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Tip 2 Diyabet Hastalarında Bilişsel İşlevler ve İdrar Albumin Atılımı Arasındaki İlişki

The Relationship Between Cognitive Function and Urinary Albumin Excretion in Type 2 Diabetic Patients

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2011
DOI: 
DOI 10.5262/tndt.2011.1001.07

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Objecti ve: In the current study we aimed to analyze the relationship between urinary albumin excretion (UAE) with cognitive dysfunction in Turkish Type 2 diabetic patients MA TERIAL and Metho ds: Patients with type 2 diabetes attending the Nephrology Clinic of Zonguldak Ataturk State hospital were included in the study. Medical history taking, physical examination, blood pressure measurements, biochemical analysis and collection of 24-hour urine specimens to determine creatinine clearance and UAE were performed. Cognitive function was evaluated by the Standardized Mini Mental State Examination (SMMSE). Res ults : In total, 195 type 2 diabetic patients whose mean SMMSE score was 26.6±2.2 were enrolled. The mean SMMSE scores of normoalbuminuric (71 patients), microalbuminuric (55 patients) and macroalbuminuric (69 patients) patients were 27.1 ±2.6, 26.7±1.9 and 26.0±1.9 respectively which were significantly different among the 3 groups (P: 0.009). Post-hoc analysis revealed that SMMSE scores were not significantly different between normoalbuminuric and microalbuminuric patients (P: 0.601) and between microalbuminuric and macroalbuminuric patients (P: 0.175). However, SMMSE scores significantly differed between normoalbuminuric and macroalbuminuric patients (P: 0.007). Stepwise multivariate linear regression analysis revealed that educational status (P<0.0001), age (P<0.0001), presence of cerebrovascular disease (P: 0.043), hemoglobin (P: 0.002), and logarithmically converted 24-hour UAE (P: 0.029) were found to be independently related with SMMSE scores. Conclusio n: 24-hour UAE is related with cognitive function in Turkish type 2 diabetic patients.
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Abstract (Original Language): 
Amaç: Bu çalışmamızda, Tip 2 diyabet hastalarında bilişsel işlevler ve idrar albumin atılımı arasındaki (İAA) ilişkiyi incelemeyi amaçladık. Gereç ve Yönte mler : Çalışmaya Zonguldak Ataturk Devlet Hastanesi Nefroloji Kliniğine başvuran Tip 2 diyabetik hastalar alındı. Her hastanın tıbbi özgeçmişleri sorgulandı, fizik muayeneleri yapıldı, kan basınçları ölçüldü, biyokimyasal analizleri yapıldı ve kreatinin klirensi ve İAA hesaplamak üzere 24 saatlik idrarı toplandı. Hastaların bilişsel işlevler Standardize Mini Mental Test (SMMT) yöntemi ile belirlendi. Bulgular: Çalışmaya toplam 195 tip 2 diyabetik hasta alındı. Hastaların ortalama SMMT puanı 26,6±2,2 idi. Normoalbuminurik (71 hasta), mikroalbuminurik (55 hasta) ve makroalbuminurik (69 hasta) hastaların ortalama SMMT puanları sırasıyla 27,1±2,6, 26,7±1,9 ve 26,0±1,9 idi ve 3 grup arasındaki SMMT puanları birbirinden anlamlı olarak farklıydı (P: 0,009). Gruplar arası karşılaştırma sonucunda SMMT puanları normoalbuminurik ve mikroalbuminurik hastalarda (P: 0,601) ve mikroalbuminurik ve makroalbuminurik hastalarda (P: 0,175) farklı bulunmadı. Bununla birlikte SMMT puanları, normoalbuminurik ve makroalbuminurik hastalar arasında anlamlı olarak farklı bulundu (P: 0,007). Basamaklı doğrusal regresyon analizi sonucunda eğitim durumu (P< 0,0001), yaş (P< 0,0001), serebrovasküler hastalık (P: 0,043), hemoglobin (P: 0,002) ve logaritmik dönüşüm yapılmış 24 saatlik İAA SMMT ile bağımsız ilişkili olduğu gözlendi. Sonuç: Tip 2 diyabet hastalarında 24 saatlik İAA ile bilişsel işlev arasında ilişki vardır.
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Afşar B et al: The relationship between Cognitive Function and Urinary Albumin
Excretion in Type 2 Diabetic Patients
Türk N efroloji D iyaliz ve Transplantasyon D ergisi
Turkish Nephrology, Dialysis and Transplantation Journal
Turk Neph Dial Transpl 2011; 20 (1): 38-45
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