Buradasınız

Anasayfa » Content

Kronik Böbrek Hastalarında Ürik Asit ve D vitamini Düzeyleri Arasındaki İlişki

The Association between Uric Acid and Vitamin D Levels in Patients with Chronic Kidney Disease

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2011
DOI: 
10.5262/tndt.2011.1002.08

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
OBJECTIV E: Hyperuricemia has been said to decrease vitamin D level. The purpose of this study is to examine whether there is an association between serum uric acid and vitamin D levels in patients with chronic kidney disease. MA TERIAL and M ETHODS: This study was performed in 35 patients with stage 3-4 chronic kidney disease. Biochemical tests, vitamin D level, 24 hour urine creatinine clearance, and proteinuria were analysed. Systolic and diastolic blood pressure were measured. The statistical analysis was performed using SPSS version 15.0. A P value of less than 0.05 was considered statistically significant. RESUL TS: Serum 1,25(OH)2D3 and 25(OH)D3 levels were low in 28 patients (80%) and in 24 patients (69%) respectively. Data analysis revealed statistically significant associations between serum uric acid and body mass index, 1,25(OH)2D3, creatinine, and phosphorus levels (P=0.04, P=0.03, P=0.01 and P=0.001, respectively). CONCLU SION: Our study demonstrates that there is a significant negative association between serum uric acid and 1,25(OH)2D3 levels. However, further studies are needed in a larger number of patients.
Bookmark/Search this post with
Abstract (Original Language): 
AMA Ç: Hiperüriseminin D vitamini düzeyini düşürdüğü ileri sürülmektedir. Bu çalışmanın amacı, kronik böbrek hastalarında serum ürik asit düzeyi ile D vitamini düzeyleri arasında bir ilişkinin olup olmadığını incelemektir. GEREÇ ve YÖN TEML ER: Çalışma, evre 3-4 kronik böbrek hastalığı olan 35 hastada yapıldı. Hastaların biyokimyasal incelemeleri, D vitamini düzeyleri, 24 saatlik idrarda kreatinin klirensleri ve proteinüri incelemeleri değerlendirildi. Sistolik ve diyastolik kan basıncı ölçüldü. İstatistiksel analizler bilgisayarda SPSS 15.0 Windows versiyonu kullanılarak gerçekleştirildi. p<0,05 değeri istatistiksel olarak anlamlı olarak kabul edildi. BUL GULA R: 1,25(OH)2D3 düzeyi 28 hastada (%80) ve 25(OH)D3 düzeyi ise 24 hastada (%69) düşük bulundu. Verilerin analizinde serum ürik asit düzeyi ile vücut kitle indeksi, 1,25(OH)2D3, kreatinin ve fosfor düzeyleri arasında istatistiksel olarak anlamlı ilişkiler saptandı (sırasıyla, p=0,04, p=0,03, p=0,01 ve p=0,001). SONU Ç: Çalışmamız, kronik böbrek hastalığı olan hastalarda serum ürik asit düzeyi ile 1,25(OH)2D3 düzeyleri arasında anlamlı negatif bir ilişki olduğunu göstermektedir. Ancak, daha fazla hasta üzerinde yapılacak çalışmalara ihtiyaç vardır.
FULL TEXT (PDF): 
PDF icon arastrmx_172977_20_pp_163-167.pdf
  • 2
163-167
  • Turkish

REFERENCES

References: 

