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Diyabetik Ratlarda Karaciğer, Böbrek ve Pankreas Hasarında Zofenoprilin Etkisi

The Effect of Zofenopril on Pancreas, Kidney and Liver of Diabetic Rats

Journal Name:

Publication Year:

DOI: 
10.5262/tndt.2014.1002.07
Abstract (2. Language): 
OBJEC TIVE: Oxidative stress is responsible for some important complications of diabetes mellitus. Zofenopril, which has an antioxidant effect, may decrease the oxidative stress of the diabetic microenvironment. The aim of our study was to evaluate the effect of zofenopril in the liver, pancreas and kidney of alloxan-induced diabetic rats. MATER IAL and METHODS: Rats were divided into five groups: control group (n=6), rats treated with zonenopril (50 mg/kg/day, orally four weeks; n=6), rats exposed to alloxane (120 mg/kg single dose intraperitoneal injection, n=6), rats administered alloxan+zofenopril (n=6) and rats administered insulin plus alloxan. RE SUL TS: After one month, we observed histological improvement in the kidneys but not in the pancreas and liver. CONCLU SION: In conclusion, zofenopril may be effective on the renal complications of diabetes mellitus.
Abstract (Original Language): 
AMAÇ: Oksidatif stres, sistemik bir hastalık olan diyabetin komplikasyonların önemli bir kısmından sorumludur. Antioksidan bir ajan olan zofenoprilin oksidatif hasara bağlı komplikasyonları azalttığı bilinmektedir. Çalışmamızın amacı alloksanla diyabeti indüklenen ratlarda karaciğer, böbrek ve pankreas hasarı üzerine zofenoprilin etkilerini ışık mikroskopu altında değerlendirmekti. GERE Ç ve YÖNTEMLER : Ratlar: kontrol grubu (n=6), zofenopril verilen grup (50 mg/kg/gün oral; n=6), alloksan verilen grup (120 mg/kg tek intraperitoneal enjeksiyon; n=6), alloksan+zofenopril verilen grup (50 mg/kg gun oral zofenopril; n=6) ve insülin+alloksan verilen grup olarak 5 gruba ayrıldı. Ratlara %0,9’luk NaCl solüsyonunda cözülmüş alloksanın taze hazırlanarak verilmesi yoluyla diyabet indüklendi. Zofenopril 4 hafta boyunca 50 mg/kg/gün dozda oral yolla verildi. BULGUL AR: Tedavi sonrası ışık mikroskopu ile yapılan değerlendirmede zofenoprilin böbrekte diyabet kaynaklı histopatolojik değişikliklerde düzelme sağladığı; ancak pankreas ve karaciğerde önemli bir histolojik değişme oluşturmadığını gözlendi. SONU Ç: Sonuç olarak, KBH’lı hastanın uygun bakım ve sevk yönetimi hayat kurtarıcıdır. KBH farkındalığı ve yönetim kalitesini arttırmak için yeni stratejiler geliştirilmelidir.
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