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Üremik Hastaların Nonüremik Kontrollerle Gastroskopik Bulgular ve Helicobacter Pylori Pozitifl iği Açısından Karşılaştırılması

Comparison of Uremic Patients with Non-Uremic Controls Regarding Gastroscopic Findings and Helicobacter Pylori Positivity

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DOI: 
10.5262/tndt.2013.1003.03

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Abstract (2. Language): 
OBJECTIVE: We aimed to investigate the relationship between gastroscopic fi ndings and Helicobacter pylori (H. pylori) in uremic patients; and to compare them with the normal population. MATERIAL and METHODS: Sixty two patients who had dyspeptic symptoms and who had a gastroscopic examination were included. These patients were grouped as hemodialysis group (n=29); peritoneal dialysis group (n=12), predialysis group (n=29) and the control group (n=29). RESULTS: On pathological examinations of biopsies obtained for all participants of the study; 20 patients had gastritis, two had duodenitis, 14 had H. pylori positivity and one had malignancy in the hemodialysis group. Of the 12 peritoneal dialysis patients; 11 had gastritis, three had duodenitis and seven had H. pylori positivity. Twenty eight of the 29 predialysis patients had gastritis, two had duodenitis, 22 had H. pylori positivity. Of the 29 control subjects; 27 had gastritis, seven had duodenitis and 19 had H. pylori positivity. There was no difference between groups regarding gastroscopic and histopathological fi ndings. The use of proton pump inhibitors did not affect these fi ndings. CONCLUSION: In spite of the differences in gastric mucosal physiology in uremia; the rate of H. pylori infection and gastroscopic fi ndings are not different in uremic and nonuremic population.
Abstract (Original Language): 
AMAÇ: Üremik hastalarda gastroskopik bulgular ile Helicobacter pylori (H. pylori) pozitifl iği arasındaki ilişkiyi incelemeyi; ve bu hastaları normal popülasyonla karşılaştırmayı amaçladık. GEREÇ ve YÖNTEMLER: Dispeptik semptomları olan ve gastroskopik muayenesi yapılmış olan 62 hasta dahil edildi. Hastalar hemodiyaliz grubu (n=29); periton diyalizi grubu (n=12), prediyaliz grubu (n=29) ve kontrol grubu (n=29) olarak gruplandırıldı. BULGULAR: Çalışmanın tüm katılımcılarından alınan biyopsi örneklerinin patolojik incelemesinde hemodiyaliz grubunda 20 hastada gastrit, iki hastada duodenit, 14 hastada H. Pylori pozitifl iği ve bir hastada malignite mevcuttu. On iki periton diyalizi hastasının 11’inde gastrit, üçünde duodenit ve yedisinde H. pylori pozitifl iği vardı. 29 prediyaliz dönemdeki hastanın 28’inde gastrit, ikisinde duodenit, 22’sinde H. pylori pozitifl iği vardı. Kontrol grubundaki 29 kişiden 27’sinde gastrit, yedisinde duodenit ve 19’unda H. pylori pozitifl iği bulundu. Gruplar arasında gastroskopik ve histopatolojik bulgular açısından fark yoktu. Proton pompa inhibitörü kullanımının bu bulgular üzerine etkisi yoktu. SONUÇ: Üremide mide mukoza fi zyolojisindeki değişikliklere rağmen, H. pylori enfeksiyon oranı ile gastroskopik bulgular üremik ve nonüremik popülasyonda farklı değildir.

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