1. KDOQI Clinical practice guidelines and clinical practice
recommendations for diabetes and chronic kidney disease. Am J
Kidney Dis 2007; 49: 13-19
2. Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada
LG, Feig DI, Shafiu M, Segal M, Glassock RJ, Shimada M, Roncal
C, Nakagawa T: Hypothesis: Could excessive fructose intake and
uric acid cause type 2 diabetes? Endocr Rev 2009; 30: 96-116
3. Feig DI, Johnson RJ: Hyperuricemia in childhood primary
hypertension. Hypertension 2003; 42: 247-252
4. Feig DI, Soletsky B, Johnson RJ: Effect of allopurinol on blood
pressure of adolescents with newly diagnosed essential hypertension:
A randomized trial. JAMA 2008; 300: 924-932
5. Feig DI: Uric acid: A novel mediator and marker of risk in chronic
kidney disease? Curr Opin Nephrol Hypertens 2009; 18: 526-530
6. Obermayr RP, Temml C, Gutjahr G, Knechtelsdorfer M, Oberbauer
R, Klauser-Braun R: Elevated uric acid increases the risk for kidney
disease. J Am Soc Nephrol 2008; 19: 2407-2413
7. Portale AA, Booth BE, Halloran BP, Morris RC Jr: Effect of
dietary phosphorus on circulating concentrations of 1,25-dihydroxy
vitamin D and immunoreactive parathyroid hormone in children
with moderate renal insufficiency. J Clin Invest 1984; 73:1580-1589
8. Hsu CH, Vanholder R, Patel S, De Smet RR, Sandra P, Ringoir
SM: Subfractions in uremic plasma ultrafiltrate inhibit calcitriol
metabolism. Kidney Int 1991; 40: 868-973
9. Li Y, Spataro BC, Yang J, Dai C, Liu Y: 1,25-Dihydroxy vitamin
D3 inhibits renal interstitial myofibroblast activation by inducing
hepatocyte growth factor expression. Kidney Int 2005; 68:
1500-1510
10. Melamed ML, Astor B, Michos ED, Hostetter TH, Powe NR,
Muntner P: 25 hydroxyvitamin D levels, race, and the progression
of kidney disease J Am Soc Nephrol 2009; 20: 2631-2639
11. Hsu CH, Patel SR, Young EW, Vanholder R: Effects of purine
derivatives on calcitriol metabolism in rats. Am J Physiol 1991;
260: 596-601
12. Takahashi S, Yamamoto T, Moriwaki Y, Tsutsumi Z, Yamakita J,
Higashino K: Decreased serum concentrations of 1,25(OH)2-
vitamin D3 in patients with gout. Metabolism 1998; 47: 336-338
13. Vanholder R, Patel S, Hsu CH: Effect of uric acid on plasma
levels of 1,25(OH)2D in renal failure. J Am Soc Nephrol 1993; 4:
1035-1038
167
Türk N efroloji D iyaliz ve Transplantasyon D ergisi Şengül E ve ark : KBH’da Ürik Asit ve D vitamini
Turkish Nephrology, Dialysis and Transplantation Journal
Turk Neph Dial Transpl 2011; 20 (2): 163-167
14. Heinig M, Johnson RJ: Role of uric acid in hypertension, renal
disease, and metabolic syndrome. Cleve Clin J Med 2006; 73:
1059-1064
15. Chonchol M, Shlipak MG, Katz R, Sarnak MJ, Newman AB,
Siscovick DS, Kestenbaum B, Carney JK, Fried LF: Relationship
of uric acid with progression of kidney disease. Am J Kidney Dis
2007; 50: 239-247
16. Bellomo G, Venanzi S, Verdura C, Saronio P, Esposito A, Timio M:
Association of uric acid with change in kidney function in healthy
normotensive individuals. Am J Kidney Dis 2010; 56: 264-272
17. Siu YP, Leung KT, Tong MK, Kwan TH: Use of allopurinol in
slowing the progression of renal disease through its ability to lower
serum uric acid level. Am J Kidney Dis 2006; 47: 51-59
18. Nakanishi N, Tatara K, Nakamura K, Suzuki K: Risk factors for the
incidence of hyperuricemia: A 6-year longitudinal study of middleaged
Japanese men. Int J Epidemiol 1999; 28: 888-893
19. Kanbay M, Solak Y, Dogan E, Lanaspa MA, Covic A: Uric acid in
hypertension and renal disease: The chicken or the egg? Blood Purif
2010; 30: 288-295

Thank you for copying data from http://www.arastirmax.com