Sepsis ve Böbrek: Patogenez ve Tedavide Yeni Gelişmeler

1. Baskan S: Sepsis ve böbrek yetmezliği. ANKEM Dergisi 1999; 13
(3): 194-197
2. Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of
sepsis in the United States from 1979 through 2000. N Engl J Med
2003; 348: 1546-1554
3. Uzun O, Akalİn HE, Hayran M, Unal S: Factors influencing
prognosis in gram-negative bacteraemia: Evaluation of 448 episodes
in a Turkish university hospital. Clin Infect Dis 1992; 15: 866-873
4. Schrier RW, Wang W: Acute renal failure and sepsis. N Engl J Med
2004; 351: 159-169
5. Akıncı SB: Sepsis ve akut böbrek yetersizliği. Türk Yoğun Bakım
Derneği Dergisi 2010; 8 (1): 7-17
6. Bone RC: Sepsis, the sepsis syndrome, multiorgan failure: A plea
for comparable definitions. Ann Intern Med 1991; 114: 332-333
7. Cohen J: The immunopathogenesis of sepsis. Nature 2002; 420:
885-891
8. Hotchkiss RS, Karl IE: The Pathophysiology and treatment of
sepsis. N Engl J Med 2003; 348(2): 138-150
9. Cinel I, Dellinger R: Advances in pathogenesis and management of
sepsis. Curr Opin Infect Dis 2007; 20 (4): 345-352
10. Wan L, Bellomo R, Giantomasso DD, Ronco C: The pathogenesis
of septic acute renal failure. Curr Opin Crit Care 2003; 9: 496-502
11. Bone RC, Grodzin CJ, Balk RA: Sepsis: A new hypothesis for
pathogenesis of the disease process. Chest 1997; 112: 235-243
12. Karaali R, Tabak F: Sepsis patogenezi. Klinik Gelişim 2009; 22:
71-76
13. Cavaillon JM, Adib-Conquy M, Fitting C, Adrie C, Payen D:
Cytokine cascade in sepsis. Scand J Infect Dis 2003; 35 (9): 535-
544
14. Tiwari SC , Vikrant S: Sepsis and the kidney: Review article.
Journal of Indian Academy of Clinical Medicine 2000;5(1): 44-54
15. Wan L, Bagshaw SM, Langenberg C, Saotome T, May C, Bellomo
R: Pathophysiology of septic acute kidney injury: What do we really
know? Crit Care Med 2008; 36 (4 Suppl): S198-203
16. Langenberg C, Bagshaw SM, May CN, Bellomo R: The
histopathology of septic acute kidney injury: A systematic review.
Crit Care 2008; 12: R38
17. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP,
Matuschak GM: Apoptotic cell death in patients with sepsis, shock
and multiple organ dysfunction. Crit Care Med 1999; 27: 1230-
1251
18. Rosenberg IK, Gupta SL, Lucas CE, Khan AA, Rosenberg BF: Renal
insufficiency after trauma and sepsis. A prospective functional and
ultrastructural analysis. Arch Surg 1971; 103: 175-183
19. Zappacosta AR, Ashby BL: Gram-negative sepsis with acute renal
failure. Occurence from acute glomerulonephritis. JAMA 1977;
238: 1389-1390
20. Henkart PA: Apoptosis: O death, where is thy sting? J Immunol
1995; 154 (10): 4905-4908
21. Steller H: Mechanisms and genes of cellular suicide. Science 1995;
267 (5203): 1445-1449
22. Hetts SW: To die or not to die: An overview of apoptosis and its role
in disease. JAMA 1998; 279: 300-307
23. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry
NA, Wong WW, Yuan J: Human ICE/CED-3 protease nomenclature.
Cell 1996; 87 (2): 171
24. Earnshaw WC, Martins LM, Kaufmann SH: Mammalian caspases:
Structure, activation, substrates, and functions during apoptosis.
