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Yurtdışında Akraba Olmayan Canlıdan Yapılan Böbrek Nakli: Birçok Bilinmeyen Var

Paid Living-Unrelated Renal Transplantation Abroad: Too Much Unknown

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DOI: 
DOI 10.5262/tndt.2012.1002.07
Abstract (2. Language): 
Obj ect Ive: Despite the unethical characteristic and unfavorable consequences, paid livingunrelated renal transplantation is still considered as an option for end-stage renal disease patients. This study aimed to compare the medical and surgical complications along with allograft functions of PLURT patients with age and gender matched transplant recipients who received a living or deceased donor kidney at our center. Mat erIal and Methods: End-stage renal disease patients received PLURT (group 1) in a foreign country and age, and gender matched renal transplant recipients that received renal transplantation from living-related donors (LRT patients; group 2) and deceased donors (DDRT patients; group 3) followed between 2003-2010 at our transplantation center were included in the study. Results : There were no significant differences between groups (Group 1&2 and group 1&3) regarding age, sex, urea, creatinine, creatinine clearance, and proteinuria. Data about patients that received renal transplantation from living-related and deceased-donors at our center were sufficient when compared with PLURT patients. PLURT has a negative impact on patients’ survival because of surgical and medical problems. Conc lusIon : In the present study, PLURT, LRT and DDRT patients had early and late complications of renal transplantation which were similarly seen in recent studies. The main problem for unfavorable results of PLURT is the commercial aspect of renal transplantation without considering the risks for ESRD patients.
Abstract (Original Language): 
Amaç : Son dönem böbrek yetmezliği bulunan hastalar etik olmamasına ve olumsuz sonuçlara karşın yabancı ülkelerde akraba dışı canlı vericilerden nakil olmaktadırlar. Çalışmamızın amacı, dış ülkelerde canlıdan böbrek nakli yapılan ve sonrasında merkezimizde izlenen hastalarla merkezimizde canlıdan ve kadavradan yapılan nakil yapılan hastaların böbrek işlevlerini, mortalite ve morbiditeleri karşılaştırmaktır. GERE Ç ve YöntemLER: Yaş, cinsiyet ve diyaliz süreleri uyumlu olan SDBY hastalar, dış merkezlerde canlıdan nakil yapılan hastalar (Grup 1), merkezimizde canlıdan nakil yapılan hastalar (Grup 2) ve yine merkezimizde kadavradan nakil yapılan hastalar (Grup 3) çalışmaya alındı. Bulgular: Her 3 grup arasında yaş, cinsiyet, kreatinin, kreatinin klirensi ve proteinüri açısından anlamlı fark yoktu. Grup 2 ve 3’te bulunan hastaların nakil öncesi ve sonrası verileri yeterli iken, grup 1’deki hastalarda birçok bilinmeyen vardı. Grup 3’teki hastaların cerrahi ve medikal komplikasyonlar nedeniyle yaşam süresi kısalmıştı. Son uç: Çalışmamızda, her 3 grupta böbrek naklinin erken ve geç komplikasyonları açısından anlamlı fark yoktu. Grup 1’deki hastalarda medikal ve cerrahi komplikasyonlar çok fazla saptandı. Bu durum yurt dışında olguların yeterince değerlendirilmeden nakil yapılmasına bağlandı.
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REFERENCES

References: 

