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Hemodiyaliz Hastalarında Serum Selenyum Düzeyinin Hücre Aracılı Bağışıklığa ve Çok Değerlikli İnfluenza Aşısına Karşı Gelişen Antikor Yanıtına Etkileri

Effects of Serum Selenium Level on Cell-Mediated Immunity and on Antibody Response to Multivalent Influenza Vaccine in Hemodialysis Patients

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2012
DOI: 
DOI 10.5262/tndt.2012.1001.14

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
OBJECTIVE: End-stage renal disease (ESRD) patients are more prone to serious influenza virus infection than healthy subjects. Selenium (Se) play an important role in cellular and humoral immunity and serum Se levels were lower in hemodialysis patients. Studies have demonstrated that Se deficiency results in less reboust immune responses to vaccination and infections. We aimed to investigate the effect of serum Se levels on immune parameters and antibody response to multivalent influenza vaccine (MIV) in HD patients. MATE RIAL and Methods: Twenty-six HD patients (Group 1) and 11 healthy subjects (Group 2) were vaccinated with a trivalent inactivated MIV. In both groups, serum Se levels, CD3, CD4, CD4/ CD8 ratio, CD3+HLA-DR+ cell percentages and antibody response to MIV were determined before and 1 month after the vaccination. Res ults: There were statistically significant differences between Group 1 and Group 2 in terms of baseline serum Se levels, CD8, CD4/CD8 ratio, and CD3+HLA-DR cell percentages. One month after the vaccination, no significant changes were observed in any of the parameters except antibody titers with to baseline levels. ConclusI ons : We did not observe any difference in terms of Se levels and the immune parameters mentioned above before and 1 month after MIV vaccination in HD patients. Further studies investigating the link between Se status and clinical outcomes are needed in dialysis patients.
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Abstract (Original Language): 
Amaç : Son dönem böbrek yetmezliği (SDBY) olan hastalar sağlıklı bireylere oranla ciddi influenza virüs enfeksiyonuna daha yatkındırlar. Selenyum (Se) hücresel ve hümoral bağışıklıkta önemli bir rol oynamaktadır ve hemodiyaliz hastalarında serum Se düzeyleri düşüktür. Yapılan çalışmalarda Se eksikliği olanlarda aşılara ve enfeksiyon hastalıklarına yeterli bağışıklık yanıtının oluşmadığı gösterilmiştir. Çalışmamızda SDBY hastalarında serum Se düzeyinin bağışıklık göstergeleri ve çok değerlikli influenza aşısına (MIV) antikor yanıtı üzerine etkisini göstermeyi hedefledik. GEREÇ ve Yöntemler: 26 hemodiyaliz hastası (grup 1) ve 11 sağlıklı kontrol (grup 2) trivalan MIV ile aşılandı. Aşı öncesi ve 1 ay sonrasında serum Se, CD3, CD4, CD4/ CD8 oranı, CD3+HLADR+ hücre oranları değerlendirildi. Bulgular : Grup 1’deki hastaların grup 2’deki hastalara göre bazal serum Se düzeyleri, CD4/CD8 oranı düşük, CD8 ve CD3+HLA-DR hücre yüzdeleri ise yüksek bulundu. Her iki grubta MIV aşılanma sonrasında antikor düzeyleri dışında Se düzeyleri, CD8, CD4/CD8 oranı ve CD3+HLA-DR hücre yüzdelerinde anlamlı bir fark bulunmadı. Sonuç: Hemodiyaliz hastalarında, MIV aşısı öncesi ve 1 ay sonrasında serum Se ve bağışıklık göstergeleri üzerinde herhangi bir fark saptamadık. Hemodiyaliz hasta grubunda Se düzeyi ile klinik sonuçları değerlendiren çalışmalara gereksinim vardır.
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