatılamamıştır. Tip 2 membranoproliferatif glomerülonefrit, IgA nefropatisi, fokal segmental glomerülonefrit, böbrek nakli sonrasında en sık tekrarlayan glomerülonefritler olarak sıralanabilir. Nakil sonrası tekrarlayan glomerülonefritler, klinik olarak genellikle orijinal hastalılıklara benzer bulgular gösterir. Tekrarlayan glomerülonefritlerin tedavisinde immünosupresif tedavi rejimleri genellikle pek etkili olmamaktadır. Bazı tekrarlayan fokal segmental glomerülonefritlerde, erken dönemde plazma değişiminin proteinuriyi azalttığı gösterilmiştir. Kan basıncının sıkı kontrolü, renin anjiotensinojen aldosteron sisteminin baskılanması gibi genel önlemlerin renal allogreft fonksiyonundaki bozulmayı geciktirdiği bilinmektedir. Genel olarak bakıldığında, nakil sonrası tekrarlayan glomerülonefritlerin greft ve hasta sağkalım oranları çok kötü değildir. Glomerülonefriti olan hastalarda birkaç istisna dışında böbrek naklinin sonuçları yüz güldürücüdür. Biz bu derlememizde nakil sonrası tekrarlayan glomerülonefritler hakkında genel bir bilgi vermeyi amaçladık.
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REFERENCES

References: 

1. Briganti EM, Russ GR, McNeil JJ, Atkins RC, Chadban SJ: Risk
of renal allograft loss from recurrent glomerulonephritis. N Engl J
Med 2002; 347:103-109
2. Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ,
Stablein D: Improved graft survival after renal transplantation in the
United States, 1988 to 1996. N Engl J Med 2000; 342:605-612
3. Mathew TH, Mathews DC, Hobbs JB, Kincaid-Smith P: Gbomerular
lesions after renal transplantation. Am J Med 1975; 59:177-190
4. Morzycka M, Croker BP, Seigler HF, Tisher CC: Evaluation of
recurrent gbomerubonephritis in kidney allografts. Am J Med 1982;
72:588-598
5. Hariharan S, Adams MB, Brennan DC, Davis CL, First MR, Johnson
CP, Ouseph R, Peddi VR, Pelz CJ, Roza AM, Vincenti F, George V:
Recurrent and de novo glomerular disease after renal transplantation:
A report from renal allograft disease registry. Transplantation 1999;
68:635-641
Cilt/Vol: 19, No: 3, 2010, Sayfa/Page: 151-156 155
Türk N efroloji D iyaliz ve Transplantasyon D ergisi Afşar B ve ark: Böbrek Nakli Sonrası Tekrarlayan Glomerülonefritler
Turkish Nephrology, Dialysis and Transplantation Journal
6. Briggs JD, Jones E: Recurrence of glomerulonephritis following
renal transplantation. Scientific Advisory Board of the ERA-EDTA
Registry. Nephrol Dial Transplant 1999; 14:564-565
7. Choy BY, Chan TM, Lai KN: Recurrent glomerulonephritis after
kidney transplantation. American Journal of Transplantation 2006;
6:2535-2542
8. Berger J, Noel LH, Nabarra B: Recurrence of mesangial IgA
nephropathy after renal transplantation. Contrib Nephrol 1984; 40:
195-197
9. Odum J, Peh CA, Clarkson AR, Bannister KM, Seymour AE, Gillis
D, Thomas AC, Mathew TH, Woodroffe AJ: Recurrent mesangial
IgA nephritis following renal transplantation. Nephrol Dial
Transplant 1994; 9:309-312
10. Lim EC, Chia D, Gjertson DW, Koka P, Terasaki PI: In vitro studies
to explain high renal allograft survival in IgA nephropathy patients.