Annu Rev Biochem 1999; 68: 383-424
25. Thornberry NA, Lazebnik Y: Caspases: Enemies within. Science
1998; 281 (5381): 1312-1316
26. Hengardner MO: The biochemistry of apoptosis. Nature 2000; 407:
770-776
27. Ortiz A, González Cuadrado S, Lorz C, Egido J: Apoptosis in renal
diseases. Front Biosci 1996; 1: 30-47
28. Jo SK, Cha DR, Cho WY, Kim HK, Chang KH, Yun SY, Won
NH: Inflammatory cytokines and lipopolysaccharide induce Fasmediated
apoptosis in renal tubular cells. Nephron 2002; 91: 406-
415
29. Messmer UK, Briner VA, Pfeilschifter J: Tumor necrosis factoralpha
and lipopolysaccharide induce apoptotik cell death in bovine
glomerular endothelial cells. Kidney Int 1999; 55: 2322-2337
30. Lerolle N, Nochy D, Guérot E, Bruneval P, Fagon JY, Diehl JL, Hill
G: Histopathology of septic shock induced renal injury: Apotosis
and leukocytic infiltration. Intensive Care Med 2010; 36: 471-478
31. Jacobs R, Honore PM, Joannes-Boyau O, Boer W, De Regt J, De
Waele E, Collin V, Spapen HD: Septic Acute Kidney Injury: The
Culprit Is Inflammatory Apoptosis rather than Ischemic Necrosis.
Blood Purif 2011; 32: 262-265
32. Homsi E, Janino P, de Faria JB: Role of caspases on cell death,
inflammation, and cell cycle in glycerol-induced acute renal failure.
Kidney Int 2006; 69: 1385-1392
33. Cantaluppi V, Assenzio B, Pasero D, Romanazzi GM, Pacitti
A, Lanfranco G, Puntorieri V, Martin EL, Mascia L, Monti G,
Casella G, Segoloni GP, Camussi G, Ranieri VM: Polymyxin-B
hemoperfusion inactivates circulating proapoptotic factors.
Intensive Care Med 2008; 34: 1638-1645
34. Wang W, Bansal S, Falk S, Ljubanovic D, Schrier RW: Ghrelin
protects mice against endotoxemia- induced acute kidney injury.
Am J Physiol Renal Physiol 2009; 297: F1032-F1037
35. Simon F, Giudici R, Scheuerle A, Gröger M, Asfar P, Vogt JA,
Wachter U, Ploner F, Georgieff M, Möller P, Laporte R, Radermacher
P, Calzia E, Hauser B: Comparison of cardiac, hepatic, and renal
effects of arginine vasopressin and noradrenaline during porcine
fecal peritonitis: A randomized controlled trial. Crit Care 2009; 13:
R113
36. Bahlmann FH, Fliser D: Erythropoietin and renoprotection. Curr
Opin Nephrol Hypertens 2009; 18: 15-20
37. Jungers P, Choukroun G, Oualim Z, Robino C, Nguyen AT, Man
NK: Beneficial influence of recombinant human erythropoietin
therapy on the rate of progression of chronic renal failure in
predialysis patients. Nephrol Dial Transplant 2001; 16: 307-312
38. Schrier RW, Zolty E, Wang W: Sepsis and acute renal failure. In:
Vincent JL, ed. Yearbook of intensive care and emergency medicine.
