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Anti-Nükleer Antikor Negatif Lupus ile Birlikte Görülen ‘Full-House Nefropati’ Olgusu

A Case of Full-House Nephropathy with Anti-Nuclear Antibody Negative Lupus

Journal Name:

Publication Year:

DOI: 
10.5262/tndt.2014.1002.17

Keywords (Original Language):

Abstract (2. Language): 
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the development of antibodies against a variety of nuclear and cytoplasmic antigens. SLE renal involvement is referred to as ‘lupus nephritis’ and is generally associated with anti-nuclear antibody (ANA) positivity. ANA is negative in approximately 5% of patients diagnosed with SLE. Existence of full-house nephropathy is generally associated with lupus nephritis. Herein, we present a case of full-house nephropathy in a 48-year-old male patient with negative serology for SLE. The patient had signs of lupus such as oral aphthae, symmetrical polyarthritis, and diffuse proliferative glomerulonephritis.
Abstract (Original Language): 
Sistemik lupus eritematozus (SLE), çeşitli nükleer ve sitoplazmik antijenlere karşı antikor gelişimi ile karakterize otoimmün bir hastalıktır. SLE renal tutulumu ‘lupus nefriti’ olarak adlandırılır ve genellikle anti-nükleer antikor (ANA) pozitifliği ile ilişkilidir. SLE tanısı konmuş hastaların yaklaşık %5’inde ANA negatiftir. Renal biyopside ‘full-house nefropati’ varlığı genellikle lupus nefriti ile ilişkilidir. Bu yazıda, ‘full-house nefropatisi’ olan ve SLE serolojisi negatif olmakla birlikte oral aft, simetrik poliartrit ve diffüz proliferatif glomerülonefrit gibi lupus belirtileri olan 48 yaşındaki bir erkek olgu sunulmuştur.

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