Transplantation 1993; 55:996-999
11. Bachman U, Biava C, Amend W, Feduska N, Melzer J, Salvatierra
O: The clinical course of IgA-nephropathy and Henoch-Schonlein
purpura following renal transplantation. Transplantation 1986; 42:
511-515
12. Choy BY, Chan TM, Lo SK, Lo WK, Lai KN: Renal transplantation
in patients with primary immunoglobulin A nephropathy. Nephrol
Dial Transplant 2003; 18:2399-2404
13. Moriyama T, Nitta K, Suzuki K, Honda K, Horita S, Uchida K, Yumura
W, Tanabe K, Toma H, Nihei H, Yamaguchi Y: Latent IgA deposition
from donor kidney is the major risk factor for recurrent IgA nephropathy
in renal transplantation. Clin Transplant 2005; 19: 41-48
14. Kesser M, Hiesse C, Hestin D, Mayeux D, Boubenider K,
Charpentier B: Recurrence of immunoglobulin A nephropathy after
renal transplantation in the cyclosporine era. Am J Kidney Dis 1996;
28:99-104
15. Freese P, Svalander C, Norden G, Nyberg G: Clinical risk factors for
recurrence of IgA nephropathy. Clin Transplant 1999; 13:313- 317
16. Wang AY, Lai FM, Yu AW, Lam PK, Chow KM, Choi PC: Recurrent
IgA Nephropathy in renal transplant allografts. Am J Kidney Dis
2001; 38:588-596
17. Frohnert PP, Donadio JV, Velosa JA, Holley KE, Sterioff S: The
fate of renal transplants in patients with IgA nephropathy. Clin
Transplant 1997; 11:127-133
18. Bumgardner GL, Amend WC, Ascher WL, Vincenti FG: Single
centre long term results of renal transplantation for IgA nephropathy.
Transplantation 1998; 65 (8):1053-1060
19. Kim YS, Moon JI, Jeong HJ, Kim MS, Kim SI, Choi KH, Lee HY,
Han DS, Park K: Live donor renal allograft in endstage renal failure
patients from immunoglobulin A nephropathy. Transplantation
2001; 71:233-238
20. Ponticelli C, Traversi L, Feliciani A, Cesana BM, Banfi G,
Tarantino A: Kidney transplantation in patients with IgA mesangial
glomerulonephritis. Kidney Int 2001; 60:1948-1954
21. Schena FP, Cerullo G, Rossini M, Lanzilotta SG, D’Altri C,
Mano C: Increased risk of end-stage renal disease in familial IgA
nephropathy. J Am Soc Nephrol 2002; 13:453-460
22. Dittrich E, Schmaldienst S, Soleiman A, Hörl WH, Pohanka E:
Rapamycin-associated post-transplantation glomerulonephritis and
its remission after reintroduction of calcineurin-inhibitor therapy.
Transpl Int 2004; 17:215-220
23. Ibrahim H, Rogers T, Casingal V, Sturdevant M, Tan M, Humar A,
Gillingham K, Matas A: Graft loss from recurrent glomerulonephritis
is not increased with a rapid steroid discontinuation protocol.
Transplantation 2006; 81:214-219
24. Oka K, Imai E, Moriyama T, Akagi Y, Ando A, Hori M, Okuyama
A, Toki K, Kyo M, Kokado Y, Takahara S: A clinicopathological
study of IgA nephropathy in renal transplant recipients: Beneficial
effect of angiotensin-converting enzyme inhibitor. Nephrol Dial
Transplant 2000; 15:689-695
25. Calvino J, Lens XM, Romero R, Sanchez-Guisande D: Long-term
anti-proteinuric effect of Losartan in renal transplant recipients
treated for hypertension. Nephrol Dial Transplant 2000; 15:82- 86
26. Meulders Q, Pirson Y, Cosyns JP, Squifflet JP, van Ypersele de
Strihou C: Course of Henoch-Schonlein nephritis after renal
transplantation. Report on ten patients and review of the literature.