Germany: Springer-Verlag Berlin Heidelberg 2006: 673-679
39. Langenberg C, Bellomo R, May C, Wan L, Egi M, Morgera S.
Renal blood flow in sepsis. Crit Care 2005; 9: 363-374
40. Cankurtaran M, Kıykım A: Sepsiste renal hemodinami ve
mediyatörler. Erciyes Tıp Dergisi 2002; 24: 202-208
41. Brenner M, Schaer GL, Mallory DL, Suffredini AF, Parillo JE:
Detection of renal blood flow abnormalities in septic and critically
ill patients using a newly designed indwelling thermodilution renal
vein catheter. Chest 1990; 98: 170-179
42. Langenberg C, Wan L, Egi M, May CN, Bellomo R: Renal blood
flow and function during recovery from experimental septic acute
kidney injury. Intensive Care Med 2007; 33: 1614-1618
43. Mete B: Sepsiste böbrek ve karaciğer. Güncel Bilgiler Işığında
Sepsis Sempozyum Dizisi 2006; 51: 35-43
44. Knotek M, Rogachev B, Wang W, Ecder T, Melnikov V, Gengaro PE,
Esson M, Edelstein CL, Dinarello CA, Schrier RW: Endotoxemic
renal failure in mice: Role of tumor necrosis factor independent of
inducible nitric oxide synthase. Kidney Int 2001; 59: 2243-2249
45. Baud L, Oudinet JP, Bens M, Noe L, Peraldi MN, Rondeau E,
Etienne J, Ardaillou R: Production of tumor necrosis factor by rat
mesangial cells in response to bacterial lipopolysaccharide. Kidney
Int 1989; 35: 1111-1118
46. Cunningham PN, Dyanov HM, Park P, Wang J, Newell KA, Quigg
RJ: Acute renal failure in endotoxemia is caused by TNF acting
directly on TNF receptor-1 in kidney. J Immunol 2002; 168: 5817-
5823
47. Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards
V: Injurious mechanical ventilation and end-organ epithelial cell
apoptosis and organ dysfunction in an experimental model of acute
respiratory distress syndrome. JAMA 2003; 289: 2104-2112
48. Jane Gaddard, Allan D Cumning: Renal alteration in the septic
patients in Claudio Ronco & Rinaldo Bellmo (eds). Critical Care
Nephrology Kluwer Academic Publishers, 1998; 1: 517-526
49. Anupam Agarwal, Leopoldo Raij: Endothelial dysfunction in ARF
in Claudio Ronco & Rinaldo Bellmo (eds). Critical Care Nephrology
Kluwer Academic Publishers 1998; 1: 527-550
50. Klenzak J, Himmelfarb J: Sepsis and the kidney. Crit Care Clin
2005; 21: 211-222
51. Lombardi R, Zampedri L, Rodriguez I, Alegre S, Ursu M, Di Fabio
M: Prognosis in acute renal failure of septic origin: A Multivariate
Analysis. Ren Fail 1998; 20 (5): 725-732
52. Levy B: Lactate and shock state: The metabolic view. Curr Opin
Crit Care 2006; 12: 315-321
53. Nguyen HB, Rivers EP, Knoblich BP, Jacobsen G, Muzzin A,
Ressler JA, Tomlanovich MC: Early lactate clearance is associated
with improved outcome in severe sepsis and septic shock. Crit Care
Med 2004; 32: 1637-1634
54. Mackenzie I, Woodhouse J: C-reactive protein concentrations during
bacteraemia: A comparison between patients with and without liver
dysfunction. Intensive Care Med 2006; 32: 1344-1351
55. Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY: Procalcitonin
as a diagnostic test for sepsis in critically ill adults and after surgery
or trauma: A systematic review and meta-analysis. Crit Care Med
2006; 34: 1996-2003
56. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber
PR, Tamm M, Müller B: Effect of procalcitonin-guided treatment
on antibiotic use and outcome in lower respiratory tract infections:
Cluster-randomised, single-blinded intervention trial. Lancet 2004;
363: 600-607
Luyt CE, Guérin V, Combes A, Trouillet JL, Ayed SB, Bernard M,
Gibert C, Chastre J: Procalcitonin kinetics as a prognostic marker of
ventilator-associated pneumonia. Am J Respir Crit Care Med 2005;
171: 48-53
58. Jensen JU, Heslet L, Jensen TH, Espersen K, Steffensen P, Tvede M:
Procalcitonin increase in early identification of critically ill patients
at high risk of mortality. Crit Care Med 2006; 34: 2596-2602
59. Gibot S, Kolopp-Sarda MN, Béné MC, Cravoisy A, Levy B, Faure
GC, Bollaert PE: Plasma level of a triggering receptor expressed on
myeloid cells-1: Its diagnostic accuracy in patients with suspected
sepsis. Ann Intern Med 2004; 141: 9-15
60. Yapıcı N, Cinel I: Sepsis tedavisinde erken yaklaşımın önemi. Türk
Anest Rean Der Dergisi 2007; 35 (6): 379-392
61. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen
J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G,
Zimmerman JL, Vincent JL, Levy MM; Surviving Sepsis Campaign
Management Guidelines Committee: Surviving Sepsis Campaign
guidelines for management of severe sepsis and septic shock. Crit
Care Med 2004; 32: 858-873
62. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke
R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T,
Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri
M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender
JS, Zimmerman JL, Vincent JL; International Surviving Sepsis
Campaign Guidelines Committee; American Association of Critical-
Care Nurses; American College of Chest Physicians; American
College of Emergency Physicians; Canadian Critical Care Society;
European Society of Clinical Microbiology and Infectious Diseases;
European Society of Intensive Care Medicine; European Respiratory
Society; International Sepsis Forum; Japanese Association for Acute
Medicine; Japanese Society of Intensive Care Medicine; Society
of Critical Care Medicine; Society of Hospital Medicine; Surgical
Infection Society; World Federation of Societies of Intensive and
Critical Care Medicine: Surviving Sepsis Campaign: International
guidelines for management of severe sepsis and septic shock: 2008.
