Düşük Doz Radyasyon Alan Sıçanlarda Meydana Gelen Böbrek Hasarına Karşı Prunus armeniaca L (Kayısı)’nın Koruyucu Etkileri

Protective Effects of Prunus armeniaca L (Apricot) on Low Dose Radiation-Induced Kidney Damage in Rats

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Abstract (2. Language): 
OBJECTIVE: This experimental study was designed to evaluate radiation-induced kidney damage and the protective effect of apricot against it using histological parameters. MATERIAL and METHODS: Rats were divided into 6 groups each containing 10 Sprague Dawley rats as follows: Regc: Rats on a regular diet (control diet) for 28 weeks; control group. Regx: Rats on a regular diet for 28 weeks, XRE on last day of eighth week. Aprc: Rats on an apricot diet for 28 weeks; control for no XRE. Aprx: Rats on an apricot diet for 28 weeks, XRE on last day of eighth week. Reg+Aprc: Rats on a regular diet for 8 weeks, followed by an apricot diet for the following 20 weeks; control. Reg + Aprx: Rats on a regular diet for 8 weeks, XRE on last day of eighth week, followed by an apricot diet for 20 weeks. RESUL TS: The kidneys of the control groups showed normal kidney histology, whereas Regx group showed major histopathological changes, such as glomerular collapse, hemorrhage, interstitial fibrosis and inflammatory infiltrates. The Aprx and Reg+Aprx groups showed smaller amounts of degeneration. CONCLU SION: In conclusion, we suggest that agents with antioxidant properties such as apricot may have a positive effect in the treatment of renal diseases.
Abstract (Original Language): 
AMAÇ: Bu çalışmada amacımız, antioksidan etkiye sahip Prunus armeniaca L (kayısı)’nın böbrek dokusu üzerine radyoprotektif etkisinin histopatolojik yöntemlerle araştırılmasıdır. GEREÇ ve YÖNTEMLER: Çalışmamızda 10’ar adet Sprague Dawley cinsi sıçanlardan oluşan 6 grup kullanılmıştır. Kontrol (normal diyet) grubu: 28 hafta normal diyetle beslenen grup. Normal diyet+rad grubu: 20 hafta boyunca normal diyet alıp son 8 hafta normal diyet+ radyasyon alan grup. Kayısı diyeti alan grup: 28 hafta boyunca kayısı diyeti ile beslenen grup. Kayısı diyeti+Rad grubu: 20 hafta boyunca kayısı diyeti alıp son 8 hafta kayısı diyeti+radyasyon alan grup. Kayısı diyeti+normal diyet alan grup: 20 hafta boyunca kayısı diyeti alıp devam eden 8 hafta boyunca normal diyet alan grup. Rad+Kayısı diyeti alan grup: 20 hafta boyunca kayısı diyeti alıp devam eden 8 hafta boyunca normal diyet+ radyasyon alan grup. BUL GUL AR: Çalışmamızda, kontrol gruplarında normal histolojik yapı mevcutken, radyasyon grubunda glomerüler hasar, hemoraji, intertisyel fibrozis ve infiltrasyon gibi histopatolojik değişikliklere rastlanmıştır. Diğer taraftan, Kayısı diyeti+Rad grubu ve Rad+Kayısı diyeti alan gruplarda bu dejenerasyonların azaldığı tespit edilmiştir. SONUÇ: Sonuç olarak yaptığımız çalışmada radyasyona maruz kalındığında kayısı katkılı beslenmenin böbrek üzerine radyasyonun verdiği hasarı azalttığı tespit edilmiştir.



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