Transplantation 1994; 58:1179-1186
27. Canaud G, Zuber J, Sberro R, Royale V, Anglicheau D, Snanoudj
R, Gaha K, Thervet E, Lefrère F, Cavazzana-Calvo M, Noël LH,
Méjean A, Legendre Ch, Martinez F: Intensive and prolonged
treatment of focal and segmental glomerulosclerosis recurrence in
adult kidney transplant recipients: a pilot study. Am J Transplant
2009; 9:1081-1086
28. Schachter AD, Harmon WE: Single-center analysis of early
recurrence of nephrotic syndrome following renal transplantation in
children. Pediatr Transplant 2001; 5:406-409
29. Baum MA, Stablein DM, Panzarino VM, Tejani A, Harmon
WE, Alexander SR: Loss of living donor renal allograft survival
advantage in children with focal segmental glomerulosclerosis.
Kidney Int 2001; 59:328-333
30. Ponticelli C: Recurrence of focal segmental glomerular sclerosis
(FSGS) after renal transplantation. Nephrol Dial Transplant 2010;
25:25-31
31. Stephanian E, Matas AJ, Mauer SM, Chavers B, Nevins T, Kashtan
C, Sutherland DE, Gores P, Najarian JS: Recurrence of disease
in patients retransplanted for focal segmental glomerulosclerosis.
Transplantation 1992; 53:755-757
32. Cheigh JS, Mouradian J, Soliman M, Tapia L, Riggio RR, Stenzel
KH, Rubin AL: Focal segmental gbomerulosclerosis in renal
transplants.Am J Kidney Dis 1983; 2:449-455
33. Maizel SE, Sibley RK, Horstman JP, Kjellstrand CM, Simmons
RL: Incidence and significance of recurrent focal segmental
gbomerubosclerosis in renal albograft recipients. Transplantation
1981; 32:512-516
Afşar B ve ark: Böbrek Nakli Sonrası Tekrarlayan Glomerülonefritler
Cilt/Vol: 19, No: 3, 2010, Sayfa/Page: 151-156 156
Türk N efroloji D iyaliz ve Transplantasyon D ergisi
Turkish Nephrology, Dialysis and Transplantation Journal
34. Dall’Amico R, Ghiggeri G, Carraro M, Artero M, Ghio L, Zamorani
E, Zennaro C, Basile G, Montini G, Rivabella L, Cardillo M,
Scalamogna M, Ginevri F: Prediction and treatment of recurrent
focal segmental glomerulosclerosis after renal transplantation in
children. Am J Kidney Dis 1999; 34:1048-1055
35. Ohta T, Kawaguchi H, Hattori M, Komatsu Y, Akioka Y, Nagata M,
Shiraga H, Ito K, Takahashi K, Ishikawa N, Tanabe K, Yamaguchi
Y, Ota K: Effect of pre-and postoperative plasmapheresis on
posttransplant recurrence of focal segmental glomerulosclerosis in
children. Transplantation 2001; 71:628-633
36. Gohh RY, Yango AF, Morrissey PE, Monaco AP, Gautam A, Sharma
M, McCarthy ET, Savin VJ: Preemptive plasmapheresis and
recurrence of FSGS in high risk renal transplant recipients. Am J
Transplant 2005; 5:2907-2912
37. Pescovitz MD, Book BK, Sidner RA: Resolution of recurrent focal
segmental glomerulosclerosis proteinuria after rituximab treatment.
N Engl J Med 2006; 354:1961-1963
38. Morelon E, Kreis H: Sirolimus therapy without calcineurin
inhibitors: Necker Hospital 8-year experience. Transpl Proc 2003;
35:52S-57S
39. Höcker B, Knüppel T, Waldherr R, Schaefer F, Weber S, Tönshoff
B: Recurrence of proteinuria 10 years post-transplant in NPHS2-
associated focal segmental glomerulosclerosis after conversion from
cyclosporine A to sirolimus. Pediatr Nephrol 2006; 21:1476-1479
40. Tumlin JA, Miller D, Near M, Selvaraj S, Hennigar R, Guasch A: A
prospective, open-label trial of sirolimus in the treatment of focal segmental
glomerulosclerosis. Clin J Am Soc Nephrol 2006; 1:109-116
41. Daniel C, Ziswiler R, Frey B, Pfister M, Marti HP: Proinflammatory
effects in experimental mesangial proliferative glomerulonephritis
of the immunosuppressive agent SDZ RAD, a rapamycin derivative
Exp Nephrol 2000; 8:52-62
42. Andresdottir MB, Assmann KJ, Hoitsma AJ, Koene RA, Wetzels
JF: Recurrence of type I membranoproliferative glomerulonephritis
after renal transplantation: Analysis of the incidence, risk factors,
and impact on graft survival. Transplantation 1997; 63:1628-1633
43. Braun MC, Stablein DM, Hamiwka LA, Bell L, Bartosh SM, Strife
CF: Recurrence of membranoproliferative glomerulonephritis
type II in renal allografts: The North American Pediatric Renal
Transplant Cooperative Study experience. J Am Soc Nephrol
2005; 16:2225- 2233
44. Lorenz EC, Sethi S, Leung N, Dispenzieri A, Fervenza FC, Cosio FG:
Recurrent membranoproliferative glomerulonephritis after kidney
transplantation. Kidney Int. 2010 Feb 3.
