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Yoğun Bakım Hastalarında Radyokontrast Nefropati Gelişiminde Nötrofi l Jelatinazla İlişkili Lipokalin Prediktivitesi

The Predictivity of Neutrophil Gelatinase Associated Lipocaline in the Development of Radiocontrast-Induced Nephropathy in the Intensive Care Unit Patients

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2013
DOI: 
10.5262/tndt.2013.1002.05

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
OBJECTIVE: The aim of this study is to investigate the predictive value of neutrophil gelatinase associated lipocaline (NGAL) levels in the development of radiocontrast-induced nephropathy (rin) in intensive care unit patients. MATERIAL and METHODS: Forty patients (female: male was 23:17) with a mean age of 73.7± 9.7 yrs (range= 60-94 yrs) were included in the study. Lopromide 623mg/dl (ultravist 300) (iv) was administered at a dose of 1.5 ml/kg. NGAL measurements were performed with the ELISA method on serum samples (cut-off >25 ng/ml). RESULTS: Eight patients were diagnosed as RIN. Five of these had 20% or more increases in NGAL levels. Cases who developed RIN had a statistically signifi cant and direct correlation between the increases in NGAL and serum creatinine levels (p= 0.02). When the means of NGAL levels were compared before and six hours after the procedure, there was a signifi cant increase after the procedure (p<0.001). For 32 patients who did not develop RIN, there was no statistically signifi cant difference between NGAL levels before and six hours after the procedure (p>0.05). CONCLUSION: When compared to creatinine, plasma NGAL levels help to establish the diagnosis of RIN at a much earlier stage.
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Abstract (Original Language): 
AMAÇ: Bu çalışmanın amacı, yoğun bakım hastaları arasından radyokontrast nefropatisi (RIN) gelişen hastalarda nötrofi l jelatinazla ilişkili lipokalin (NGAL) prediktivitesini araştırmaktır. GEREÇ ve YÖNTEMLER: Çalışmaya ortalama yaşı 73,7± 9,7 (aralık=60-94) olan kırk hasta (kadın:erkek oranı 23:17) alındı. Iopromide 623 mg/dl (ultravist 300) (iv) olarak 1,5 ml/kg dozda verildi. NGAL ölçümleri serum örneklerinde Elisa metodu ile yapıldı (cut-off >25 ng/ml). BULGULAR: Sekiz hastada RIN tanısı konuldu. Bunlardan 5’inde NGAL seviyelerinde %20 veya daha fazla artış vardı. RIN gelişen olguların NGAL ile serum kreatinin düzeylerindeki artışlar arasında istatistiksel olarak anlamlı ve doğrudan ilişki vardı (p=0,02). NGAL düzeylerinin ortalamaları işlemden önce ve 6 saat sonra karşılaştırıldığı zaman işlemden sonra anlamlı bir yükselme vardı (p<0,001). RIN gelişmeyen 32 hastada, işlemden önce ve 6 saat sonraki NGAL düzeyleri arasında istatistiksel olarak anlamlı bir fark yoktu (p>0,05). SONUÇ: Kreatininle mukayese edildiği zaman, plazma NGAL düzeyleri RIN tanısının daha erken bir evrede konulmasına yardımcı olabilir.
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REFERENCES

References: 

1. Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M,
Mintz GS, Lansky AJ, Moses JW, Stone GW, Leon MB, Dangas G:
A simple risk score for prediction of contrast-induced nephropathy
after percutaneous coronary intervention: Development and initial
validation. J Am Coll Cardiol 2004; 44(7): 1393-1399
2. Alonso A, Lau J, Jaber Bl, Weintraub A, Sarnak MJ: Prevention
of radiocontrast nephropathy with n-acetylcysteine in patients with
chronic kidney disease: A meta-analysis of randomized, controlled
trials. Am J Kidney Dis 2004; 43(1): 1-9
3. Jefferson JA, Schrier RW: Pathophysiology and etiology of
acute renal failure. In: Feehally J, Floege J, Johnson R (eds),
Comprehensive Clinical Nephrology (3rd ed). Philadelphia:
Elsevier, 2007; 765-766
4. Lamaire N, Biesen WV, Vpnholder R: Epidemiology, clinical
evaluation and prevention of acute renal failure. In: Feehally J,
Floege J, Johnson R (eds), Comprehensive Clinical Nephrology
(3rd ed). Philadelphia: Elsevier, 2007; 779-780
5. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz
A; NGAL Meta-analysis investigator group: Accuracy of neutrophil
gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis
in acute kidney injury: A systematic review and meta-analysis. Am
J Kidney Dis 2009; 54(6): 1012-1024
6. Van Biesen W, Van Massenhove J, Hoste E, Vanholder R: Defi ning
acute kidney injury: Playing hide-and-seek with the unknown man?
Nephrol Dial Transplant 2011; 26(2): 399-401
7. Schmidt-Ott KM: Neutrophil gelatinase-associated lipocalin as a
biomarker of acute kidney injury-where do we stand today? Nephrol
Dial Transplant 2011; 26(3): 762-764
8. Kidney disease: Improving global outcomes (KDIGO) Acute
Kidney Injury Work Group. KDIGO clinical practice guideline for
acute kidney ınjury. Kidney Inter suppl 2012; 2: 1-138
9. Mishra J, Dent C, Tarabishi R, Mitsnefes Mm, Ma Q, Kelly C, Ruff
Sm, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P:
Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker
for acute renal injury after cardiac surgery. Lancet 2005; 365 (9466):
1231-1238
10. Hirsch R, Dent C, Pfriem H, Allen J, Beekman Rh 3rd, Ma Q,
Dastrala S, Bennett M, Mitsnefes M, Devarajan P: NGAL is an early
predictive biomarker of contrast-induced nephropaty in children.
Pediatr Nephrol 2007; 22(12): 2089-2095

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