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Böbrek Nakli Sonrası Tekrarlayan Glomerülonefritler

Recurrent Glomerulonephritis after Renal Transplantation

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2010
DOI: 
DOI 10.5262/tndt.2010.1003.16

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
The most frequent cause of recurrent disease after renal transplantation is recurrent glomerulonephritis. The risk factors for recurrence of glomerulonephritis are largely unknown or imprecise and prediction remains difficult. Among the recurrent glomerulonephritides, type II membranoproliferative glomerulonephritis, immunoglobulin A nephropathy, and focal and segmental glomerulosclerosis have the highest rates of recurrence. Recurrent disease usually presents with similar manifestations as the native disease. With regard to treatment of recurrent glomerular disease in the renal allograft, plasma exchange may be effective in reducing proteinuria in patients with early recurrence of focal and segmental glomerulosclerosis, but immunosuppressive therapy is generally ineffective in the prevention or treatment of recurrent disease. General supportive measures including strict blood pressure control and inhibition or blockade of the renin-angiotensin pathway are helpful in retarding the rate of deterioration in renal allograft function. Despite the risk of recurrence, kidney transplantation following primary glomerulonephritides enjoys graft and patient survival rates comparable to other causes of end-stage renal failure. With a few exceptions, living related renal transplantation is not contraindicated in view of the favorable outcome and the donor shortage. In this mini review we tried to discuss commonly encountered recurrent glomerulonephritides after renal transplantation
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Abstract (Original Language): 
Böbrek nakli sonrası en sık tekrarlayan hastalık grubu glomerülonefritlerdir. Bununla birlikte nakil sonrasında primer glomerüler hastalıkların nüks etmesine ilişkin risk faktörleri tam olarak aydınlatılamamıştır. Tip 2 membranoproliferatif glomerülonefrit, IgA nefropatisi, fokal segmental glomerülonefrit, böbrek nakli sonrasında en sık tekrarlayan glomerülonefritler olarak sıralanabilir. Nakil sonrası tekrarlayan glomerülonefritler, klinik olarak genellikle orijinal hastalılıklara benzer bulgular gösterir. Tekrarlayan glomerülonefritlerin tedavisinde immünosupresif tedavi rejimleri genellikle pek etkili olmamaktadır. Bazı tekrarlayan fokal segmental glomerülonefritlerde, erken dönemde plazma değişiminin proteinuriyi azalttığı gösterilmiştir. Kan basıncının sıkı kontrolü, renin anjiotensinojen aldosteron sisteminin baskılanması gibi genel önlemlerin renal allogreft fonksiyonundaki bozulmayı geciktirdiği bilinmektedir. Genel olarak bakıldığında, nakil sonrası tekrarlayan glomerülonefritlerin greft ve hasta sağkalım oranları çok kötü değildir. Glomerülonefriti olan hastalarda birkaç istisna dışında böbrek naklinin sonuçları yüz güldürücüdür. Biz bu derlememizde nakil sonrası tekrarlayan glomerülonefritler hakkında genel bir bilgi vermeyi amaçladık.
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  • 3
151-156
  • Turkish

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