45. Josephson MA, Spargo B, Hollandsworth D, Thistlethwaite JR:
The recurrence of recurrent membranous glomerulopathy in a renal
transplant recipient: Case report and literature review. Am J Kidney
Dis 1994; 24:873-878
46. Cosyns JP, Couchoud C, Pouteil-Noble C, Squifflet JP, Pirson Y:
Recurrence of membranous nephropathy after renal transplantation:
Probability, outcome and risk factors. Clin Nephrol 1998; 50:144-153
47. Nachman PH, Segelmark M, Westman K, Hogan SL, Satterly KK,
Jennette JC, Falk R: Recurrent ANCA associated small vessel
vasculitis after transplantation: A pooled analysis. Kidney Int 1999;
56:1544-1550
48. Rosenstein ED, Ribot S, Ventresca E, Kramer N: Recurrence of
Wegener’s granulomatosis following renal transplantation. Br J
Rheumatol 1994; 33:869-871
49. Nyberg G, Akesson P, Norden G, Wieslander J: Systemic vasculitis in
a kidney transplant population. Transplantation 1997; 63:1273-1277
50. Lobbedez T, Comoz F, Renaudineau E Pujo M, Ryckelynck JP, Hurault de
Ligny B: Recurrence of ANCA positive glomerulonephritis immediately
after renal transplantation. Am J Kidney Dis 2003; 42:E2-E6
51. Goral S, Ynares C, Shappell SB, Snyder S, Feurer ID, Kazancioglu
R, Fogo AB, Helderman JH: Recurrent lupus nephritis in renal
transplant recipients revisited: It is not rare. Transplantation 2003;
75:651-656
52. Stone JH, Millward CL, Olson JL, Amend WJ, Criswell LA:
Frequency of recurrent lupus nephritis among ninety-seven renal
transplant patients during the cyclosporine era. Arthritis Rheum
1998; 41:678-686
53. Moroni G, Tantardini F, Gallelli B, Quaglini S, Banfi G, Poli F,
Montagnino G, Meroni P, Messa P, Ponticelli C: The long-term
prognosis of renal transplantation in patients with lupus nephritis.
Am J Kidney Dis 2005; 45:903-911
54. Denton MD, Galvanek EG, Singh A, Sayegh MH: Membranous
lupus nephritis in a renal allograft: Response to mycophenolate
mofetil therapy. Am J Transplant 2001; 1:288-292
55. Ahuja TS, Boughton J, Weiss V, Memon A, Remmers A Jr,
Rajaraman S: Late recurrence of lupus nephritis in a renal transplant
recipient: Response to mycophenolate mofetil. Am J Med Sci 2001;
322:166-169
56. Turner N, Lockwood CM, Rees AJ: Anti-glomerular basement
membrane antibody mediated nephritis. In: Schrier RW, Gottschalk
CW, eds. Diseases of the Kidney, 5th ed. Boston: Little, Brown &
Co 1993; 1865-1894
57. Khandelwal M, McCormick BB, Lajoie G, Sweet J, Cole E,
Cattran DC: Recurrence of anti-GBM disease 8 years after renal
transplantation. Nephrol Dial Transplant 2004; 19:491-494

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