A Case of Full-House Nephropathy with Anti-Nuclear
Antibody Negative Lupus
Journal Name:
- Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi
Keywords (Original Language):
Author Name | University of Author | Faculty of Author |
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Abstract (2. Language):
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the development of
antibodies against a variety of nuclear and cytoplasmic antigens. SLE renal involvement is referred to
as ‘lupus nephritis’ and is generally associated with anti-nuclear antibody (ANA) positivity. ANA is
negative in approximately 5% of patients diagnosed with SLE. Existence of full-house nephropathy
is generally associated with lupus nephritis. Herein, we present a case of full-house nephropathy in a
48-year-old male patient with negative serology for SLE. The patient had signs of lupus such as oral
aphthae, symmetrical polyarthritis, and diffuse proliferative glomerulonephritis.
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Abstract (Original Language):
Sistemik lupus eritematozus (SLE), çeşitli nükleer ve sitoplazmik antijenlere karşı antikor gelişimi ile
karakterize otoimmün bir hastalıktır. SLE renal tutulumu ‘lupus nefriti’ olarak adlandırılır ve genellikle
anti-nükleer antikor (ANA) pozitifliği ile ilişkilidir. SLE tanısı konmuş hastaların yaklaşık %5’inde
ANA negatiftir. Renal biyopside ‘full-house nefropati’ varlığı genellikle lupus nefriti ile ilişkilidir. Bu
yazıda, ‘full-house nefropatisi’ olan ve SLE serolojisi negatif olmakla birlikte oral aft, simetrik poliartrit
ve diffüz proliferatif glomerülonefrit gibi lupus belirtileri olan 48 yaşındaki bir erkek olgu sunulmuştur.
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