Crit Care Med 2008; 36: 296-327
63. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S,
Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A,
Cheang M: Duration of hypotension before initiation of effective
antimicrobial therapy is the critical determinant of survival in
human septic shock. Crit Care Med 2006; 34 (6): 1589-1596
64. Lameire NH, De Vriese AS, Vanholder R: Prevention and nondialytic
treatment of acute renal failure. Curr Opin Crit Care 2003; 9: 481-
490
65. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R;
SAFE Study Investigators: A comparison of albumin and saline for
fluid resuscitation in the intensive care unit. N Engl J Med 2004;
350 (22): 2247-2256
66. Sprung CL, Anane D, Keh D, Moreno R, Singer M, Freivogel K,
Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart
K, Cuthbertson BH, Payen D, Briegel J; CORTICUS Study Group:
Hydrocortisone therapy for patients with septic shock. N Engl J
Med 2008; 358 (2): 111-124
67. Montori VM, Bistrian BR, McMahon MM: Hyperglycemia in
acutely ill patients. JAMA 2002; 288: 2167-2169
68. Vanhorebeek I, Van den Berghe G: Diabetes of injury: Novel
insights. Endocrinol Metab Clin North Am 2006; 35: 859-872
69. Hansen TK, Thiel S, Wouters PJ, Christiansen JS, Van den Berghe
G: Intensive insulin therapy exerts anti-inflammatory effects in
critically ill patients and counteracts the adverse effect of low
mannose-binding lectin levels. J Clin Endocrinol Metab 2003; 88:
1082-1088
70. Langouche L, Vanhorebeek I, Vlasselaers D, Vander Perre S,
Wouters PJ, Skogstrand K, Hansen TK, Van den Berghe G: Intensive
insulin therapy protects the endothelium of critically ill patients. J
Clin Invest 2005; 115: 2277-2286
71. Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V,
Bellomo R, Cook D, Dodek P, Henderson WR, Hebert PC, Heritier
S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh
JA, Norton R, Potter J, Robinson BG, Ronco JJ: Intensive versus
conventional glucose control in critically ill patients. N Engl J Med
2009; 360: 1283-1297
72. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters
PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R:
Intensive insulin therapy in the medical ICU. N Engl J Med 2006;
354: 449-461
73. Allen DA, Harwood S, Varagunam M, Raftery MJ, Yaqoob MM:
High glucose-induced oxidative stres causes apoptosis in proximal
tubular epithelial cells and is mediated by multiple caspases. FASEB
J 2003; 17: 908-910
74. Schetz M, Vanhorebeek I, Wouters PJ, Wilmer A, Van den Berghe
G: Tight blood glucose control is renoprotective in critically ill
patients. J Am Soc Nephrol 2008; 19 (3): 571-578
75. Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P,
La Greca G: Effects of different doses in continuous veno-venous
haemofiltration on outcomes of acute renal failure: A prospective
randomised trial. Lancet 2000; 356: 26-30
76. Cole L, Bellomo R, Hart G: A phase II randomized, controlled trial
of continuous hemofiltration in sepsis. Crit Care Med 2002; 30:
100-106
77. Ketteler M, Cetto C, Kirdorf M, Jeschke GS, Schäfer JH, Distler A:
Nitric Oxide in sepsis syndrome: Potential treatment of septic shock
by nitric oxide synthase antagonists. Kidney Int Suppl 1998; 64:
S27-S30
78. Anzuetto A, Beale R, Holzapfel, Ameson C: The Glaxo Wellcome
International Septic shock study group. Multicentre placebo
controlled double blind study of the nitric oxide synthase inhibitor
546 C 88 in patients with septic shock. Effect on resolution of shock
and survival. Int Care Med 1997; 23 (Suppl): S57