1. Divakar D, Thiagarajan CM, Reddy KC: Ethical aspects of renal
transplantation in India. Transplant Proc 1998; 30 (7): 3626
2. Abouna GM: Negative impact of trading in human organs on the
development of transplantation in the Middle East. Transplant Proc
1993; 25( 3): 2310-2313
3. Sever MS, Ecder T, Aydin AE, Türkmen A, Kiliçaslan I, Uysal
V, Eraksoy H, Calangu S, Carin M, Eldegez U: Living unrelated
(paid) kidney transplantation in Third-World countries: High risk of
complications besides the ethical problem. Nephrol Dial Transplant
1994; 9 (4): 350-354
4. Salahudeen AK, Woods HF, Pingle A, Nur-El-Huda Suleyman M,
Shakuntala K, Nandakumar M, Yahya TM, Daar AS: High mortality
among recipients of bought living-unrelated donor kidneys. Lancet
1990; 336 (8717): 725-728
5. The Declaration of Istanbul on organ trafficking and transplant
tourism. Rev Med Inst Mex Seguro Soc 2008; 46 (6): 625-630
6. Solak Y, Atalay H, Anil M, Aydogdu I, Tonbul HZ: Cost of paid
transplantation abroad: Possible donor-origin early multiple
myeloma in a renal transplant recipient treated using bortezomib.
Transplant Proc 2010; 42 (7): 2813-2815
7. Gjertson DW, Cecka JM: Living unrelated donor kidney
transplantation. Kidney Int 2000; 58 (2): 491-499
8. Foss A, Leivestad T, Brekke IB, Fauchald P, Bentdal O, Lien B,
Pfeffer P, Sødal G, Albrechtsen D, Søreide O, Flatmark A: Unrelated
living donors in 141 kidney transplantations: A one-center study.
Transplantation 1998; 66 (1): 49-52
9. Terasaki PI, Cecka JM, Gjertson DW, Takemoto S: High survival
rates of kidney transplants from spousal and living unrelated donors.
N Engl J Med 1995; 333 (6): 333-336
10. D’Alessandro AM, Pirsch JD, Knechtle SJ, Odorico JS, Van der
Werf WJ, Collins BH, Becker YT, Kalayoglu M, Armbrust MJ,
Sollinger HW: Living unrelated renal donation: The University of
Wisconsin experience. Surgery 1998; 124 (4): 604-610; discussion
610-611
11. Mansy H, Khalil A, Aly TF, Filobbos P, al-Dusari S, al-Shareef Z,
Shlash S: Outcome of commercial renal transplantation: Two years
follow-up. Nephron 1996; 74 (3): 613-616
12. Colakoğlu M, Akpolat T, Arik N, Utaş C, Arinsoy T, Sindel S, Sungur
C, Yasavul U, Turgan C, Cağlar S: Outcome of renal transplantation
from foreign unrelated living donors in Turkey. Nephron 1995; 71
(2): 244-245
13. Lei C, Abdullah K, Morad Z, Suleiman AB: Surgical complications
of living unrelated kidney transplantations in a Third-World country.
Transplant Proc 1992; 24 (5): 1815
14. Sever MS, Kazancioğlu R, Yildiz A, Türkmen A, Ecder T, Kayacan
SM, Celik V, Sahin S, Aydin AE, Eldegez U, Ark E: Outcome of
living unrelated (commercial) renal transplantation. Kidney Int
2001; 60 (4): 1477-1483
15. Gill J, Madhira BR, Gjertson D, Lipshutz G, Cecka JM, Pham PT,
Wilkinson A, Bunnapradist S, Danovitch GM: Transplant tourism
in the United States: A single-center experience. Clin J Am Soc
Nephrol 2008; 3 (6): 1820-1828
16. Canales MT, Kasiske BL, Rosenberg ME: Transplant tourism:
Outcomes of United States residents who undergo kidney
transplantation overseas. Transplantation 2006; 82 (12): 1658-1661
17. Prasad GV, Shukla A, Huang M, RJ DAH, Zaltzman JS: Outcomes
of commercial renal transplantation: A Canadian experience.
Transplantation 2006; 82 (9): 1130-1135
18. Hussein MM, Mooij JM, Roujouleh H, el-Sayed H: Commercial
living-nonrelated renal transplantation: Observations on early
complications. Transplant Proc 1996; 28 (3): 1941-1944
19. Chugh KS, Sakhuja V, Jain S, Talwar P, Minz M, Joshi K, Indudhara
R: High mortality in systemic fungal infections following renal
transplantation in Third-World Countries. Nephrol Dial Transplant
1993; 8 (2): 168-172
20. Chugh KS, Jha V: Commerce in transplantation in Third World
countries. Kidney Int 1996; 49 (5): 1181-1186
21. Friedlaender MM, Gofrit O, Eid A: Unrelated-living-donor kidney
transplantation. Lancet 1993; 342 (8878): 1061-1062
22. Crooks VA, Kingsbury P, Snyder J, Johnston R: What is known
about the patient’s experience of medical tourism? A scoping
review. BMC Health Serv Res 2010; 10: 266
23. Eggertson L: Wait-list weary Canadians seek treatment abroad.
CMAJ. 2006; 174 (9): 1247
24. Leahy AL: Medical tourism: The impact of travel to foreign
countries for healthcare. Surgeon 2008; 6 (5): 260-261
25. Registry of Nephrology, Dialysis and Transplantation in Turkey.
Istanbul: Nobel Tıp Kitapevi, 2008
26. Rizvi AH, Naqvi AS, Zafar NM, Ahmed E: Regulated compensated
donation in Pakistan and Iran. Curr Opin Organ Transplant 2009; 14
(2): 124-128
27. Shimazono Y: The state of the international organ trade: A
provisional picture based on integration of available information.
Bull World Health Organ 2007; 85 (12): 955-962
28. Delmonico FL: The implications of Istanbul Declaration on organ
trafficking and transplant tourism. Curr Opin Organ Transplant
2009; 14 (2): 116-119

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